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Biomedical subjects

William L Oppenheim

Publications and source records attributed to William L Oppenheim.

4 recordsLinked to original sources

The internet 2006.

Each year Developmental Medicine and Child Neurology (DMCN) invites the President Elect of the American Academy for Cerebral Palsy and Developmental Medicine (AAPCDM) to compose a guest editorial. As we mark the 60th anniversary of the Academy, I welcome the opportunity to make a few observations on the emergence of the internet as a medium that, within the space of two decades, has had an increasing influence upon both medical research and its dissemination throughout the world. Although the Academy's founding fathers certainly recognized that communication was the key to future progress, it is unlikely that they could have imagined what was ahead in terms of instantaneous information exchange or how that capability would promote collaboration at great distances, speed up the decoding of the human genome, and empower patients with information that previously had largely been the province of academia. This September, portions of our annual meeting will be webcast from Boston to 10 locations in four different countries around the world. Individuals who cannot attend the meeting in person will have an opportunity to view the lectures, and then, in special sessions, to engage in real-time exchanges with many of the presenters. In addition, the AACPDM now presents a monthly 1-hour webcast for entitled members concentrating on timely subjects by world-renowned authorities.

Biomedical Research↗

Successful replantation of the leg in a pre-ambulatory infant.

The authors report the first successful replantation of a below-knee amputation in a 7-month-old infant prior to the development of a standing and walking gait. Seven years following surgery, the child demonstrates excellent ankle and knee range of motion, has regained plantar sensation, and is able to walk, run, and jump without needing a brace. Despite a leg-length discrepancy of 5.5 cm, it is likely that future overgrowth of the injured limb will improve this discrepancy. This child has excellent potential for a successful functional outcome, given the very young age at the time of replantation and the plasticity of the central nervous system.

Accidents, Traffic↗

Is treatment with growth hormone effective in children with cerebral palsy?

Children with cerebral palsy (CP) often have poor linear growth during childhood, resulting in a diminished final adult height. Here we report a female with CP and short stature but without growth hormone (GH) deficiency who exhibited increased growth during treatment with GH. We also report two other children with CP who were treated with GH: one female with a history of leukemia, and a male with Klinefelter syndrome. These two children were both found to be GH-deficient by insulin provocative GH testing and responded to treatment with increased growth rate. Growth improved to a greater extent in the two children with apparent GH deficiency. In summary, it is felt that GH therapy might be beneficial for children with CP and warrants further investigation.

Body Height↗

Outcome of slipped capital femoral epiphysis in renal osteodystrophy.

The cases of renal osteodystrophy-associated slipped capital femoral epiphysis in 11 consecutive patients were reviewed. Nine patients had bilateral involvement, totaling 20 hips. The mean age at presentation was 10.6 years. Slip location was physeal in 13 and metaphyseal in seven hips. All patients had prompt medical treatment of their bone disease, and nine patients underwent surgical stabilization. Fixation consisted of multiple custom-machined Steinmann pins that were smoothed distally but threaded proximally, allowing continued proximal femoral growth. The mean radiographic and clinical follow-up was 5.7 years and 9.1 years, respectively. Slips stabilized in 14 of 16 operated hips (88%), whereas one patient with inadequate renal disease control had slip progression requiring subsequent subtotal parathyroidectomy and repeat fixation. Combined medical management and surgery with custom-machined pins prevented slip progression while allowing continued physeal growth.

Adolescent↗