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Biomedical subjects

W Zimmermann

Publications and source records attributed to W Zimmermann.

At least 253 records · Page 14Linked to original sources
PubMed1978

[The effect of naloxone and levallorphane following fentanyl on the blood gases, EEG and psychodiagnostic tests (author's transl)].

After administration of fentanyl, 0.15 mg naloxone or levallorphan or placebo were given several times and in increased doses and at same intervals of time to six volunteers. The experiment has been done after the rules of a double blind study. Naloxone has shown its superiority to levallorphan. The study demonstrated a faster and better action of naloxone in the way of a return to initial conditions of respiratory frequency, blood gases, and EEG. The concentration and attention faculties after naloxone have become clearly better in contrary to the results after levallorphan. At the end of an anaesthetic procedure, the greatest care should be given to the patient. First of all effective antagonism of the respiratory depression should be obtained without concomitant sedative and psychomimetic effects. The use of antagonists with agonist properties to reverse respiratory depression due to a morphinomimetic drug is not justified and so naloxone should supplant levallorphan.

Adult↗
PubMed1977

[Investigations of carbromal metabolism (author's transl)].

Erythro-2-Brom-2-ethyl-3-hydroxybutyramide has been isolated from the urines of patients with Carbromal intoxications as well as from the urine of rat, mouse and dog treated with either Carbromal or with 2-Brom-2-ethyl-acetamide. The identification of the excreted and synthetized metabolite was carried out by means of IR, Mass and NMR spectroscopy. Along with the erythro-2-Brom-2-ethyl-3-hydroxybutyramide one other bromine containing compound was isolated after Carbromal application only, its mass spectrum and rel. RF values having the same characteristics as the synthetized erythro-2-Brom-2-ethyl-3-hydroxybutyrylcarbamide. However, the purification of this metabolite so far has not been successful.

Animals↗
PubMed1977

[Effect of pindolol (Visken) on the size and hemodynamics of the exerimental myocardial infarct in the pig].

In a comparative study the effect of pindolol (Visken, Sandoz) on experimental infarct size and left ventricular function in the pig has been investigated. Pindolol was given 30 min prior to the ligation of the left anterior descending coronary artery and on the following 5 days twice daily in a dosage of 0.05 mg/kg body weight. For morphometric assessment of infarct size the ventricular myocardium was cut into slices and stained with nitro-benztoluene. There is a significant reduction of infarct size (by one third) in the pindolol-treated group as compared to the controls. In addition, deterioration of left ventricular function is less marked in the pindolol-treated group.

Animals↗
PubMed1977

Function of the outer membrane of Escherichia coli as a permeability barrier to beta-lactam antibiotics.

On the basis of a simple theoretical model, the ease of penetration of beta-lactam antibiotics through the outer membrane of Escherichia coli was measured. The cell envelope was found to act as a diffusion barrier to both penicillins and cephalosporins. The validity of the model and the cooperative action of cell-bound beta-lactamase and outer membrane were further verified by comparing calculated and experimentally determined velocities of beta-lactam hydrolysis by intact cells and sonically treated cell suspensions. The results showed good correspondence at five different antibiotic concentrations. Similar conclusions could be drawn from a comparison of beta-lactam concentrations on both sides of the outer membrane, calculated from enzyme kinetic measurements and minimal inhibitory concentrations for both a beta-lactamase-producing E. coli and its enzyme-negative variant. in the case of benzylpenicillin and cephalothin, however, no correspondence was found. The joint action of several parameters determining the efficacy of penicillins and cephalosporins against beta-lactamase-producing E. coli is discussed.

Cell Wall↗
PubMed1977

Binding of thienamycin and clavulanic acid to the penicillin-binding proteins of Escherichia coli K-12.

Thienamycin and clavulanic acid are new beta-lactam derivatives with structures markedly different from those of penicillins or cephalosporins. Both derivatives had the same general mode of action as typical beta-lactam antibiotics since they bound to precisely the same proteins as [(14)C]benzylpenicillin. Thienamycin showed high affinity for penicillin-binding proteins 1, 2, 4, 5, and 6 and a lower affinity for protein 3. Protein 2 had the highest affinity for thienamycin, and concentrations from the minimal morphological change concentration (0.1 mug/ml) up to about 0.6 mug/ml resulted in the conversion of Escherichia coli KN126 into large osmotically stable round cells. Above a concentration of 0.6 mug/ml, rapid cell lysis occurred with the release of the cell contents as spheroplasts. Clavulanic acid showed good affinity for penicillin-binding protein 2, moderate affinity for proteins 1, 4, 5, and 6, and low affinity for protein 3. Protein 2 had the highest affinity for clavulanic acid, and concentrations from the minimal morphological change concentration (30 mug/ml) up to about 50 mug/ml produced a mixture of slightly elongated, swollen, bulging, and lemon-shaped cells. Above a concentration of 50 mug/ml, rapid lysis occurred with production of spheroplasts. The properties of thienamycin and clavulanic acid were compared with those of the penicillins, cephalosporins, and amidinopenicillanic acids.

Anti-Bacterial Agents↗
PubMed1976

CGP 9000: a new orally active, broad-spectrum cephalosporin.

CGP 9000, (7-[D-2-amino-2-(1,4-cyclohexadienyl)-acetamido]-3-methoxy-3-cephem-4-carboxylic acid), is a new broad-spectrum cephalosporin antibiotic. Its antibacterial activity in vitro (MIC) is similar, but its bactericidal efficacy superior to that of cephalexin and cephradine. Upon oral administration to mice infected with various bacteria, CGP 9000 is, in general, 2 to 7 times more effective than either cephalexin or cephradine.

Animals↗
PubMed1975

[The Mallory-Weiss syndrome (MWS)].

Mallory and Weiss (1929) described the syndrome which is characterized by hemorrhages from mucous membrane gaps of the cardia ner the esophagus. There are many causes responsible: sudden intraluminal pressure, obliteration of the mucous membrane, alcohol excess, voluminous meals, myocard infarction. In 3-5% hyperemesis is accompanied by Mallory-Weiss-Syndrome. For diagnosis endoscopy is the method of choice; if conservative therapy is without result, surgical measures are necessary. Lately endoscopic electrocoagulation gains more and more importance. 2 cases are reported.

Aged↗
PubMed1975

[Joint occurrence of spinal anomalies and colonic diverticula].

We investigated the radiographs of 125 patients with respect to variations of intestines (diverticula, polyps, carcinomas) and simultaneous anomalies in vertebral column (fissure of vertebral arches, asymmetric growth of vertebral arches, deterioration of ribs, fusing of vertebrae). There is a significant correlation between diverticula of colon and anomalies in vertebral column, whereas we found no correlation between other variations of intestines (polyps, carcinomas) and anomalies in vertebral columns. It is according to the theory of syndrome anomalies if there is an embryogenesis relation between anomalies of intestines and vertebral column.

Diverticulum, Colon↗