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Biomedical subjects

W Y Yang

Publications and source records attributed to W Y Yang.

At least 37 records · Page 2Linked to original sources
PubMed1993

[Effects of sex hormones on plasma lipoproteins in middle older age non-diabetes, diabetes and coronary heart disease].

We has observed the effects of sex hormones on plasma lipoproteins by analysing 165 patients of non-diabetes mellitus (NDM), diabetes mellitus (DM) and coronary heart disease (CHD) in the elder than 45 years. Of these subjects, NDM were 54, DM 47, CHD 48 and DM with CHD 16. The result statistically showed that is a significant difference in high density lipoprotein cholesterol (HDL-C) and Apolipoprotein A1 (Apo-A1) between male and female subjects in NDM group and general population (P = 0.0001, 0.003 and P = 0.009, 0.002 respectively), but this statistically significant difference could not be observed between male and female patients in groups of DM, CHD and DM with CHD. After adjusting multiple factors of age, body mass index (BMI), estradiol (E2), fasting plasma insulin (FINS), fasting blood glucose (FBS) by the stepwise procedure analysis, the levels of HDL-C and Apo-A1 have significantly negative association with the level of testosterone (T) (P = 0.0012 and 0.0040), however, have no association with E2. Total cholesterol (TC) and triglyceride (TG) have no association with T and E2. The result suggests that T should be an independent risk factor which reduces HDL-C level.

Age Factors↗
PubMed1993

Right gastroepiploic artery: an alternative arterial conduit for coronary artery bypass.

From September 1990 to February 1991, 15 cases of myocardial revascularization with the right gastroepiploic artery (RGEA) combined with arterial or venous grafts were performed at VGH-Taipei. All were males, ranging in age from 49 to 64 years (mean age 61.2 +/- 4.6 years). The mean number of distal anastmoses including vein grafts was 3.6 +/- 0.7 and the mean number of graft was 3.1 +/- 0.3 per patient. The mean aortic clamp time was 123.6 +/- 24.0 minutes and the mean cardiopulmonary bypass time was 176 +/- 35 minutes. There was one mortality (6.7%). The other 14 patients are alive without angina. Studied within 3 postoperative months, graft early patency was 100% (6/6) in GEA graft. GEA graft should be a third available arterial conduit for coronary artery bypass.

Aged↗
PubMed1992

[Repair of cerebrospinal rhinorrhea].

The present paper describes a new method for repairing the CSF rhinorrhea from the sella turcica using frontal muscle--galea aponeurotica--periosteum flap with blood vessel pedicle through cranial-nasal approach. This new method possesses the following advantages: short approach, clear field of vision, nose injury, few complications and less cosmetic influence. The flap, led into the sphenoid sinus Via the frontal sinus or the anterior cranial base and nasal roof, Survived and grew well due to its sufficient circulation and strong resistance to infection. For all the five cases described in this paper, among which three had accepted two or three repairs before, the CSF rhinorrhea ceased after only one procedure.

Adult↗
PubMed1992

[Antitumor activities of 4 derivatives of artemisic acid and artemisinin B in vitro].

The cytotoxicities of 2 derivatives of artemisinin B and 2 derivatives of artemisic acid (designated as Compound A, B, C, and D) were investigated, using trypan blue dye exclusion test and colony-forming units assay. At the concentration of 5 micrograms.ml-1, the inhibition rates of these 4 compounds against murine leukemia cell line P388 were > 85%. When tested against human hepatoma cell line SMMC-7721 at 25 micrograms.ml-1, the inhibition rates of Compound A, B, C, and D were found to be 92.3%, 96.9%, 84%, and 82.1%, respectively, and 27%, 8%, 37.8%, 1.7% against normal human embryonic lung cell line WI-38, respectively. These 4 compounds all showed an inhibition rate of 100% against human gastric cancer cell line SGC-7901 at 50 micrograms.ml-1.

Animals↗
PubMed1992

A new autoperfusion technique for aortic reconstruction of suprarenal aortic aneurysm.

Visceral ischemia is a serious factor in the postoperative morbidity and mortality of suprarenal aortic reconstruction. We reported two patients of suprarenal aortic aneurysm involving visceral arteries, who received successful Dacron graft replacement by using Pruitt-Inahara balloon catheters as an autoperfusion for preservation of the visceral organs. No visceral organ ischemia occurred postoperatively except in patient 2 who had preoperative chronic renal failure and persistent renal failure after the operation. The renal function recovered gradually during the follow-up period. Both patients are doing well at the present time. The new autoperfusion technique can directly deliver normothermic blood from the arterial cannula at proximal aorta to the individual visceral arteries by using the balloon perfusion catheters. It is simple, safe, easily instituted and the used products are readily obtainable. It allows the surgeon to provide an effective protection of visceral organs for the suprarenal aortic reconstruction.

Aged↗
PubMed1992

Pseudoaneurysm of the profundus femoris artery resulting from chronic injury of internal fixation screw.

We present an unusual case of pseudoaneurysm of profundus femoris artery which formed after injury from internal fixation screw for intertrochanteric fracture 8 years before. The main clinical manifestation was progressively enlarged pulsating mass and mild intermittent claudication. We resected the pseudoaneurysm after ligating the vessel proximal and distal to the pseudoaneurysm and cut off the excessive tip of the screw. After operation, the recovery was uneventful and no problem of the limb viability was noted.

Aged↗
PubMed1992

Cytotoxic activity of trewiasine in 4 human cancer cell lines and 5 murine tumors.

Trewiasine (TWS) is a mytansinoid compound. It possessed a significant cytotoxic activity against various human cancer cell lines in vitro. U937 cells, which were more sensitive to the TWS, required TWS 1 microgram.ml-1 to inhibit cell growth over 90% (P less than 0.01). TWS also showed activities against murine tumors in vivo, such as the ascitic tumors S180, hepatoma, U14, and solid tumor Lewis lung carcinoma. Depression of leukocytes was not seen when mice were given ip TWS 10 or 50 micrograms.kg-1.d-1 x 7 d. TWS 0.1-1 micrograms.ml-1 caused no sister chromatid exchange induction in Chinese hamster cell line V79.

Animals↗
PubMed1991

[Delayed gastric emptying in diabetes mellitus].

Function of gastric motility was studied in thirty one diabetes mellitus patients by testing gastric emptying time (GET). The test was performed by giving patients food labelled with 99mTc. The results showed that GET in patients with diabetes mellitus was significantly delayed as compared with that in the controls (P less than 0.001). 15 among the 31 diabetic patients had delayed GET, accounting for 48.4%. There was no difference in age, duration of the disease, treatment regimen and microvascular complications between patients with delayed GET and those with normal GET. The only difference was the obviously increased incidence of autonomic nerve dysfunction in the former group of patients (P less than 0.05). We concluded that the incidence of delayed gastric emptying time was higher in diabetic patients with autonomic neuropathy.

Adult↗
PubMed1988

Experimental tissue molding for soft-tissue reconstruction: a preliminary report.

Molding of pig omentum to create external structures, such as the ear or penis, was performed using silicone rubber molds. The omentum was mobilized on its gastroepiploic pedicle and brought out through a fascial defect. The molds containing the omentum were placed beneath the skin and panniculus carnosus for 4 weeks. Split-thickness skin grafts were placed on both surfaces of the mold, and a series of synthetic materials was placed within the omentum to provide structural support. When an appropriate amount of tissue had been placed within the device, omentum took on the contour of the mold. Excessive pressure associated with swelling resulted in necrosis, while an inadequate amount of tissue gave poor contour. Omentum molded without any support material rapidly lost its contour once removed from the mold. Omentum molded in combination with a synthetic material maintained its shape up to 1 month after mold removal in a limited number of animals. This model was designed to create structures with the fine detail of a prosthesis using autologous tissue. This "prosthesis" made from living tissue could then be transferred secondarily to its recipient area by microvascular technique.

Animals↗