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Biomedical subjects

W Y Hu

Publications and source records attributed to W Y Hu.

47 records · Page 3Linked to original sources
PubMed1996

The role of angiography in the evaluation of vascular and neoplastic disease in the external carotid artery circulation.

Angiography has a defined role in the management of vascular or neurologic diseases with less emphasis on screening and diagnosis and greater emphasis on pretherapeutic evaluation and endovascular treatment. This is especially true in diseases in the external carotid circulation. Advances in catheter technology and super-selectivity have improved our understanding of the anatomy and hemodynamics in normal and pathologic states. The functional neurovascular anatomy of the external carotid artery and diseases in which angiography has a role are reviewed.

Angiography↗
PubMed1996

Effect of chronic captopril treatment on circulating and tissue renin-angiotensin system in SHR rats.

AIM: To study the effect of captopril treatment and its withdrawal on the circulating and tissue peptidyl-dipeptidase A, angiotensinogen (AGT), and angiotensin II (A II), in relation to left ventricular hypertrophy (LVH) and systolic blood pressure (SBP). METHODS: SHR male rats were given captopril 100 mg.kg-1.d-1 [SHRcap, number (n) = 43] orally in mixture with milk powder as vehicle from intrautero period of 16 wk of age. Rats were killed at 16 (n = 19) and 40 (n = 24) wk of age, respectively. Male, age-matched untreated SHR and WKY rats served as controls. SBP, left ventricular mass/body weight (LVM/BW) ratio, left ventricular (LV) myocardium and plasma A II concentration, aortic and serum peptidyl-dipeptidase A activity, AGT mRNA level in kidney and liver, renal renin mRNA level were determined. RESULTS: Captopril treatment decreased SBP and reduced LVM/BW at 16 and 40 wk of age, and persistently inhibited LV myocardium A II, aortic peptidyl-dipeptidase A activity, and AGT gene expression in kidney even after the treatment was removed. Nevertheless, no changes were found in plasma A II concentration, serum peptidyl-dipeptidase A activity, and AGT mRNA level in liver by captopril therapy. Renal renin mRNA level was low in SHR and WKY rats, but it was increased by captopril treatment. Tissue renin-angiotensin system (RAS) such as AGT mRNA in kidney, aortic peptidyl-dipeptidase A activity, and LV myocardium A II, rather than circulating RAS (AGT mRNA in liver, renin mRNA in kidney, serum peptidyl-dipeptidase A activity and plasma A II), were persistently inhibited by early captopril treatment, even after the withdrawal of the treatment. CONCLUSION: The long-term inhibition of tissue RAS is one of the mechanisms of the persistent hypotensive effect of captopril treatment.

Angiotensin II↗
PubMed1992

A toxicological and epidemiological study on reproductive functions of male workers exposed to lead.

The reproductive ability of 24 men exposed to lead was observed and the same number of no-exposed men were taken as controls. The influential factors, such as age, smoking and drinking were controlled. The finding shows higher prevalence of congenital epilepsy and heart disease in the filial generation of workers exposed to lead and high rate of teratospermia in the exposed workers. Meanwhile hypospermia, as well as decreased lactate dehydrogenase-x(LDH-x) and succinodehydrogenase (SDH) in sperm were found in exposed group.

Adult↗
PubMed1991

[Effect of bile salt in duodenum on gastric myoelectric activity and motility of mouse with a preliminary study of its neuromechanism].

Changes of gastric myoelectric fast wave, slow wave and gastric motility were studied after intraduodenal infusion of sodium taurocholate (ST) in an attempt to search the concerned neuromechanism. Frequency and total amplitude of the fast wave and slow wave of gastric myoelectric activity and of gastric contractile wave were recorded every five minutes before and after intraduodenal infusion of ST under the background action of various drugs. The frequency and amplitude were expressed in percentage change of the respective premedication value. After intraduodenal infusion of ST (n = 10) the frequency and the amplitude of fast wave and gastric contractile wave were suppressed. Blocking anesthesia of celiac plexus, reserpinization and intravenous infusion of carbachol could eliminate the inhibition induced by ST, which could be partly eliminated by intravenous infusion of propranolol but not affected by phentolamine at all. The results demonstrate that intraduodenal infusion of bile salt suppresses the fast wave of gastric myoelectric activity and gastric motility, most probably controlled by efferent sympathetic adrenergic fibres through beta-receptor.

Animals↗
PubMed1987

Interaction between flurazepam and ethanol.

The interaction of a representative benzodiazepine, flurazepam, and ethanol has been assessed in ICR albino mice. Tests done included loss of "rotarod" performance, light sedation, deep sedation, loss of righting reflex, anesthesia, and lethality. LD50 and ED50s were plotted as isobolograms (plots of equieffective dose combinations). Data for anaesthesia and lethality showed little or no interaction between the two drugs. In contrast, the four motor and behaviour tests showed synergism, especially with higher doses of ethanol (over 2 g/kg) for righting reflex, and (over 1.5 g/kg) for deep sedation. Synergism occurred over all doses for light sedation and rotarod performance. It is expected that concurrent use of benzodiazepines and ethanol can result in a significantly higher accident risk in humans, but little additional risk of death from simple overdose.

Anesthesia↗
PubMedDate not supplied

Turning points of recovery from cardiac surgery during the intensive care unit transition.

OBJECTIVE: To explore the turning points of recovery from cardiac surgery of patients during the intensive care unit recovery transition. DESIGN: A descriptive qualitative design. SETTING: Three hospitals in northern Taiwan, Republic of China. PATIENTS: A convenience sample consisting of 30 adult patients (15 men and 15 women) who had undergone cardiac surgery. Age range was 20 to 67 years (mean, 46.6 years). OUTCOME MEASURES: The component, context, type, and positive or negative impact of turning points on patients' health. INTERVENTION: Data were collected through semistructured interviews and then analyzed by using qualitative content analysis. RESULTS: Turning points, which included events, nursing actions, and time, were examined in terms of the preceding conditions and the positive or negative health outcomes. Participants in this study fell into four main groups with regard to turning point experiences during the intensive care unit transition: those having experiences of turning points with both positive and negative outcomes (57%); those having experiences of turning points with a positive outcome only (33%); those having no experience of a turning point with either a positive or negative outcome (7%); and those having experiences of turning points with a negative outcome only (3%). Four classes of turning point experiences identified from the data encompassed "precedingness," inclusiveness, comparativeness, and multiplicity. CONCLUSIONS: We delineated the components, context, types, and positive or negative impact of turning points on patients' health after cardiac surgery during the intensive care unit transition. We also drew information on the nature, definition, and conceptual frameworks from data analysis to describe this phenomenon.

Adaptation, Psychological↗
PubMedDate not supplied

Taiwanese patients' concerns and coping strategies: transition to cardiac surgery.

OBJECTIVE: To explore patients' concerns during the admission transition to cardiac surgery. DESIGN: A descriptive qualitative design. SETTING: Four hospitals in northern Taiwan, Republic of China. PATIENTS: A purposive sample consisting of 40 adult patients (20 men and 20 women) who planned to have cardiac surgery. Age range was 20 to 70 years (mean 50.1 years). OUTCOME MEASURES: The types, levels, components, coping strategies, context, and conceptual framework of patients' concerns. INTERVENTION: Data were collected through semistructured interviews, and then analyzed using qualitative content analysis. RESULTS: Ninety percent of subjects (N = 36) reported two types of concerns: certain (80%) and uncertain (10%). Their certain concerns reflected three levels of concerns: "Caring about" or "Thinking about" (52%); "Worrying about" or "Being afraid of" (43%); and "Experiencing a mortal fear of" (30%), ordered from the weakest to the strongest. The components of patients' concerns were the process of recovery; hospital experiences, including maintaining daily activities, pain at admission, and expectant discomforts and disabilities in the intensive care unit; death; unfinished responsibilities and life goals, significant persons, and places; financial needs; and poor quality of care. Strategies developed to manage their concerns included (1) The use of person-focused effort (both cognitive and psychomotor), (2) Seeking help from others, including family members, friends, other patients, and health professionals, and (3) Turning to metaphysical power. The context for the phenomenon of Taiwanese subjects' concerns concerning cardiac surgery during the admission transition were "Being a person," resuming normality, and empowerment of self. CONCLUSION: The types, levels, components, and coping strategies of patients' concerns during the admission transition to cardiac surgery were discovered and delineated. The background context and conceptual framework for the phenomenon also were developed from the data analysis to describe and depict this phenomenon.

Adaptation, Psychological↗