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Biomedical subjects

W Y Hoffman

Publications and source records attributed to W Y Hoffman.

25 records · Page 2Linked to original sources

Immediate flap coverage in the treatment of large surgical defects after tumor resection.

Fifty-one patients with large surgical defects after tumor resection (range of 100 to 1,050 centimeters squared, mean of 259 centimeters squared) were treated with immediate flap coverage. Indications for flaps were exposed vital structures, a wound bed unsuitable for skin grafting or planned postoperative radiation. Patients were divided into three groups based on tumor location--head and neck, trunk and perineum and groin and extremity. Sixty-eight flaps (11 free and 57 pedicled) were used and all wounds ultimately healed. Overall, extensive complications occurred in eight patients, lesser complications in 11 patients and initial flap loss in three patients. While complications delayed healing, all defects were ultimately successfully covered using flaps. Preferred flap choices for each anatomic area are presented. By providing immediate coverage of these massive defects, flaps allow wide tumor resection that improves palliation and chance for cure. Flaps tolerate postoperative radiation well and do not obscure recurrence if careful follow-up examination is given.

Adolescent↗

Reanimation of the paralyzed face.

The challenge of reconstruction in the paralyzed face is to provide symmetry both at rest and in active expression. Although functional considerations must take precedence, the patient with unilateral facial palsy faces social stigmata that are exceptionally difficult. The best reconstructions in late paralyses fall far short of natural facial expression. Conley, one of the pioneers in facial nerve rehabilitation, reflected the frustration of dealing with limited techniques: It has been assumed by many surgeons that involuntary emotional communication is through the facial nerve, but this has never been substantiated. Indeed, emotional expression may be beyond our concept of a mere physical tract. It certainly has never been totally restored by any surgical technique that attempts to rehabilitate the face. When injury to the facial nerve is established, early nerve grafting on the ipsilateral side is the best treatment. In acoustic neuroma and other intracranial operations, the only real opportunity for grafting or repair is at the time of the procedure. If the nature of the injury is uncertain, a period of 12 months is allowed to elapse before consideration of intervention, which should be started if there is no return of function at that point. Electromyography may be of assistance in assessing minimal early return; if any early return is noted, further waiting is indicated. If there is no return at 1 year, cranial nerve XII to VII crossover will preserve facial muscle tone and permit a more measured decision-making approach. Patients with multiple cranial nerves involved may be candidates for a partial hypoglossal transfer using a nerve graft, to attempt to preserve swallowing. In selected cases, cross-facial nerve grafting to the preserved facial muscles will give excellent results and obviate the need for local or distant muscle transfers. When treating established paralysis of long duration, cross-facial nerve grafting with microneurovascular muscle transfer is the best option for symmetrical movement of the face. Temporalis and masseter muscle transfers should be reserved for the patient with intercurrent medical disease or the patient who refuses additional operations or operative sites. Static slings and other related procedures should be considered adjunctive but not primary treatment in the vast majority of cases. Although there are limitations in each of the procedures described, close cooperation between the otolaryngologist, the neurosurgeon, and the plastic surgeon can provide many patients with satisfactory rehabilitation from facial paralysis.

Facial Muscles↗

Influence of radiotherapy on microvascular reconstruction in the head and neck region.

Over a 5-year period at the University of California San Francisco, 42 patients who required microvascular reconstruction for abnormalities in the head and neck area were identified. Twenty-four patients (Group I) underwent reconstruction for a variety of neoplastic and non-neoplastic conditions and did not receive radiotherapy. Eighteen patients (Group II) had undergone previous radiotherapy averaging 6,090 rads. The mean ages for Group I and II patients were 40.7 and 55.5 years, respectively. In Group I, 13 muscle, 7 fasciocutaneous, 4 osteocutaneous, and 2 jejunal transfers were performed. In Group II, 11 muscle, 5 fasciocutaneous, 3 osteocutaneous, and 2 jejunal transfers were performed. Flap survival at 3 months was 88% in Group I and 95% in Group II. Wound complication rates were similar in both groups (15% Group I, 19% Group II), as was donor site morbidity (15% Group I, 29% Group II). Operative times (10.9 hours Group I, 10.6 hours Group II) and median postoperative hospitalization (14 days Group I, 16 days Group II) were comparable as well. Four of the five patients in whom the flap procedures failed were subsequently treated by a second microvascular reconstruction. Previous irradiation of the recipient bed did not appear to affect the success of subsequent microvascular reconstruction or the difficulty of such reconstruction as judged by operative time.

Adult↗

Computerized tomographic analysis of orbital hypertelorism repair: spatial relationship of the globe and the bony orbit.

Computerized tomographic scans provide a new means of evaluating the spatial and geometric relationships between the movement of the bony orbit and its soft tissue contents (the globe and extraocular muscles) [1, 12]. Preoperative and postoperative computerized tomographic scans were analyzed in four patients to explore these relationships. Measurement of the changes in distance between the globes correlated most closely with the change in the distance between the lateral orbital walls; resection of medial (inter-orbital) bone provides space into which the globe is translocated. The medial rectus muscle may be bowed across the medial wall osteotomy line, creating a functional shortening of the muscle; this finding may explain the esotropia that is commonly seen after this procedure [2, 3]. These observations should have a direct impact on the understanding and planning of orbital hypertelorism correction.

Adult↗

Rigid internal fixation vs. traditional techniques for the treatment of mandible fractures.

Treatment results were compared between mandibular fractures repaired with vitallium miniplates versus intermaxillary fixation (IMF) and wire osteosynthesis in 79 patients treated over a 4-year period. The postoperative courses of 35 patients treated with 46 plates were compared to those of 44 individuals treated with traditional reduction techniques. The plated group contained nine complications (26%) versus ten (23%) in the non-plated group. This difference was not statistically significant, despite the presence of more severe fractures in the plated group. Major complications (nonunions, malocclusions) were noted in only three (8%) of the plated group; there were six complications (14%) in the non-plated group. We conclude that the plating of mandibular fractures incurs no greater overall risk of complications than traditional methods of fixation, and a lower risk of major complications, and that the advantages of plate fixation, including decreased time of intermaxillary fixation and cost effectiveness, make this the method of choice in complex mandibular fractures, even in a high-risk population.

Adult↗

Volumetric quantification of intracranial and ventricular volume following cranial vault remodeling: a preliminary report.

This preliminary study documents preoperative and postoperative changes in cerebral tissue as well as intracranial and ventricular volume in patients who underwent cranial vault remodeling for craniosynostosis. The documentation and calculations were provided from CT data according to a craniofacial protocol. Three-dimensional images were then obtained of the preoperative and postoperative skulls and cerebral tissues. From these data, comparisons of preoperative and postoperative volumes of the cerebral tissue and ventricles could be examined. In one case, a frontal bone advancement combined with anterior cranial vault remodeling was associated with an increase in intracranial volume of 110 cc (8 percent) and a ventricular volume increase of 112 percent. The reported technique should allow more complete evaluation of the preoperative pathology and documentation and prediction of the projected intracranial and ventricular volume changes.

Brain↗