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Biomedical subjects

W Wirth

Publications and source records attributed to W Wirth.

At least 37 records · Page 2Linked to original sources
PubMed1980

Plasma zinc and magnesium alterations in acute myocardial infarction.

In 31 patients suffering from acute myocardial infarction plasma zinc and magnesium concentrations were measured. In acute infarction plasma zinc concentrations were strikingly decreased and plasma magnesium concentration slightly decreased. A close correlation between fall in zinc concentrations and the rise of serum CPK in these patients could be observed. No correlations were found between infarct localisation and sex and alterations in zinc concentrations. In contrast, a close correlation between fall in zinc content and severity of infarction occurred. Thus, the observed alterations in plasma zinc probably can be used as a diagnostic and prognostic indicator. Furthermore it should be considered whether zinc substitution would be of therapeutical benefit in patients suffering from acute myocardial infarction.

Creatine Kinase↗
PubMed1980

[Controlled double blind study on the effectiveness and adverse effects of acemetacin and indomethacin in the treatment of psoriatic arthritis].

In a controlled double blind study the therapeutic efficacy and tolerability of [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetoxyl]-acetic acid (acemetacin, TV 1322, Rantudil¿) and indometacin were tested in 40 patients (15 male, 25 female) suffering from psoriatic arthritis in which, in a period of three weeks, the patients received 180 mg acemetacin or 150 mg indometacin daily in form of three equally divided doses. In comparison with the initial values the acemetacin group in all three parameters tested, i.e., "pain, "limitation of function", "other signs of inflammation", showed a significant trend of improvement, while in the indometacin group only pain and inflammation could be improved significantly. With regard to the therapeutic ratios no difference could be established statistically between both groups. In the indometacin group side effects were observed nearly 4 times more frequently than in the acemetacin group; this difference is statistically significant (p < 0.1%). During the therapy with indometacin two withdrawals were necessary (1 because of inefficiency and 1 because of gastric complaints). In the acemetacin group there were no withdrawals. In 55% of all cases the therapeutic efficacy of acemetacin was judged as "good", in contrast to only 30% of the cases in the indometacin group. Acemetacin with regard to efficacy and tolerability seems to be clearly superior to indometacin.

Adult↗
PubMed1979

[2 cases of multiple myeloma with osteosclerosis].

A report on two patients with osteoclerotic myeloma is presented (myeloma with osteoblastic lesions). In case one, metastatic bone tumor of unknown origin was wrongly diagnosed initially. Because of increasing neurological symptoms laminectomy was performed. Biopsy led to the correct diagnosis of multiple myeloma of IgA-type. Patient also had a very severe peripheral neuropathy. The second patient had pancytopenia and osteosclerotic lesions of the pelvis. Bone marrow aspiration revealed so-called "empty marrow". Based on these findings, myelofibrosis was wrongly diagnosed at another hospital. Bone marrow aspiration, paper- and immunoelectrophoresis subsequently produced the correct diagnosis of multiple myeloma of IgG-type. Multiple myeloma usually is characterized by osteolytic lesions of the bones. However, the literature contains some 50 cases with osteosclerotic multiple myeloma, three different forms of which are described. In a fairly large percentage osteosclerotic multiple myeloma is combined with periphereal polyneuropathy. It would appear that in IgE-myeloma the incidence of sclerotic lesions is higher. Osteosclerotic multiple myeloma is very rare. It should however be considered if the differential diagnosis of osteosclerotic bone lesions is established.

Aged↗
PubMed1977

Characterization of the collagen synthesized by cultured human smooth muscle cells from fetal and adult aorta.

Smooth muscle cells were grown from explants of the tunica media of fetal and adult human aorta. Collagen was isolated after incubation with [14C]glycine and was characterized by ion-exchange chromatography. All cells investigated synthesized two types of collagen: Type I (chain composition [alpha1(I)]2alpha2) and type III (chain composition [alpha1(III)]3). The collagen made by cells from adult donors contained approximately 70% type I and 30% type III collagen. This corresponds to the collagen composition in teh original tissue. No age-relate change in the type I/type III ratio was found with cells from donors between 9 and 67 years of age. On the other hand, the type III portion of the collagen made by fetal cells was markedly less (about 15-20% of total collagen).

Adult↗
PubMed1977

[Complications in bilateral large lung cysts (author's transl)].

Complications in bilateral, congenital or acquired large cystic lesions in the lungs are a diagnostic and therapeutic problem. Early diagnosis and treatment is emphasized. When surgical treatment is necessary, decisions about the surgical procedures should be made knowing the in situ condition. Cooperation in decision making between bronchologist and thoracic surgeon is required.

Cysts↗
PubMed1977

[The management of bronchial hemoptysis - case study (author's transl)].

Two case reports exemplify, that in patients with massive hemoptysis occuring in the bronchial system and owing to known or unknown causes, the emergency surgery must not to be delayed. In the case of minor relapsing hemoptysis, especially in old-age patients or borderline operability, the minimum surgical procedure is indicated after diagnosing and finding the localization of the hemorrhage.

Adult↗
PubMed1976

[Primary extranodal lymphogranulomatosis of the flexura dodenal-jejunalis].

A primary extranodal lymphogranuloma of Hodgkin was found in the small bowel (PS II AE) of a 34-year-old man. Two years after radical surgery followed by local telecobalt therapy, the patient is in good health. The symptomatology, therapy and prognosis of this rare form of Hodgkin's lymphogranuloma are briefly reviewed.

Adult↗