[Lumbosacral transitional vertebrae in the dog].
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Biomedical subjects
Publications and source records attributed to W Winkler.
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In the recent past symptoms of a reorganization of laboratory medicine became apparent. They were brought about by methodological progress in analytical biochemistry, chemistry and also by the rapidly increasing efficiency of automation in the clinical laboratory as well as in medical practice. A somewhat parallel change also comes into existence in cytology and also, within certain limits, the histology. Since the early seventies the German Government, in accord with these developments, has supported some projects purporting to design better, more reproducible and more simple procedures in clinical diagnosis. With regard to cytological detection of malignancy this meant the development of methods to render cytological diagnosis a more potent tool for the recognition of cancer at an earlier stage on pre-selected material and with a high degree of sensitivity. Requirements on the quality of these methods with regard to reliability and safety will be discussed together with those marginal conditions which are expected to have a bearing on decisions aiming at the introduction of those methods into cytological routine. Consideration of those problems will be based on qualification requirements on prescreening procedures in general and manual cytological prescreening in particular. Discussion will also be extended on procedural sources of error.
A short survey of the chemistry of beta-blockers provides a description of the synthesis of carteolol hydrochloride (5-(3-tert-butylamino-2-hydroxy-propoxy)-3,4-dihydro-2(1H)-quinolinone- hydrochloride), the new pharmaceutically active substance of Endak and Endak mite tablets, and outlines some of its properties.
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Homozygotes of the mouse mutant limb-deformity (ld) reveal a reduced fertility and a high mortality of newborns. Unilateral and bilateral aplasia of kidneys is very common. In unilateral aplasia the right side is affected most, with no sex preference. All extremities show aplasias and synostoses, with 22 malformation types in the forelimbs and 8 types in the hindlimbs. Primary and secondary fusions of limb elements are found.
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