Biomedical subjects

W Wierzchowski

Publications and source records attributed to W Wierzchowski.

18 recordsLinked to original sources

PubMed2001

Morphological and clinical characteristics of antrochoanal polyps: comparison with chronic inflammation-associated polyps of the maxillary sinus.

OBJECTIVES: to compare morphological and clinical features of antrochoanal polyps and chronic inflammation-associated polyps of the maxillary sinus. STUDY DESIGN: histological and scanning electron microscopic examination of ten antrochoanal polyps and ten chronic inflammation-associated polyps of the maxillary sinus; comparison of clinical data in both groups of patients. METHODS: following surgical removal, the polyps were halved, the halves being processed for routine light microscopy (formalin fixation, paraffin embedding, HE staining) and scanning electron microscopy (formaldehyde/glutaraldehyde fixation, critical point drying, gold coating), respectively. Clinical data were retrospectively reviewed, tabulated and compared. RESULTS: the antrochoanal polyps differed from chronic inflammation-associated polyps of the maxillary sinus only in a few minor features; slightly longer duration of the process, lower incidence of maxillary ostial obstruction, higher incidence of frequent headaches, persistent nasal obstruction, presence of cysts in the polyp stroma, thickened basement membrane, lower incidence of squamous cell metaplasia, and higher proportion of migratory cells in nasal smears. In two cases, allergy was diagnosed but it seemed not to influence the polyps, which did not show morphological features typical of allergy-associated (eosinophilic) polyps. CONCLUSIONS: In spite of minor differences, antrochoanal polyps can be regarded as chronic inflammation-associated polyps with cystic origin and peculiar localization.

Adolescent↗

PubMed2001

[Drug allergy among patients suffering from nasal polyps].

The study was performed in order to evaluate quantity and morphology of nasal polyps in patients with diagnosed drug allergy to aspirin, antibiotics, polocain, procain and other drugs. The study included 60 patients (27 females, 33 males aged between 18-69 years). Nasal polyp morphology was examined under electron microscope and light microscope. Morphological evaluation of epithelial and subepithelial structures was done under light microscope, taking not of inflammatory infiltration type, basal membrane, as well as degree of intestinal edema. Evaluation of epithelial cell type, their relative proportion, as well as area percentage covered by cilium, microvilli and squamous epithelium was done under electron microscope. Polyps in patients with idiosyncrasy to polish aspirin and sodium metamizole (12 patients) featured increased eosinophilic infiltration, thickened basal membrane, with elevated eosinophil percentage differential count. The epithelial percentage area was covered by squamous cells without villi. Polyps associated with idiosyncrasy to polish aspirin differed morphology compared to polyps originality from patients allergic to other medications. On the other hand polyps from patients allergic to other drugs, such as: penicillin, procainamide were morphologically (electron light microscope, light microscope) similar to those polyps caused by inflammatory factors.

Adult↗

PubMed2001

[Poorly differentiated carcinoma of the thyroid--immunohistochemical evaluation of p53 and p27 protein expression].

Thyroid carcinomas represent a broad spectrum of tumours with different biologic behaviours. The gap between the indolent course of well-differentiated papillary and follicular carcinomas and the very aggressive behaviour of anaplastic carcinomas is filled by variants of thyroid carcinoma with intermediate prognosis, designated in the literature as poorly differentiated (with insular, trabecular and solid patterns) and tall/columnar cell variant of papillary carcinoma. The study has been carried out in 103 patients who had thyroid cancer with various grade of differentiation. The diagnostic significance of p53 and p27 expression in tumor cells has been investigated by immunohistochemical analysis. Well differentiated carcinomas have exhibited the lowest p53 staining frequency, the expression has been higher in poorly differentiated carcinomas and 100% of anaplastic carcinomas have been positive p27 immunohistochemistry has been positive in 80% of investigated carcinomas (in 15% strong positive reaction). In the group of poorly differentiated tumours positive reaction has been observed in 75% cases (in 15% strong positive reaction). Our data suggest that expression of p53 and p27 seems to have limited routine diagnostic significance, but p53 positivity is a good marker of tumour progression.

Adenocarcinoma, Follicular↗

PubMed2000

Characterization of implanted semiconductors by means of white-beam and plane-wave synchrotron topography.

Al(x)Ga(1-x)As epitaxic layers, with x = 0.43 and GaAs single crystals implanted with various doses of high-energy Se and Si ions, and silicon single crystals implanted with high-energy light ions were studied by means of different X-ray diffraction methods employing either a strongly limited white beam or a highly collimated monochromatic beam. The methods provided complementary characterization of lattice parameter changes and lattice deformation in the implanted layers. The synchrotron rocking curves recorded with a small-diameter beam provided a very good separation of interference maxima and enabled determination of the strain profile. A characteristic difference in strain depth distributions between the implanted A(III)B(V) compounds and silicon was noticed. Ion implantation in A(III)B(V) compounds produced a relatively thick layer with an almost constant and distinctly increased lattice parameter in regions close to the surface, whereas, in the case of silicon, shot-through layers with almost unchanged lattice spacing were observed. Other important information obtained from the synchrotron micro-Laue pattern was that the interference fringes caused by crystal curvature or strain gradient are located in the plane of diffraction, while parts of the Laue spot corresponding to the deformed regions are usually displaced.

Journal Article↗

PubMed2000

Maxillary sinus polyps secondary to dental extraction.

Polyps of the maxillary sinus were obtained from six patients who had reported upper tooth extraction with oroantral perforation prior to the development of symptoms, from 11 patients with chronic sinusitis, and from 12 patients with allergy. Histopathological features, scanning electron microscopy of the polyp epithelium and clinical data were compared in those groups of patients. The post-traumatic polyps differed from those of other aetiologies by showing the presence of granulomas, less numerous inflammatory cells with very few eosinophils, nearly normal surface epithelium (smaller surface area occupied by nonciliated epithelium, absence of epithelial squamous cells, normal frequence of goblet cells), rapid appearance of symptoms, and shorter duration of the disease. It seems that the specific characteristics of the injury-induced polyps results from a different mechanism of their formation, involving primarily abnormal mucosal repair and to a lesser extent an inflammatory process.

Adolescent↗

PubMed2000

[A case of malignant parapharyngeal schwannoma in a 29-year old woman].

The schwannoma malignum of parapharyngeal space is a very uncommon tumor. The case of the malignant neurilemmoma located in parapharyngeal space in 29-year-old female, is presented in the paper. The tumor was removed through the cervical-parotid approach. The post-surgery, follow-up examinations and CT check-up did not reveal any traces of recurrence.

Adult↗

PubMed1995

[Malignant fibrohistiocytoma of the larynx].

A patient in age 68 years with malignant fibrohistiocytoma of the larynx was surgically treated in the department of Otolaryngology, Medical University in Cracow. Fibrohistiocytoma is very rare tumor of the larynx. The diagnosis was supported by immunohistochemical examination. In the course of treatment were observed local relapses and neck metastases.

Aged↗

PubMed1992

Colorectal polyps in autopsy material. Part I. Adenomatous polyps.

In prospective studies specimens of the large bowel were obtained from 733 autopsy cases. After fixing they were examined under illuminated magnifying lens and all polypous lesions were excised for histological analysis and classified according to Correa's criteria (8). Adenomatous polyps were found in 280 cases (38.2%) and their prevalence increased with age in both sexes. Adenomatous polyps, also multiple were found most frequently in the transverse colon, and then ascending colon, sigmoid, descending colon and rectum. The mean number of adenomatous polyps per positive specimen was 2.33 for men and 2.60 for women. In 6.8% their diameter was > or = 10 mm. The prevalence of polyps with severe degree of dysplasia (III degree) increased from proximal to distal segments of the colon in both sexes and their prevalence is significantly higher in the ascending colon in women. In the whole series there were 6 adenocarcinomas of 5-18 mm in size, all in women over 80 years of age. The results of the present study were compared with the data concerning other populations of the world. In the light of a repeatedly confirmed a generally accepted relationship between adenoma and adenocarcinoma of the large intestine the results of our study seem to underestimate the prevalence of colon adenocarcinoma in the population of Cracow and Cracow district.

Adenocarcinoma↗

PubMed1991

[Histopathologic evaluation of the reactivity of soft tissue to dental acrylate implants--in vivo examinations].

Wistar rats were implanted subcutaneously with samples of the home-made metacrylate material Akpol S and, for comparative purposes, with samples of the imported materials Trevalon and Superacryl. Throughout a period of 7 weeks, at 7-day intervals, sections of the tissues surrounding implants were collected from the animals and examined histopathologically. No differences in the character of the inflammatory reaction ensuing around the implants made from the three tested materials were observed. The dynamics of increase in the thickness of a pseudocapsule which developed at the edge of the inflammatory infiltration around the implants made from Akpol S and Trevalon was similar, whereas analogous values for the material Superacryl were higher. The conducted comparative in vivo studies permit us to evaluate positively the home-made metacrylate material Akpol S.

Animals↗

PubMed1982