Independence of the cyclic AMP-lowering activity of thromboxane A2 from the platelet release reaction.
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Adenosine Diphosphate↗
Biomedical subjects
W Wierenga
Publications and source records attributed to W Wierenga.
beta-D-Arabinofuran[1',2':4,5]oxazolo-1,3,5-triazine-5-N-methyl-4,6-dione and analogues, unusually specific immunosuppressive agents.
Sequential treatment of the protected beta-D-arabinofuran[1',2':4,5]-2-aminooxazoline (2) with methyl isocyanate and diimidazole carbonyl afforded the 2,2'-anhydro-beta-D-arabinofuranosyl nucleoside, 6. Deprotection and hydrolysis yielded the corresponding arabinoside. Although the anhydronucleoside exhibited in vitro antiviral activity against herpes simplex type 1, it exacerbated the infection in vivo. Further examination uncovered an in vitro inhibition of the induction of a cell-mediated immune response without cytotoxicity.
Animals↗
The rapid separation and isolation of mono- and oligonucleotides by high speed liquid chromatography: an ion exchange, reversed-phase system.
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Chromatography, Ion Exchange↗