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Biomedical subjects

W Wieling

Publications and source records attributed to W Wieling.

At least 109 records · Page 6Linked to original sources
PubMed1988

Continuous non-invasive blood pressure monitoring: reliability of Finapres device during the Valsalva manoeuvre.

Because of the inherent risks of intra-arterial blood pressure monitoring a new non-invasive device, Finapres, which measures blood pressure continuously in the finger, was evaluated in 14 hypertensive and one normotensive subject. Brachial intra-arterial and finger pressures were compared during a control period and a subsequent Valsalva manoeuvre. Visually, blood pressures measured by Finapres faithfully reproduced the intra-arterial recordings in all subjects. From each pressure signal beat to beat systolic, diastolic, and mean blood pressure values and their differences were obtained and the time course of the response and its characteristic features were analysed. During the control period the Finapres measurements were lower than intra-arterial systolic, mean, and diastolic pressures (mean(SD) 1(9.6), 9(6.8), and 4(6.1) mmHg respectively). During the response to the Valsalva manoeuvre the brachial-finger pressure differences showed limited deviation from those during the control period; median differences were at most 6 mmHg occurring late during the intrathoracic strain period and 7 mmHg during the post-release blood pressure overshoot. In general, the Finapres device reproduced intra-arterial patterns faithfully. This device appears to offer a reliable alternative to intra-arterial blood pressure monitoring.

Adult↗
PubMed1988

Inflating one's own cuff does not increase self-recorded blood pressure.

To determine whether the muscular activity required to inflate a blood pressure cuff for self-recording influences the blood pressure at the instant of the subsequent measurement, finger blood pressure was recorded continuously during cuff inflation. Ten normotensive and seven untreated hypertensive subjects used their dominant hands to inflate, in 5 s, an occluding cuff on the same arm up to 200 mmHg. Blood pressure in the middle finger of the other arm was measured continuously by the Finapres device. Korotkoff sounds were determined by a microphone in the arm cuff, and the speed of deflation was kept constant by the investigator at 2-3 mmHg/s. Systolic pressure rose at the onset of inflation, with an average peak of 13 +/- 6 (s.d.) and 12 +/- 8 mmHg above baseline in the normotensive and hypertensive subjects, respectively. Five seconds after the onset of deflation both systolic and diastolic pressures in both groups had returned to baseline levels. Thus, self-inflation of a blood pressure cuff allows a valid measurement of blood pressure provided the recommended guidelines are strictly followed.

Adult↗
PubMed1987

Accuracy of auscultatory blood pressure measurement with a long cuff.

Intra-arterial blood pressure was compared with simultaneous auscultatory measurements in 37 subjects with a wide range of blood pressures and arm circumferences; six cuffs of various lengths and widths were used. Nineteen subjects had an arm circumference of 34 cm or more (mean 40 cm) and the other 18 were considered to be non-obese and had a mean arm circumference of 30 cm. With each larger cuff, in terms of bladder surface area, auscultatory blood pressure decreased a few mm relative to intra-arterial pressure both for systolic and for diastolic measurements. Apart from diastolic pressure measured with the two 12 cm wide cuffs (12 X 23 cm, 12 X 30 cm) in the obese group all other auscultatory measurements differed less than 5% from intra-arterial pressure, albeit with considerable variability among the subjects. The differences in error among measurements with the four largest cuffs in the obese group (13 X 30 cm, 14 X 30 cm, 14 X 38 cm, and a conical cuff) were clinically irrelevant, and there was even less to choose among all six cuffs in the non-obese subjects. These results suggest that auscultatory blood pressure may be measured with acceptable accuracy with a single long bladdered cuff both in subjects with large arms and in subjects with normal sized arms.

Adult↗
PubMed1987

Circulatory response to postural change in healthy male subjects in relation to age.

The initial heart rate (HR) response evoked by standing up and 70 degrees head-up tilt from the supine resting position, as well as the changes in HR and blood pressure after 1-2 min in the upright position, was analysed in teenage boys (aged 10-15 years) and healthy old men (aged 60-90 years). Standing up induced a characteristic temporary HR increase that lasted 20 s and far exceeded the gradual initial HR rise induced by head-up tilt. The main effect of age on the initial HR transients was a definite diminution of the response. After 1-2 min standing and tilting, young subjects showed a pronounced increase in HR and diastolic pressure with little change in systolic pressure. In contrast, old subjects showed a lesser increase in HR and diastolic pressure and a decrease in systolic pressure. A fall in systolic pressure of greater than 20 mmHg after 1 min of active standing was, however, not observed. It is concluded that the circulatory adjustment to the stress of postural change differs markedly between young and elderly subjects. In healthy old subjects marked postural hypotension appears to be rare.

Adolescent↗
PubMed1986

Acute dysautonomia associated with Hodgkin's disease.

A patient is described with acute dysautonomia associated with Hodgkin's disease. Testing of cardiovascular reflex control showed that this patient had a rare manifestation of autonomic cardiovascular neuropathy, namely intact parasympathetic heart rate control in combination with a sympathetic postganglionic lesion affecting the control of the vascular tree.

Adult↗
PubMed1984

Effect of physical exercise on blood lipids and adipose tissue composition in young healthy men.

In a prospective, controlled study, the influence of strenuous physical exercise on plasma total cholesterol, HDL cholesterol, apolipoprotein A-I, total triglycerides and fatty acid composition of adipose tissue was studied during 7 months of training in 15 senior oarsmen and 21 controls matched for age, smoking and drinking habits. Dietary intake was monitored. At the start of the study there were no differences in lipid parameters and adipose tissue composition between oarsmen and controls. A significant decrease in total cholesterol and total triglycerides and an increase in HDL cholesterol and apolipoprotein A-I was noted in the oarsmen after only 2 weeks of training. Body weight remained stable but skin-fold thickness decreased. Food consumption increased considerably but diet composition remained unchanged. Nevertheless the fatty acid pattern of adipose tissue changed significantly, as a result of altered preferential endogenous fatty acid synthesis and/or fatty acid oxidation. Since lipid parameters and adipose tissue composition were equal in oarsmen and controls before the start of the training, it is concluded that the changes induced by exercise only last for the duration of the training period.

Adipose Tissue↗