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Biomedical subjects

W Wieland

Publications and source records attributed to W Wieland.

31 records · Page 2Linked to original sources

[Experimental studies on the regeneration capability and prognosis of hydronephrosis].

There are conflicting opinions regarding the ability of kidneys to return to normal functioning following removal of an obstruction. Opinions also differ on the precision of radioactive iodine for the measurement of functional ability in obstructed kidneys. We tried to assess the value of nuclear medical methods in comparison to the classical physiological clearance methods. Furthermore, we tried to answer the following questions: how long can an obstruction be present before total recovery becomes impossible and when is it no longer worthwhile to perform conservative surgery?

Animals↗

[Sonography of the efferent urinary tract. Suprapubic and intravesical methods].

The ability of sonographic methods to demonstrate the urinary passages and their abnormalities were studied systematically. The ureters can only be demonstrated if they are dilated. Sonography of the bladder can be used as a screening method for tumours, diverticula and stones. Intravesical sonography is useful for staging of bladder tumours. The value of these methods is discussed.

Adult↗

[Ureteral reimplantation using the psoas bladder-hitch. Experience based on 111 operations in 100 patients].

In a 12-year period we performed 111 ureteral reimplantations with vesico-psoas hitch in 100 patients. The indication was a stricture of the lower third of the ureter in 51 ureters, vesicoureteral reflux in 31 ureters, and intraoperative laceration of the ureter in 25 patients. A congenital megaureter was the indication for ureteral reimplantation with psoas hitch in 4 cases. The operative result was classified excellent or good in 72% of the cases, and only 16% had to be regarded as operative failures. Ureteral reimplantation with vesico-psoas hitch is a versatile procedure that suits a number of indications, it is invaluable for the replacement of the lower third of the ureter in difficult cases, and it leads to a good long-term result in a high percentage of patients.

Adolescent↗

[Urachal cyst].

Explore the source record for details and available documents.

Humans↗

[Results of functional scintigraphy using 131J-hippurate in preoperative diagnosis of patients with kidney tumors: influence on surgical treatment and predictive value for retentional serum levels].

156 patients with renal tumors were studied using 131J-hippurate to assess the validity of functional scintigraphy in preoperative diagnosis and to compare it with the serum levels of Creatinine and Urea before and after tumor nephrectomy. If the contralateral, non tumor bearing kidney had a clearance (RNCL) of more than 200 ml/min, no pathological elevation was found postoperatively. If the RNCL was between 150 and 200 ml/min, the postoperatively elevated serum levels of Creatinine and Urea normalized within 3 weeks after surgery. Elevation persisted for longer than 3 weeks if the RNCL was between 100 and 150 ml/min. In RNCL below 120 ml/min an elevation was found even 6 months after surgery. Only if the RNCL was less than 100 ml/min (2% of all cases), instead of tumornephrectomy, an organ-conserving surgery was performed. In these cases, the results of renal scintigraphy yielded additional information in deciding the type of non-radical surgery. Therefore, renal functional scintigraphy does not need to be performed in patients with renal tumors under the following conditions: 1. no elevation of Creatinine and Urea preoperatively and 2. normal morphological findings (sonography, IVP, angiography, CT) of the contralateral kidney.

Creatinine↗

[Cystic acne and clinocomptodactyly in Klinefelter's syndrome (46XY/47 XXY mosaic)].

Klinefelter's syndrome was found in a 18 year old patient, suffering for four years from nodulocystic acne. Serum gonadotropins were within normal range, while histology of the testes revealed beginning tubular hyalinization. The case report shows that young patients with Klinefelter's syndrome may present symptoms that seem to exclude this syndrome. Furthermore, our patient exhibited klinokamptodaktylia of hands and feet, a congenital anomaly occurring very rarely in Klinefelter's syndrome.

Acne Vulgaris↗

The lymphogram in abdominal tuberculosis.

Lymphograms of 11 patients with histologically proven abdominal tuberculosis have been assessed in an attempt to define a typical pattern of appearance in retroperitoneal lymph glands. Glandular enlargement, poor glandular filling and lymphovascular obstruction were present. A gradient of abnormality with more marked adenopathy in the upper para-aortic chain extending to a lesser involvement below in the iliac chain was demonstrated in keeping with a retrograde spread of the tuberculosis process from the abdominal lymphatics cauded along the retroperitoneal chain. Lymphography may be valuable in cases where data from clinical observations and routine radiological studies is inconclusive in cases of vague abdominal disease.

Adolescent↗

Techniques for studies on growth characteristics of human prostatic cancer cells.

The methods described in this article seem to be useful for studies on the growth characteristics of malignant epithelial prostate cells which are still under the influence of healthy cells. Before establishing primary cultures, pieces of tissue were sectioned in such a way that they could be unfolded to obtain a large surface. These pieces were treated enzymatically and then incubated for at least 4-6 weeks. In this time, cells grew or migrated out of the tissue and spread over the surface of the culture flasks. The viable single cells harvested from these primary cultures were characterized flow cytometrically, fractionated by countercurrent centrifugal elutriation, or further incubated above agarose so that they formed three-dimensional spheroids. Cytometric determinations of cellular cytokeratin, vimentin, and DNA were performed before and after incubation. They suggested that the percentages of cytokeratin-positive (epithelial) cells, vimentin-positive cells (fibroblasts), and aneuploid cells remained at levels (in vitro) similar to those within the pieces of tissue used for the culturing experiments, respectively. Since our culture technique allows the propagation of human epithelial prostate cells in vitro as they would grow in vivo under the control of the surrounding tissue, the method should help to investigate which particular treatment of the cells influences the growth of the malignant cells, while they are still surrounded by other cells of the same prostatic organ.

Antigens, Neoplasm↗