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Biomedical subjects

W Weimar

Publications and source records attributed to W Weimar.

At least 325 records · Page 18Linked to original sources
PubMed1985

Infections after transplantation of a contaminated kidney.

In a retrospective study of 350 consecutive cadaver renal transplants, at least 83 (24%) of the donor kidneys were found to be contaminated. This was associated with three perinephric abscesses, one mycotic aneurysm, one pseudomonas sepsis, and four superficial wound infections. As a result, three patients lost their grafts, and one patient died from septic complications. The one year graft survival of the remainder of the recipients of contaminated grafts did not differ from that of the whole series. It is concluded that contamination of donor kidneys is a frequent event, but serious complications are relatively rare.

Bacterial Infections↗
PubMed1984

Recombinant leucocyte interferon A induces steroid-resistant acute vascular rejection episodes in renal transplant recipients.

In an attempt to determine the safety, tolerance, and prophylactic antiviral activity of high doses of recombinant DNA leucocyte interferon A a double-blind parallel-group study was started in 16 renal transplant recipients. All 16 patients had early rejection episodes. In all 8 interferon-treated patients and 1 placebo-treated patient this rejection, which was of the acute vascular humoral type, was steroid resistant. 3 interferon-treated patients also had transient nephrotic syndrome.

Acute Disease↗
PubMed1982

Highly purified leucocyte interferons for renal transplant recipients.

The effect of alternate day administration of four human interferons alpha on temperature, leucocyte and thrombocyte counts was evaluated in renal transplant recipients. These preparations were strikingly different in nature and concentration of impurities. No differences were found in side effects suggesting that they are not due to contaminants but to an intrinsic property of interferon alpha molecules.

Blood Platelets↗
PubMed1981

In vivo immune stimulation by interferon during viral infection.

Treatment of Rhesus monkeys with human leukocyte interferon prevents the development of skin lesions after intradermal infection with vaccinia virus. The treatment does not prevent the development of immunity to vaccinia. Inactivated vaccinia virus, which is non-immunogenic in untreated monkeys, induced immunity under interferon treatment, indicating that interferon had an immune-stimulating effect.

Adjuvants, Immunologic↗