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Biomedical subjects

W Weidner

Publications and source records attributed to W Weidner.

At least 199 records · Page 11Linked to original sources
PubMed1990

[Initial therapy of acute unilateral epididymitis using ofloxacin. II. Andrological findings].

A total of 70 men suffering from uncomplicated acute unilateral epididymitis were enrolled in a prospective study. They were treated initially with 2 x 200 mg ofloxacin p.o. per day for 14 days, after which the spermatological examination was repeated for each. Ejaculate quality, i.e. density, motility, and morphology of spermatozoa, was determined on the last day of therapy, i.e. after 14 days, and again after 6 and 12 weeks. In most patients, initially decreased sperm counts increased significantly and global motility improved, while the numbers of abnormal spermatozoa decreased. Only in a few cases were azoospermia, kryptozoospermia, consistently reduced motility, and constant or even increasing numbers of deformed spermatozoa observed.

Acute Disease↗
PubMed1989

[Sexually transmitted diseases as causes of disorders of male fertility].

Infections with sexually transmitted germs may affect the male fertility in different ways. Possible consequences are impairment of the spermatogenesis, induction of auto-immune mechanisms, spermatodysfunction, and inflammatory occlusion of the ejaculatory duct. Only in high concentrations, bacteria (e.g. E. coli) may result in reducing the motility of spermatozoa. The germ counts observed under clinical conditions, however, do not come up with these high levels. The same is true for mycoplasmas. As a whole, sexually transmitted infections only play a minor role with regard to male infertility.

Humans↗
PubMed1989

Fentanyl citrate analgesia during labor.

Fentanyl citrate is a potent short-acting narcotic reported to cause less nausea and sedation than morphine or meperidine hydrochloride. The purpose of this prospective investigation was to determine whether a safe but adequate intrapartum dosing schedule is possible. A total of 137 women with uncomplicated term pregnancies were offered a standard intravenous dose (50 mcg or 100 mcg hourly as needed) of fentanyl citrate during active labor. Temporary analgesia and mild sedation were apparent in each case. The cumulative dose varied in accordance with maternal needs (mean, 140 +/- 42 micrograms; range, 50 mcg to 600 micrograms). Apart from a brief decrease in fetal heart rate variability that lasted 30 minutes, no worrisome pattern was apparent from exposure to fentanyl citrate. Pediatric examinations were performed without knowledge of analgesic therapy on infants exposed to fentanyl citrate and those not exposed to analgesics. No differences were found in frequencies of newborn depressed respirations, low Apgar scores, or neurologic and adaptive capabilities at two hours and 24 hours postnatally. With the use of the described dosing schedule, fentanyl citrate was helpful during labor and did not cause immediate or prolonged hazards to the mother and unborn infant.

Adaptation, Physiological↗
PubMed1989

Experimental chlamydial epididymitis.

Male Wistar rats were infected with the chlamydial agent of guinea pig inclusion conjunctivitis by inoculation of chlamydiae into the vas deferens. Epididymitis was observed in all infected animals clinically and histologically. Chlamydiae were detected in the epithelium of epididymal tubules by immunohistochemical staining (alkaline phosphatase anti-alkaline phosphatase technique). Inflammation progressed from the cauda to the corpus and caput epididymidis leading to fibrosis of the cauda epididymidis 28 days after infection. Animals responded to the infection with a rise of both serum IgM and IgG antibodies.

Animals↗
PubMed1989

Intracavernous self-injection of prostaglandin E1 in the therapy of erectile dysfunction.

The efficacy of intracavernous autoinjection therapy with prostaglandin E1 was investigated over a period of up to six months in 187 patients with long-term erectile dysfunction. All patients had to undergo an investigation program consisting of routine laboratory tests, directional doppler sonography of the penile arteries, measurements of the BCR-latencies, as well as intracuvernum drug testing with PGE1. Six months follow-up results are available so far in 115 patients. The mean injection dose was 13.5 mcg PGE1 at the beginning of therapy and 12.8 mcg PGE1 at the end of therapy. An average of 24 prostaglandin E1 injections per patient was given. In 16.6% of the 187 patients slight to moderate pain occurred at the injection site, not influencing sexual intercourse. No priapisms lasting more than six hours were observed. A significant improvement of the blood flow in the deep and dorsal penile arteries was shown by penile doppler sonography after 6 months treatment. The efficacy and tolerability of the therapy were designated as very good to good in 91% respectively in 98% of the patients. 94% of the patients would like to continue the therapy. The results indicate that PGE1 due to its erectile potency and great tolerability will occupy an important position in the therapy of the erectile dysfunction.

Adult↗
PubMed1989

[Leakage correction by resection of the deep dorsal penis vein. Assessment of results after 4 years of venous potency surgery].

Resection of the deep dorsal vein is accepted as a short-term working procedure to reestablish erection in patients suffering from venous leakage. After 4 years with a standardized diagnostic and surgical program for pathologic venous drainage, we are now able to describe the outcome of vein resection in 51 men, whom we have treated 1-4 years before follow-up examination. After a median follow-up of 20 months, long-lasting full erection can be reported in 28 men. Of the remaining 23 men, reestablished erectile function decreased within 1 year in 8, while the operation failed in 15. Whereas the site of pathologic venous drainage and preoperative maintenance flow rates do not influence surgical outcome, a moderate arterial cofactor has become obvious in a large proportion of the unsuccessfully treated cases. In 14 of these men, papaverine testing has now become positive, so that penile self-injection of the drug makes adequate sexual intercourse possible. All patients with a postoperative negative papaverine reaction again have all the signs of a persistent pathological venous drainage; only in 2 of these cases has an ectopic vein been successfully resected.

Adult↗
PubMed1988

Clinical efficacy and tolerance of fleroxacin in patients with urethritis caused by Chlamydia trachomatis.

In an open study, 22 patients with genito-urinary infection by Chlamydia trachomatis were treated with oral fleroxacin in varying dosage. Symptoms were relieved and cultures became negative in 19 patients, with three patients not assessable. Adverse reactions, affecting the central nervous system, the gastrointestinal tract and the skin (photosensitivity), were reported in seven patients.

Anti-Infective Agents↗
PubMed1988

Role of Chlamydia trachomatis and mycoplasmas in chronic prostatitis. A review.

Acute bacterial prostatitis caused by common urinary tract pathogens is an infrequent disease, and diagnostic difficulties are rarely encountered. On the other hand, chronic prostatitis is a common disease requiring rather elaborate diagnostic procedures. We applied the localization protocol of the four-specimen technique and combined quantitative determinations of microorganisms and quantitative cytologic analysis plus, in chlamydial infections, serologic investigations. Our studies provide good evidence that Ureaplasma urealyticum and Chlamydia trachomatis must be considered etiologic agents in many cases of chronic bacterial prostatitis. These unconventional microorganisms are assumed to infect the prostate by way of intracanalicular ascension from the urethra.

Chlamydia Infections↗
PubMed1988

Pharmacocavernosography in the evaluation of erectile failure.

A total of 148 patients with erectile dysfunction underwent evaluation with Doppler sonography, cavernosography and intracavernous injections of papaverine. Arterial insufficiency was found in 63 patients (42.5%). Cavernosography following intracorporeal injection of papaverine revealed abnormal venous drainage from the cavernous bodies in 25 patients (17%) which, in 3 cases, was associated with Peyronie's disease. Results of vascular investigations were compared with the erectile response to the application of papaverine. Vascular insufficiency was observed in 39 of 55 patients (70%) with a poor response to papaverine. No patient with a venous insufficiency showed a good response. Nevertheless a poor response to papaverine did not exclude psychogenic impotence.

Contrast Media↗
PubMed1988

[Dysuria].

Explore the source record for details and available documents.

Female↗
PubMed1988

[Urethro-adnexitis of the male and sexually transmissible pathogens. A report of experiences of the Giessen study group].

In recent years, the improvement in microbiological diagnostic methods has caused the spectrum of infectious agents causing male urethroadnexitis to expand considerably. In addition to the well-known urinogenic enterobacteriae and enterococci and the sexually transmitted gonococci and trichomonads, Chlamydia trachomatis and Ureaplasma urealyticum must now be considered particularly important etiologic agents that are sexually transmitted. Their cell biology and epidemiology, our diagnostic procedures, and the criteria of etiologic classification of male urethroadnexitis are described in detail. The recently developed quinolone derivates offer new and promising therapeutic perspectives.

Balanitis↗
PubMed1988

[Long-term experiences with autoinjection therapy of papaverine in erectile dysfunction].

Long-term experience with intracavernous self-injection of papaverine in 36 patients with erectile failure is reported. The average required dose of papaverine in 2037 documented injections was 31.5 mg. The rate of complications was low with a mean follow-up of 6.9 months. Prolonged erections occurred four times. Two patients reported the development of tolerance. In one man circumscribed induration of the tunica albuginea was observed, which disappeared spontaneously after change of the injection site. No infections of the corpora cavernosa, circulatory disturbances or signs of hepatotoxicity were observed.

Adult↗
PubMed1988

[Experimental and clinical results with the ileum pouch as a continence-preserving replacement bladder].

Clinical use of the ileum-pouch for bladder reconstruction without stoma and direct anastomosis to the urethra is mandatorily based upon the three following conditions: sufficient capacity, low pressure values and protection of reflux in the neobladder. In an experimental study, we constructed a U-pouch with anastomosis to the urethra and implantation of both ureters into a cranial ileum horn. Already six weeks postoperatively an optimal capacity and real low pressure conditions of the neobladder have been achieved. Without any ileoileal invagination as antirefluxive procedure simple ureter-nippling provides a highly efficient protection against renal reflux in the so constructed neobladder. Our first clinical results do confirm our experimental data, demonstrating no reflux and almost total continence.

Animals↗
PubMed1987

Treatment of chronic bacterial prostatitis with ciprofloxacin. Results of a one-year follow-up study.

In a one-year follow-up study, short-term therapy with ciprofloxacin proved to be beneficial in the treatment of chronic bacterial prostatitis, particularly in cases of Escherichia coli prostatitis. Ciprofloxacin therapy of E. coli prostatitis was a complete success in five of 12 patients, a probable success in two, and in one patient the outcome cannot be judged. Ciprofloxacin treatment failed in three men, and therapy was discontinued in one patient because of side effects. Enterobacter aerogenes prostatitis was cured. Ciprofloxacin treatment was insufficient in three patients with Streptococcus faecalis prostatitis and in one patient with Pseudomonas aeruginosa prostatitis.

Adult↗