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Biomedical subjects

W Wegmann

Publications and source records attributed to W Wegmann.

At least 73 records · Page 4Linked to original sources
PubMed1980

Identification of neoplastic Paneth cells in an adenocarcinoma of the stomach using lysozyme as a marker, and electron microscopy.

A large number of cells containing large eosinophilic granules in their supranuclear cytoplasm was observed in a well differentiated adenocarcinoma of the stomach and its metastases. These cells were identified as Paneth cells by electron microscopy and by their content of lysozyme. Lysozyme-immunoreactivity was well preserved after fixation of tumor tissue in liquid formaldehyde followed by postfixation in osmium tetroxide. Immunoreactivity at immunoelectron microscopy was confined to the large osmiophilic secretory granules. We conclude that morphologically and biochemically differentiated Paneth cells occasionally occur in neoplasms of the gastrointestinal tract.

Adenocarcinoma↗
PubMed1979

[Rectosigmoidovesical fistula].

The symptomatology of vesico-colonic fistulae is presented and their differential diagnosis discussed. Management should be tailored to the individual case. Whenever possible, we perform a radical primary operation. An additional by-pass colostomy is indicated if it is felt that the integrity of the anastomosis is jeopardised.

Colon, Sigmoid↗
PubMed1978

[Histopathology of oral precanceroses].

The nomenclature used by gynaecopathologists for precancerosis of the cervix mucosa can be used equally for the oral mucosa. Cancer usually does not develop suddenly from a normal epithelium, but through an epithelial dysplasia into a non invasive, intraepithelial carcinoma. This process of cancerization probably lasts several years. Leukoplakia must not be generally regarded as precancerosis. The criterion is the degree of epithelial dysplasia and not the accompanying acanthosis, dyskeratosis, hyper- or parakeratosis. Light and medium severe epithelial dysplasia are regarded as facultative, severe epithelial dysplasia and carcinoma in situ as true precancerosis. The cytological examination should be used more frequently as a screening method.

Gingival Hyperplasia↗
PubMed1978

Prolonged survival after renal transplantation in primary hyperoxaluria of childhood.

Cadaver renal transplantation was performed in a 14-year-old girl with primary hyperoxaluria. Acute tubular necrosis was present initially, and a moderate rejection crisis occurred at 6 weeks. Renal biopsy performed at 4 months showed considerable deposition of calcium oxalate. Urinary excretion of oxalate varied between 315-371 mg/24 hr per 1.73 m2 (normal less than 50 mg). Despite these unfavourable factors, renal function has remained stable for the last 2 1/2 years; the serum creatinine is 1.5 mg/100 ml at 3 years. This is the longest surviving graft reported so far in documented primary hyperoxaluria. Graft failures in previous reports could in part be explained by additional complicating factors. It is concluded that renal transplantation is not necessarily contraindicated in primary hyperoxaluria.

Adolescent↗
PubMed1976

[The so-called white Burkitt's lymphoma].

A case of histopathologically proven Burkitt's lymphoma is described with special reference to clinical, serological and immunological features. This case report is followed by a review of the literature on the problem of American and African Burkitt's lymphoma. We can state that there is good correspondence between the white and black Burkitt's lymphomas with regard to epidemiology, histopathology, therapy and some immunological aspects. The two groups differ from each other in age, primary tumor manifestation, involvement of the bone marrow at time of diagnosis and quantitatively in the positive EBNA-test. It is therefore suggested that black and white Burkitt's lymphoma are not different diseases but different patterns of one disease.

Adolescent↗
PubMed1976

[Perforation of the small intestine in systemic diseases].

Small intestine perforations caused by systemic disorders are, except with M. Crohn, extremely rare. Therefore we report two cases of "spontaneous" small intestine perforations: one with hypersensitivity angiitis and one with Moya-Moya-disease, the latter not yet described in the literature.

Adult↗
PubMed1975

[Proceedings: Familial hemolytic-uremic syndrome. Studies on pathogenesis in the survivors].

The findings are reported in 4 siblings in whom death was due to typical hemolytic-uremic syndrome. In one, successive treatment with heparin, dipyridamole and aspirin was unsuccessful. 125I-fibrinogen half-life was 2.1 days under aspirin and 1.9 days under combined aspirin/heparin therapy. The parents and 4 surviving sibs had normal renal function and normal platelet and fibrinogen survival. The mother and 3 sibs had an increased percentage of megathrombocytes. Two exhibited renal accumulation of 51Cr-platelet radioactivity which was suppressed by platelet inhibitors. In both, renal biopsy disclosed definite ultrastructural endothelial alterations. These changes are probably responsible for the local platelet sequestration and appear to be the primary defect in this family with hemolytic-uremic syndrome.

Adult↗