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Biomedical subjects

W Weber

Publications and source records attributed to W Weber.

At least 307 records · Page 17Linked to original sources
PubMed1988

[Micromanipulation of gametes and pre-implantation mammalian embryos--a review].

With the successful management of the in vitro fertilization and embryo transfer in humans and in several mammalians it became possible to introduce further methods of the cellbiology in the practice. One complex in this connection is hereby shown to be the micromanipulation on gametes and on preimplantative embryos. With this technique the way was opened for some procedures which are known as microfertilization, transplantation of the nucleus and gene transfer somatic gene therapy. With these experiments a broad field of possibilities would be opened although about these can be only speculated.

Embryo Transfer↗
PubMed1988

[Lymphoepithelial hyperplasia of the tonsil at the base of the tongue].

A case report is communicated on lymphoepithelial hyperplasia of the tonsil at the base of the tongue. This may be demonstrated during radiological double contrast examination of the oesophagus as a protrusion of the mucosa of the hypopharynx with smooth or nodular relief pattern. Differential diagnosis is necessary especially against malignant neoplasms.

Adult↗
PubMed1988

[Anesthesia for magnetic resonance tomography].

Monitoring of the vital signs and the possibility of respiratory support are necessary conditions for the application of magnetic resonance imaging to infants and geriatric patients as well as during intensive care therapy. Since April 1986, 73 patients have been scanned under general anesthesia with controlled artificial ventilation in the Grosshadern University Hospital. For the first time, the ventilator could be placed in the vicinity of the magnetic resonance imaging scanner. With this system, the anesthesiologist is able to inspect the patient, ventilator, and monitoring unit from one place in the examination room.

Adolescent↗
PubMed1987

[Predilection sites of infantile skull fractures following blunt force].

Previous investigations on calvarial fractures in infants have shown that the flexibility and displacement of the infant calvarial are not sufficient to avoid fractures as a result of fall. From a table height onto hard ground - and in special cases, fractures cannot be avoided even after falls onto softly cushioned ground. The skull fractures are located in paper-thin, transparent, single-layer bone areas without diploe. The results of previous literature were compared with investigations of the skulls of 82 infants (from neonates up to infants 14 months of age). Congenital fissures, cranioschisis, locally retarded ossification in the cranium and craniotabes are all weak points where fracture has a tendency to occur even if the impact is minor. These ossification defects are increased in the ossa parietalia, but can also be found in the os frontale or in the os occipitale. The location is not always the same but can be detected by locating the skull transparency using diaphanoscopy.

Female↗
PubMed1987

Familial and histological analyses of 138 breast cancer patients.

A histological analysis was conducted in 138 female breast cancer patients, and the results were classified in accordance with "Histological Typing of Breast Tumours" (WHO, Geneva 1981). Since about half of these tumors showed more than one histological type of carcinoma, a simplified classification system with four groups was adopted. When patients were categorized according to the number and degree of kinship of their relatives with breast cancer, no specific association with the histological types was found. Familial tumors also encompassed a wide spectrum of histopathologic diagnoses. This suggests the absence of a histological marker in familial breast cancer. Pedigrees of all the patients were then analyzed, special emphasis being placed on relatives suffering from the same and other malignancies. It was found that 13.8% of the probands had at least one first-degree relative with breast cancer and that, compared with the tumor spectra in the male and female population, there was a significantly higher number of esophageal carcinomas in the fathers, of stomach cancers in the uncles and grandfathers, of brain tumors in the mothers, and of sarcomas in the brothers. An accumulation of the same tumors, especially stomach cancer and tumors related to the SBLA syndrome, was observed in families of index patients with tubular or medullary breast cancer. The SBLA syndrome is a complex familial cancer syndrome characterized by a proclivity to Sarcomas, Breast cancers, brain tumors, Lung and laryngeal cancers, leukemia, and Adrenocortical carcinomas.

Adenocarcinoma↗
PubMed1987

An EORTC Gastrointestinal Group phase II evaluation of epirubicin combined with 5-fluorouracil in advanced adenocarcinoma of the pancreas.

The EORTC Gastrointestinal Group has conducted a phase II trial in 47 patients with locally advanced or metastatic adenocarcinoma of the pancreas with epirubicin 90 mg/m2 intravenously on day 1 in combination with 5-fluorouracil 500 mg/m2 in a 2 hr infusion day 1-4, every 4 weeks. Of 43 evaluable patients there were six early deaths due to tumour progression and one due to a cerebrovascular accident. There were six partial responses for a response rate of 14% including early deaths. The median survival for all patients was 4 months. It is concluded that the addition of 5-fluorouracil to epirubicin does not appear to enhance the therapeutic results of epirubicin alone.

Adenocarcinoma↗
PubMed1987

[In families of ovarian cancer patients, breast cancer in females and colorectal cancers in males are overrepresented].

A detailed tumour-related family history was obtained from 30 women with histologically verified epithelial ovarian carcinomas. 46% of the anamnestic tumour diagnoses were also verified by obtaining copies of histology reports. Breast cancer was overrepresented among the female relatives and colorectal cancer among the male relatives. This study demonstrates that persons at high cancer risk as well as tumour-prone families of interest for aetiological cancer research can be identified by the simple method of obtaining a family history.

Adult↗
PubMed1987

[Computed tomography of atelectasis. A comparative experimental study].

After breathing pure oxygen, total atelectasis of one lung was produced in ten dogs; its development and regression was followed by CT and by conventional radiology. 30 seconds after cessation of ventilation, it was possible to show a rise in CT density of the atelectatic lung from -764 +/- 32 HU to -739 +/- 49 HU. The average time from the cessation of ventilation to total atelectasis averaged 5.5 +/- 1.1 minutes. The earliest sign on conventional radiographs was often seen after 30 seconds and usually after 60 seconds and consisted of mediastinal displacement. Extensive atelectasis regressed in only one out of six animals within one hour after resuming ventilation. The experimental methods and results and the significance of the physiological findings in a clinical context are discussed.

Animals↗