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Biomedical subjects

W Wagner

Publications and source records attributed to W Wagner.

393 records · Page 22Linked to original sources

[Acute necrotizing bone destruction of the maxillary and mandibular midline area in HIV infection cases].

An HIV positive patient with extensive destructions in the midline area of maxilla and mandible is presented. The diagnosis had to differentiate between rapidly progressing periodontitis, lethal midline granuloma, specific inflammation, and tumors. Course of the disease and histological workup led to the diagnosis of rapidly progressing periodontitis. The relationship between midline granuloma and immune deficiency should be noted.

Adult↗

Studies concerning the ergogenic value of protein supply and 1-carnitine in elite junior cyclists.

The effects of protein supply and 1-carnitine were recorded in a group of junior elite cyclists by a prospective double blind placebo controlled trial for six weeks (Refit milk powder containing about 90% proteins and 5% mineral salts-Ca, P, K, Na and 1-carnitine tablets). Seven top junior cyclists received orally 1 g protein/kg.d as supplement of food for six weeks and 2 g 1-carnitine, also orally, per day, 10 days before an important competition; other 7 cyclists received the same regimen as placebo. Significant and favourable changes were recorded in the treated group for the strength index, lean body mass, fat mass, TWP (total work-kgm, performed on cycloergometer 1', serum proteins, serum Hb, serum calcium) changes which did not appear in the control group. Serum cholesterol, creatinine, thymol test and serum GPT did not change significantly in either group. All athletes were under medical supervision, had a controlled training programme and food and received daily only vitamins and mineral salts. The treated group supported better the stress-induced efforts and obtained higher performances in the international competition which took place at the end of the experiment. Based on these data the authors recommend a supply of protein ratio up to 3.2 g/kg.d, six weeks before competition and 2 g 1-carnitine daily, also orally, 10 to 14 days before competition, including the day of competition, for cyclists, in order to improve the biological potential of the body.

Bicycling↗

Dental implants following radical oral cancer surgery and adjuvant radiotherapy.

Following radical oral cancer surgery and postoperative adjuvant radiotherapy with a total dose of 60 Gy, 71 IMZ and 150 Brånemark implants were placed in the mandibles and 28 Brånemark implants were placed in the maxillas of 60 patients between 1985 and 1995. Adjunctive hyperbaric oxygen therapy was not used. Osteoradionecrosis of the mandible occurred in two patients (3.4%), and necrosis of soft tissue in the floor of the mouth region occurred in three patients (5.2%). Twenty-one implants (18 in the mandible and 2 in the maxilla) were not osseointegrated when surgically exposed. In subsequent follow-up, 17 mandibular implants and 5 maxillary implants lost their osseointegration. The life table method indicated that 5-year actuarial implant success rates in the irradiated mandible were 77.5% for the IMZ system and 83.6% for the Brånemark system. These differences were not statistically significant. Retrospective analysis indicated that the success of implants in the irradiated mandible is determined after an interval of 18 to 24 months. For a small number of Brånemark implants in the irradiated maxilla, an actuarial success rate of 85.5% was found.

Adult↗

Hard and soft tissue reactions to ITI screw implants: 3-year longitudinal results of a prospective study.

Between November 1988 and July 1992, a total of 320 ITI screw implants were consecutively placed in 109 patients. The patients were observed in a prospective longitudinal study focusing on implant success and clinical proof. Radiologic and clinical parameters were established at specific time intervals to examine hard and soft tissue reactions. Clinical parameters and the measured bone resorption were analyzed for possible correlation. Seventy-five percent (n = 82) of patients were edentulous, and 16% (n = 17) had distal extensions or extended edentulous spaces. Nine percent (n = 10) of the implants were for single-tooth replacement. During the follow-up period, a total of 10 patients with 29 implants dropped out, and 6 implants were lost as a result of failed osseointegration. The cumulative implant survival rate was 98.1%, and the cumulative implant success rate, using strict criteria for success, was 97.1% after 3 years. The mean bone loss between implant placement and prosthetic restoration was 0.8 mm. For the period between prosthetic treatment and the 3-year examination, a mean annual bone resorption of approximately 0.1 mm was observed. The periodontal parameters indicated a healthy soft tissue response during the time of observation. The statistical correlation analysis showed a definite relationship between the crevicular fluid volume and bone resorption. The results of this 3-year study indicate that ITI screw implants, with their nonsubmerged healing characteristic, can serve as a reliable foundation for implant-supported restorations.

Adolescent↗