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Biomedical subjects

W V Lumb

Publications and source records attributed to W V Lumb.

At least 37 records · Page 2Linked to original sources
PubMed1978

Evaluation of polytetrafluoroethylene-graphite-coated total hip prostheses in goats.

This study was designed to determine if a porous polytetrafluoroethylene-graphite coating could furnish long-term stabilization of total hip prostheses. Prostheses were surgically implanted in 12 mature goats, which were observed postoperatively for as long as 1 year. Effective stabilization occurred in only 4 animals. Poor results in the other animals were attributed to lack of stabilization of the prostheses following initial implantation, which allowed movement at the interface between bone and polytetrafluoroethylene-graphite.

Animals↗
PubMed1978

Plating of canine scapular fractures.

The purpose in this study was to determine whether there was a significance difference between conservative management and plating of scapular body fractures. Bilateral scapular body fractures were created in 10 dogs. The left scapula in each dog was treated by open reduction and plating of the scapular spine. The right scapula was not treated. Plating enhanced healing and early return of function, but there was no significant difference in the long-term results.

Animals↗
PubMed1977

Inverse effect of chronically elevated blood flow on atherogenesis in miniature swine.

The effect of chronically elevated blood flow on the development of atherosclerosis in miniature swine was studied. Fistulas connecting the right external iliac artery and vein were surgically created in four swine, while three were not fistulated. Pulsed Doppler velocity detection cuffs placed around the abdominal aorta and both iliac arteries of all pigs permitted chronic measurements of blood velocity, blood velocity distributions, and blood flow. All swine were fed an atherogenic diet consisting of 20% beef tallow, 3% cholesterol, and 5% cholic acid for 6 months. This diet elevated the serum cholesterol to values exceeding 500 mg/100 ml. Creation of the arteriovenous fistula (AVF) markedly elevated blood velocity and flow in the abdominal aorta and in the shunted iliac artery. In the shunted animals the aortic blood flow was 42.1 +/- 2.0 ml/sec compared with 17.3 +/- 1.4 ml/sec in the unshunted swine. The velocity distribution pattern across the vessel was also indicative of an elevated wall shear stress. After 6 months, the animals were killed and the arterial vessels examined macroscopically and microscopically for the presence of atherosclerotic lesions. In the shunted pigs, 17 +/- 15% of the lumenal surface was occupied by sudanophilic lesions, whereas 80 +/- 8% of the surface was covered by lesions in the unshunted (control) pigs. From these studies, it is apparent that mechanical factors related to blood flow rates can influence the development of atherosclerotic lesions in swine.

Animals↗
PubMed1977

Cardiovascular response to fentanyl-droperidol and atropine in the dog.

A combination of fentanyl-droperidol was administered intravenously alone or with atropine sulfate (2 doses--0.04 or 0.02 mg/kg of body weight) to determine if stable neuroleptanalgesia could be produced in the dog. Cardiovascular responses were recorded at 5, 15, and 30 minutes. Fentanyl-droperidol given alone caused a significant increase of peripheral resistance and mean arterial pressure at 5 minutes and then a decrease of these values over a postinjection period of 30 minutes. Left ventricular dP/dt increased significantly at postinjection minutes 15 and 30. In dogs given atropine concurrently with fentanyl-droperidol, there was significant increase in heart rate and decrease in stroke volume. Also, there were significant initial increases in diastolic and mean arterial blood pressures, ventricular contractility, and coronary blood flow. The dose of 0.02 mg of atropine/kg seemed optimal for intravenous administration with fentanyl-droperidol in the dog; when the atropine dose was 0.04 mg/kg, large inotropic and chronotropic effects were produced.

Animals↗
PubMed1976

Aggressive pharmacologic and surgical treatment of spinal cord injuries in dogs and cats.

Aggressive pharmacologic and surgical treatment of spinal cord injuries in 22 dogs and 3 cats resulted in a recovery rate of 44% of all 25 animals. Excluding 5 animals that were euthanatized at surgery because of visualized cord transection and 5 that died during surgery because of secondary lesions, the recovery rate was 73%. This is compared with a recovery rate of 39% (7/18) for animals treated with more conservative methods at the same institution during an earlier period. Of the 7 animals without spinal cord transection and treated within 4 hours of injury, all recovered, pointing to the merits of early surgical intervention.

Aminocaproates↗
PubMed1976

Surgical preparation of miniature swine for atherosclerosis research.

A 2-stage surgical procedure for chronic intestinal, vascular, and lymphatic sampling in miniature swine is described. Cannulas were placed in the jejunum and ileum, followed by a 2nd implantation of indwelling catheters in the portal and hepatic veins, caudal vena cava, abdominal aorta, and cisterna chyli. The techniques used proved that miniature swine can be surgically adapted to meet experimental requirements.

Animals↗
PubMed1975

Neurological and pathological effects of second lumbar spondylectomy and spinal column shortening in the dog.

The second lumbar vertebra was surgically removed from 10 dogs, and the shortened vertebral column was stabilized by internal fixation with two types of plastic plates. Shortening of the spinal column was usually not associated with detectable loss of function or neurological deficit. Histological lesions, however, included widely disseminated axonal degeneration, gliosis, and atrophy of spinal nerve roots in the surgical area. The spinal cord adapted to shortening of the vertebral column by becoming intrinsically shorter, rather than be being displaced within the spinal canal.

Adaptation, Physiological↗
PubMed1975

A vascular catheter-implanting device.

A catheter-implanting device (CID) was developed to aid in the placement of vascular catheters in blood vessels located deep in the body cavities, with minimal vascular damage or blood loss.

Animals↗