Search PubMed⌕ Search

Biomedical subjects

W Urban

Publications and source records attributed to W Urban.

30 records · Page 2Linked to original sources
PubMed1988

[Not Available].

Explore the source record for details and available documents.

Czechoslovakia↗
PubMed1977

Prevention of 2-acetylaminofluorene-induced extrahepatic short-term effects by 3-methylcholanthrene.

It is well known that simultaneous application of polycyclic carcinogenic hydrocarbons, especially 3-methylcholanthrene (MC) inhibits or prevents tumorigenesis induced by carcinogenic aromatic amines or azo dyes. Short-term tests showed a mitogenic effect upon adrenal cortex 48 hours following a single dose of 2-acetylaminofluorene (AAF) among other carcinogenic substances. 6 mg/kg body weight given simultaneously prevent the proliferative response of the adrenals by AAF (60 mg/kg b.w.) in male Sprague-Dawley rats. These different effects can be assumed to depend on the production of carcinogenic derivatives or their non-production. Therefore, the positive adrenal reaction by other substances tested is probably also provoked by carcinogenic compounds. The lack of responsiveness by MC may reflect a fundamental change of AAF metabolism. The mode of action is unknown. Possible explanations are discussed.

2-Acetylaminofluorene↗