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Biomedical subjects

W Tulzer

Publications and source records attributed to W Tulzer.

42 records · Page 3Linked to original sources
PubMedDate not supplied

Massive digitoxin intoxication treated with digoxin-specific antibodies in a child.

A 20-month-old girl with massive digitoxin intoxication (initial digitoxin serum level: 629 ng/ml) was successfully treated with digoxin-specific antibody fragments (Fab). She presented with moderate signs of digitalis toxicity (somnolence, bradycardia, first-degree AV block) and improved rapidly during fractional Fab administration. Free serum-digitoxin disappeared after 6 vials of Fab (480 mg), but was measurable again on days 6 and 7. This case demonstrated that digoxin-specific antibodies, despite a 30-100 times lesser affinity for digitoxin, are effective in massive digitoxin intoxications. A rebound phenomenon may occur several days later and should be taken into consideration.

Digitoxin↗
PubMedDate not supplied

[Nephropathy gonadal dysgenesis--or incomplete Drash syndrome?].

This is a report about a phenotypical normal girl with nephropathy and gonadal dysgenesis. At the age of 2 years 8 months she presented with steroid resistant nephrotic syndrome. Focal segmental glomerulosclerosis was found by biopsy. Because of delayed puberty karyotyping was performed, which revealed 46 XY. Thirteen years after onset of proteinuria she reached end stage renal failure. Gonadal dysgenesis and nephropathy are often indistinguishable from incomplete Drash syndrome. Children with early nephropathy of unknown origin or gonadal dysgenesis should be observed for development of Wilms tumor. When chronic nephropathies are present in girls, karyotyping should be considered.

Adolescent↗
PubMedDate not supplied

[Luteoma of the mother as a possible cause of external female pseudohermaphroditism].

Maternal virilization association with the birth of a virilized female infant has been reported in gravidas with luteoma. We describe a similar case with ambiguous genitalia (type Prader III). The only pathological finding was an elevated postpartum maternal serum testosterone (4.11 ng/ml). Excluding all differential diagnosis we conclude, that the only possibility for the virilization of the newborn female was a luteoma.

Androgens↗