Biomedical subjects
Publications and source records attributed to W Tuganowski.
Trans-gap application of noradrenaline or acetylcholine evoked pronounced inotropic but no chronotropic effects in spontaneously active rabbit auricle preparations. These results suggest the existence of intracellular receptors, both adrenergic and cholinergic, which were involved in the control of auricular contraction.
Propranolol introduced by a cut-end method into atrial trabeculae evoked negative inotropic response without any significant changes in basic electrical parameters. This effect was resistant to noradrenaline but not to dibutyryl cAMP. These results suggest that existence of intracellular beta adrenoreceptors involved in the control of the contraction.
Adenosine abolished action potentials and slowed down depolarization in the sinus node cells, and depressed the slow component in the working fibers. Noradrenaline and dibutryl cAMP did not counteract the effects of adenosine in the working myocardium whereas in the pacemaker, dibutryl cAMP alone evoked low frequency spontaneous activity.