Adult Still's disease manifesting as erythema nodosum.
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Adult↗
Biomedical subjects
W Torinuki
Publications and source records attributed to W Torinuki.
Liver involvement in Tsutsugamushi disease.
Tsutsugamushi disease, one of the rickettsiosis, is known to be occasionally accompanied by elevation of hepatic enzyme levels. However, there are only a few reports on histopathological findings of the liver. We presented a case of Tsutsugamushi disease with liver involvement. A 51-year-old man suffered from eruptions and a high fever with a mild transaminasemia. He was diagnosed as Tsutsugamushi disease by detection of IgM class antibody against Rickettsia tsutsugamushi. Laparoscopic examination showed a dark-brown liver with diffuse whitish markings. Microscopic findings were consistent with the features of non-specific reactive hepatitis: sinusoidal small lymphocyte infiltrations, mild disarray of hepatocytes and aggregation of T lymphocytes and macrophages in the lobule.
Humans↗
Contact dermatitis to biperiden and photocontact dermatitis to phenothiazines in a pharmacist.
A case of contact dermatitis to biperiden, an anti-Parkinson agent, and photocontact dermatitis to phenothiazines in a pharmacist was reported. The patient developed eczematous lesions on exposed area after she had worked at a psychiatric hospital for 6 months. She showed positive patch test reaction to biperiden. In addition, she reacted positively to photopatch testing with ultraviolet A and phenothiazines such as chlorpromazine and perphenazine. To our knowledge, contact dermatitis to biperiden has not been previously reported in the English literature.
Biperiden↗
Acquired port-wine stain.
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Arteriosclerosis↗
Wegener's granulomatosis successfully treated with prednisolone and potassium iodide.
Wegener's granulomatosis has traditionally been treated with steroids and cyclophosphamide. We used potassium iodide in conjunction with prednisolone to treat a patient with a limited form of this disease who had gangrenous rhinitis and skin involvement including necrotic papules and ulcerations. After three months of this therapy, the mucosal and cutaneous lesions had almost completely disappeared.
Drug Therapy, Combination↗
Two cases of porphyria cutanea tarda associated with chronic hepatitis positive for the antibody against hepatitis C virus.
We report two cases of porphyria cutanea tarda (PCT) positive for the antibody against hepatitis C virus (anti-HCV). The serological and histological examinations revealed that they were persistently infected with HCV and were suffering from liver disease compatible with chronic viral hepatitis. It is suggested that one of the factors which contribute to liver damage of patients with PCT may be HCV infection. It now may be advisable to examine anti-HCV in PCT patients with liver disease.
Chronic Disease↗
Bullous pemphigoid masquerading as porphyria cutanea tarda in a patient on haemodialysis.
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Adult↗
Mucha-Habermann disease in a child: possible association with measles vaccination.
A 2.5-year-old boy presented with skin lesions consistent with Mucha-Habermann disease, which appeared about 5 days after an injection of freeze-dried live attenuated measles vaccine. He responded to both oral and topical corticosteroid therapy. To my knowledge, this represents the first such association of Mucha-Habermann disease with virus vaccination.
Child, Preschool↗
Two patients with solar urticaria manifesting pruritic erythema.
Two patients with solar urticaria are described. They complained of transient pruritic erythema, but not frank wheal, on sun-exposed areas. However, urticarial wheals were elicited by polychromatic radiation in the ultraviolet and visible light ranges; the action spectra for solar urticaria ranged from 400 to 550 nm in case 1 and from UVA to 550 nm in case 2. In patients manifesting only transient pruritic erythema on sun-exposed areas, phototests are essential for making a confident diagnosis of solar urticaria.
Adult↗
Photocontact dermatitis due to piroxicam: photopatch testing.
I report a case of photocontact dermatitis due to piroxicam gel, a nonsteroidal anti-inflammatory drug. A 62-year-old man developed pruritic eczematous lesions after applying the gel for 2 days. The patient reacted positively to photopatch testing with ultraviolet A and piroxicam (1% and 0.1% in petrolatum). In addition, the patient had positive patch tests to thimerosal, thiosalicylate, and in vitro-irradiated solution of piroxicam plus human serum albumin, but the tests with the mercurial compounds were negative. These results support the close relationship between sensitivity to thiosalicylate component of thimerosal and photosensitivity to piroxicam, as indicated recently.
Cross Reactions↗
Phototests in Japanese patients with papulovesicular light eruption: positive provocation with UVA.
In six Japanese patients with papulovesicular light eruption (PVLE), photoprovocative tests were performed by irradiating UVA or UVB on the skin of the back on three consecutive days. One patient developed the typical lesion of PVLE at the test site with two consecutive daily irradiations of UVA. The remaining 5 patients had no abnormal phototest reactions. It was obvious that UVA plays an etiological role in at least some cases of PVLE.
Adult↗
Generalized erythema-multiforme-like eruption following allergic contact dermatitis.
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Adult↗
Ultraviolet-B phototest in patients with atopic dermatitis.
To evaluate the possibility of ultraviolet (UV) rays as an aggravating factor of atopic dermatitis (AD), UV-B phototest was performed in patients with AD. Resulting, minimal erythema doses for UV-B were all within normal range and AD lesions were not reproduced by irradiation. UV-B may not be an important factor for skin aggravation in patients with AD.
Adolescent↗
Increased mast cell numbers in the sclerotic skin of porphyria cutanea tarda.
We quantitated numbers of mast cells in the sclerotic skin noted on the dorsa of the hands of 10 patients with porphyria cutanea tarda (PCT), and compared them with those of diffuse scleroderma and healthy controls. Mast cell counts in sclerodermoid skin of PCT patients were significantly greater than those in involved skin of 9 patients with diffuse scleroderma in its late stage and also greater than those in normal skin of 8 controls. When mast cell density was analyzed according to the depth of the dermis, an 84% increase was noted in the uppermost layer (0-0.2 mm in depth) and a 150% increase in the second uppermost layer (0.2-0.4 mm in depth) in the patients with PCT when compared with those in the corresponding sites of the controls. These results suggest a possible role of mast cells in the pathogenesis of sclerodermoid skin of PCT.
Adult↗
Plasma concentrations of complement-modulating proteins (C1 inhibitor, C4 binding protein, factor H and factor I) in inflammatory dermatoses with special reference to psoriasis.
By using single radial immunodiffusion, plasma levels of four complement-modulating proteins, i.e. C1 inhibitor (C1INH), C4-binding protein (C4bp), factor H and factor I were measured in 42 psoriatic patients and in 60 patients with other inflammatory skin diseases in comparison with 27 normal controls. In psoriatic patients and those with related pustular dermatoses, the levels of C4bp, factor H and factor I were significantly increased. They correlated well with both extent of skin changes and disease activity. In contrast, in nonpsoriatic inflammatory dermatoses only factor H values were significantly increased in toxic erythema and factor I in atopic dermatitis. These results offer additional support for the hypothesis that the complement system is involved in psoriasis and related sterile pustular dermatoses.
Adult↗
Incidence of skin cancer in Japanese psoriatic patients treated with either methoxsalen phototherapy, Goeckerman regimen, or both therapies. A 10-year follow-up study.
To determine the long-term cutaneous side effects of methoxsalen phototherapy (PUVA) and Goeckerman regimen, a total of 151 Japanese psoriatic patients treated with PUVA, Goeckerman regimen, or both therapies in our department from 1976 to 1986 were evaluated for skin cancers. Sixty-seven patients had been treated with PUVA, 43 with Goeckerman regimen, and 41 with both therapies. One patient alone (62-year-old man) developed squamous cell carcinoma on the leg with cumulative ultraviolet A (UVA) dose of only 51 joules/cm2, he had a history of treatment with superficial x-ray therapy to this area 30 years prior to PUVA. The cancer was detected after 1.4 years of PUVA treatment. However, other patients at follow-up, even those who had received a cumulative dose of UVA of more than 1000 joules/cm2, had no skin cancer after more than 2 years. This report in Japanese patients confirms that only previous exposure to other risk factors such as ionizing radiation appears to be a most important factor for skin cancer formation in PUVA-treated Japanese patients.
Adolescent↗
Stimulation of human melanocytes by vitamin D3 possibly mediates skin pigmentation after sun exposure.
We found an increased amount of immunoreactive tyrosinase in human melanocytes after 6-d culturing with vitamin D3 (cholecalciferol). Most of these melanocytes became more dendritic and swollen in a fashion similar to that noted in the skin after ultraviolet irradiation. However, 7-dehydrocholesterol (pro-vitamin D3) or 1 alpha,25-dihydroxy-vitamin D3 (activated vitamin D3) were found to have little effect on the same system. Because vitamin D3 is known to be photochemically converted from pro-vitamin D3 in the skin by ultraviolet irradiation, the mechanism of human skin pigmentation after ultraviolet irradiation, thus far unknown, may be at least partly explained by this stimulating effect of vitamin D3 on melanocytes.
Cholecalciferol↗
Photosensitive psoriasis provoked by a suberythematous dose of ultraviolet-B light.
An unusual case of 'photosensitive psoriasis' is reported. This patient had experienced an exacerbation after sea-bathing, and psoriatic eruptions were observed on the sun-exposed areas of the body. Phototesting with ultraviolet-B (UV-B) revealed his minimal erythema dose to be within normal limits. Three to four weeks after phototesting, however, he developed a psoriatic macule on the area exposed to the suberythematous dose of UV-B. The histologic features of the skin lesion provoked by UV-B irradiation were similar to those of naturally occurring lesions on areas covered by clothes. Moreover, failure to reproduce skin lesions following tape-stripping ruled out a proneness of this patient to develop the Köbner phenomenon nonspecifically.
Adult↗