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Biomedical subjects

W Tischer

Publications and source records attributed to W Tischer.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Urodynamic investigations. Volume/flow and pressure/flow relationship in children (author's transl)].

Subject of the report are urodynamic investigations in 122 children with a normal urinary tract and in 168 children with disturbances of the subvesical outflow. The children were divided into four groups corresponding to age and sex. Measuring methods were uroflowmetry and cystometry. The latter was performed with small urethral plastic catheters 1,5 mm in diameter. In comparison with the investigations without catheter our measured values show a revoked or distinctly decreased dependence of the maximal urinary flow on the micturition volume. This behaviour can be explained by an approximately maximal widening of the subvesical outflow tract due to the obstructive effect of the catheter. The pressure/flow relations confirm this behaviour. They correspond to those of a rigid tube with individual constant diameter. This condition permits a good comparison between the measured values and an accurate separation between normal and pathologic cases. Normal ranges of the pressure/flow relations at the moment of maximal flow were calculated and presented by diagrams. Pathologic micturitions can be differentiated and classified by such diagrams. Among the various urodynamic methods the uroflowmetry has a good diagnostic value in boys. With the urethra resistance relation PQmax/Qmax2 a subvesical obstruction may be recognized in both sexes. A better assessment of the functional obstructive effect with regard to compensation and decompensation is only possible with the demonstrated pressure/flow diagrams.

Adolescent↗
PubMed1980

[Neurogenic urination disorders in childhood. II. Therapy].

In this paper a short survey of therapy methods is given which are necessary for the treatment of neurogenic disturbances of micturition. It is in detail reported on several electrotherapy methods. The own experiences with the transurethral electrostimulation and with the development of an electronic pacemaker for the urinary bladder are reported.

Child↗
PubMed1980

[Manometric reading of rectal pressure profiles (author's transl)].

A catheter with two side holes is inserted into the rectum and perfused by a rate of 3,1 ml/min. When drawn back (0,7 mm/sec) the recto-anal pressure is recorded. In this way normal readings of the pressure profile are established in different age groups of children and compared with reading recorded by the open-tip-method.

Adolescent↗
PubMed1980

[Fractures of the distal end of the humerus in children (author's transl)].

This study reports on follow-up controls of 53 children with fractures of the humerus near the elbow-joint. 31 children had supracondylar fractures, 11 condylar fractures and 11 other lesions of the lateral epicondylus. The examination was carried out with special attention to functional aspects. A new own method for measuring the flexion force of the elbow is described. Baumanns angle and the dia-epiphyseal angle were taken into consideration when examining the X ray pictures. We obtained the best results when treating supracondylar fractures by Baumann's extension method. All condylar fractures should be operated on. The follow-up results were also excellent in the operatively fixed fractures of the lateral epicondylus.

Biomechanical Phenomena↗
PubMed1979

Purification and some properties of a hitherto-unknown enzyme reducing the carbon-carbon double bond of alpha, beta-unsaturated carboxylate anions.

2-Enoate-reductase, a previously unknown soluble enzyme is present in Clostridium kluyveri and another Clostridium species growing on (E)-2-butenoate. From the latter the reductase was purified 88-fold with an overall yield up to 74%. The enzyme was pure as judged by polyacrylamide gel electrophoresis with and without sodium dodecyl sulphate as well as by isoelectric focusing. The purification of the enzyme was performed in the presence of (E)-2-methyl-2-butenoate as substrate to keep the enzyme in the oxidized state and under anaerobic conditions. The purification procedure included an ammonium sulphate precipitation, chromatography on DEAE-Sepharose CL-6B, hydroxylapatite and Sepharose CL-6B. The enzyme reduces different alpha,beta-unsaturated carboxylate anions such as (E)-2-butenoate, (E)-2-methyl-2-butenoate, (E)-cinnamate and probably many others in a NADH-dependent reaction to the saturated carboxylate anions. Fumarate, 3-phenyl-2-propinate, 2-enoyl-methyl and CoA esters proved not to be substrates for the purified reductase. NADPH does not act as an electron donor. The enzyme was shown to have a molecular weight of about 450,000 by gel chromatography. It consists of subunits with a molecular weight of 78,000. Per subunit about 1 FAD, 3.5--3.8 atoms of iron and 4.0 labile sulphur atoms have been found indicating a conjugated iron-sulphur flavo-protein. Copper could not be detected. The isoelectric point was 8.4. As shown by absorption spectroscopy the enzyme can be reduced by NADH and reoxidized with dichloroindophenol, hexacyanoferrate III, oxygen and substrates. Addition of 8 mol p-hydroxymercuribenzoate to 1 mol subunit completely destroyed the activity of the reductase. So far no physiological role of the enzyme is known.

Amino Acids↗
PubMed1979

[Urodynamic miction studies--physiological aspects].

In this work, definition and interpretation of different functional parameters, which were obtained through urodynamic investigations, are given. Normal patterns in child age are presented. They were the results of personal studies in patients with normal urinary tract. The pressure curve must be seen as an entity. The so-called after contraction is no detrusor contraction. But possibly it is the result of a determined lapse of contracting and relaxing occurrences in the different parts of the bladder and its outlet at the end of micturition.

Adolescent↗
PubMed1979

[Neurogenic disorders of bladder emptying in children].

Disturbed micturition of the neurogenic type is found in children suffering from spinal tumors and anomalies of the vertebral column. The most frequent cause is the so-called myelomeningocele. Myelodysplasia can occur in 1-2 out of every 1,000 new-born babies. Operative treatment is available today (closing the celes immediately after birth and drainage of the associated hydrocephalus) so that these children survive and their fate essentially depends on the early diagnosis and therapy of the neurogenic micturition disturbance. Urodynamic examinations and the determination of the urethra pressure profile are vital for diagnosis. Using the results four different groups can be established each requiring a specific therapy. Individual therapies must also be selected for each individual case. Apart from operative treatment, drugs and electrostimulation can be used on a large scale. The authors present their own experience and results with regard to diagnosis and therapy.

Child↗
PubMed1979

[Neurogenic bladder dysfunction in childhood. I. Diagnosis].

The diagnostic demands of the neurogenic disturbances of the voiding of the bladder in patients with myelodysplasia are summarized in tabulated form. It is reported in detail on own experiences of the authors with urodynamic measuring methods and with the electromyography of the striated musculature of the floor of the pelvis. At present the two methods are not yet used everywhere and they are a considerable enrichment of the diagnostics.

Electromyography↗