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Biomedical subjects

W Timmermann

Publications and source records attributed to W Timmermann.

84 records · Page 5Linked to original sources
PubMed1980

[Action of cyclosporin A and cytimun on the survival time of accessory heart transplants (author's transl)].

The new immunosuppressive substances Cyclosporin A (group A = 15 mg) and Cytimun = ASTA 5122 (group B = 15 mg, group C = 5 mg) were tested in rats that received accessory cervical heart transplants. A syngeneic (DA leads to DA) and a strongly allogeneic (PVG leads to DA) strain combination served as controls of operative and immunogenetic parameters. Whereas Cyclosporin A (group A) brought about a local transplant tolerance in 90% of cases, at a dosage of 15 mg/kg per day (group B), Cytimun led in 88% of cases to lethal intoxication of the recipients. At a dosage of 5 mg/kg per day (group C), 67% of the animals survived; however, they showed electrocardiographic evidence of possible temporary rejection crises between the 5th and the 13th day.

Animals↗
PubMedDate not supplied

Adjuvant therapy for gastric adenocarcinoma with the apoptosis-inducing human monoclonal antibody SC-1: first clinical and histopathological results.

In a first clinical trial with the apoptosis-inducing human antibody SC-1 eight patients with poorly differentiated stomach adenocarcinoma of diffuse-type received 20 or 30 mg of purified SC-1 antibody intravenously, followed 24 or 48 h later by gastrectomy and lymphadenectomy. In seven cases a significant induction of apoptotic activity was measured in primary tumors as compared with earlier biopsy material and in five patients a significant regression of tumor mass could be determined histopathologically. No toxic crossreactivity was observed with normal tissue or organs of patients.

Adenocarcinoma↗
PubMedDate not supplied

Progress in experimental intestinal transplantation in small animal models.

The unique immune response after small bowel transplantation (SBT) has been the subject of extensive research using small animal models in rats and mice. These animals are inexpensive, for most societies ethically acceptable and the existence of inbred strains allows for reproducibility and defined immunobiological conditions. The basic immunological reactions, such as graft-versus-host-reactions (GVHR), host-versus-graft-reactions (HVGR), a combination of both reactions, chronic rejection and tolerance have been described. Almost all immunosuppressive agents of proven or potential clinical relevance have been tested for their efficacy in small bowel transplantation. All techniques which are applied to intestinal transplantation in humans including multiorgan transplantation, can also be performed in rats. Intestinal transplantation in mice is methodically restricted to heterotopic transplantation. The mouse however, offers several advantages compared to the rat model. A large number of congenic and knockout strains is available as well as many analytical tools. In the future, intriguing new insights into the unique immunological mechanisms of allograft rejection will be discovered using murine models.

Animals↗