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Biomedical subjects

W Thompson

Publications and source records attributed to W Thompson.

At least 145 records · Page 8Linked to original sources
PubMed1978

A randomized controlled trial of selective planned delivery.

A prospective randomized controlled trial designed to investigate selective planned delivery is reported: 264 obstetrically normal women in the 38th week of pregnancy were admitted to this trial and 184 completed it. The infants of mothers in the planned delivery group had higher serum bilirubin levels on the fifth day post partum than control infants but no baby required treatment for hyperbilirubinaemia. Mothers in the planned delivery group required significantly greater amounts of pethidine while control mothers had a significantly higher incidence of meconium staining of the amniotic fluid. However, the infants in the two groups had similar Apgar scores at birth. There was one stillbirth in the control group; this was due to unrecognized fetal hypoxia during labour induced at 42 weeks for postmaturity.

Apgar Score↗
PubMed1978

Reinnervation of partially denervated rat soleus muscle.

The reinnervation of partially denervated rat soleus muscles by their interrupted, regenerating motor axons has been examined in adult white rats. If reinnervation occurred after the remaining, intact motor axons had sprouted to their full, maximal extent, then the regenerating axons formed synapses preferentially with denervated muscle fibers and not with fibers innervated by sprouts. The sprouted motor units retained their size as if no reinnervation had occurred. On the other hand, if reinnervation occurred early during the sprouting process, the sprouting motor units were never able to attain their maximal size. Further, some muscle fibers became innervated by both sprouted and regenerating axons. These "hyperinnervated" fibers lost their dual innervation within a few weeks. The sprouted axons seemed to be the nerve fibers preferentially eliminated from these hyperinnervated fibers, since during the loss of hyperinnervation the sprouted motor units decreased in size while the motor units formed by the regenerating axons did not change in size. It is proposed that the occurrence of hyperinnervation is influenced by the amount of time sprouting axons have to consolidate their synapses with muscle fibers. Further, it is proposed that on muscle fibers which can become hyperinnervated, the sprouted motor neurons are at a disadvantage in the competition for maintenance because of their larger unit sizes.

Animals↗
PubMed1978

Subcellular distribution of lysophosphatidylinositol and lysophosphatidylcholine acyltransferases in rat brain.

Lysophosphatidylinositol acyltransferase utilizing arachidonoyl CoA and lysophosphatidylcholine acyltransferase utilizing linoleoyl CoA were measured in subcellular fractions of rat brain. In general, the distribution of activities paralleled that of NADPH--cytochrome c reductase. It is concluded that the endoplasmic reticulum is the major site of these acyltransferase activities in rat brain.

1-Acylglycerophosphocholine O-Acyltransferase↗
PubMed1977

Fetal hiccups.

Explore the source record for details and available documents.

Female↗
PubMed1977

Evaluation of measurement of maternal plasma alpha-fetoprotein levels as a screening test for fetal neural tube defects.

Maternal plasma alpha-fetoprotein (AFP) levels were estimated on 1844 consecutive patients at the time of their first hospital antenatal visits. There were 28 pregnancies with an 'abnormal' outcome: 19 patients had twins, 3 had an anencephalic fetus, and 6 a fetus with a spina bifida (4 of these had an open neural tube defect). Evaluation of maternal plasma AFP levels as a screening test for neural tube defects at 15 to 19 weeks gestation indicated a sensitivity of 50% taking the 'cut-off' point as the 95th centile of the plasma AFP levels in pregnancy with a normal outcome.

Anencephaly↗
PubMed1977

Clinical significance of scintillation camera electronics capable of high processing rates.

The use of larger scintillation detectors with high-efficiency converging collimators has greatly increased the photon input rate to the crystals of scintillation cameras in many clinical studies. To process these high-count-rate data accurately, modifications have been made by some manufacturers in the electronics of scintillation cameras. Cameras with new electronic design were compared with earlier models with respect to count rate processing capability and the effect of high input rate on spatial resolution, pulse-pair pileup, image size, and instability of the amplification of energy pulses. The improvements with the new electronic design result in shorter imaging times, better preservation of resolution, increased statistical reliability, and reduced distortion of dynamic tracer curves used for quantitative analysis.

Coronary Circulation↗
PubMed1976

Cytidine diphosphate diglyceride of bovine brain. Positional distribution of fatty acids and analysis of major molecular species.

A method is described for the isolation of CDP-diglyceride from bovine brain. Yields of the product ranged from 9.2-15.5 mumol per kilogram of tissue, which corresponds to about 1% of the level of phosphatidic acid. Mild alkaline hydrolysis of the product gave three water-soluble phosphate esters which had the same electrophoretic mobilities as CMP, CDP-glycerol and glycerol 3-phosphate. The liponucleotide was quantitatively hydrolysed by CDP-diglyceride hydrolase from Escherichia coli to phosphatidic acid and CMP. No dCMP was recovered in enzymatic or alkaline hydrolysates and it is concluded there can be little or no dCDP-diglyceride in bovine brain. Brain CDP-diglyceride was similar to phosphatidylinositol in that in both lipids stearate was the major saturated fatty acid and arachidonate the most abundant unsaturated fatty acid. This differed significantly from the fatty acid patterns of other metabolically related phospholipids, phosphatidic acid and cardiolipin. Brain CDP-diglyceride was hydrolysed with phospholipase C from Clostridium welchii with the liberation of the diglyceride moiety in high yield. Treatment of the diglyceride with pancreatic lipase showed CDP-diglyceride with the asymmetric distribution of fatty acids characteristic of most mammalian phospholipids, saturated fatty acids being found mostly at position 1 and polyunsaturated fatty acids at position 2. The derived diglyceride acetates were separated into different molecular species by argentation thin-layer chromatography. These analyses showed that 1-stearoyl, 2-arachidonoyl was the major species of brain CDP-diglyceride.

Animals↗