Search PubMed⌕ Search

Biomedical subjects

W Thomas

Publications and source records attributed to W Thomas.

At least 181 records · Page 10Linked to original sources
PubMed1978

Focal brain hyperthermia. I. The cerebellar cortex.

Focal brain hyperthermic methodology has been described and data presented on the cerebellum which show that enhancement of electrical activity of cerebellar cortex occurs when this method is used with careful monitoring of temperature. The duration of electrically induced cerebral after-discharges is shortened when cerebellar warming reaches 39.5--42.0 degrees C,. Since these effects are repeatable over many hours, there appears to be little, if any, resultant damage. Such induced changes in the cerebrum resemble those previously reported in which electrical stimuli were applied to the cerebellar cortex.

Animals↗
PubMed1978

Malacoplakia of the endometrium, a probable cause of postmenopausal bleeding.

A 60-year-old woman, 20 years post-menopausal, who had deforming rheumatoid arthritis of 7 years' duration and Sjögren's syndrome of 1 year's duration, had had postmenopausal bleeding for a month prior to admission to the hospital. A diagnosis dilatation and curettage was interpreted as showing acute suppurative endometritis. The patient was discharged, only to have recurrent vaginal bleeding. She was readmitted five weeks later, at which time results of another dilatation and curettage were interpreted as showing xanthromatous endometritis. Total hysterectomy with bilateral salpingo-oophorectomy was done. Examination of Epon-embedded endometrium 1 micrometer thick by light microscopy and subsequently by electron microscopy disclosed intracellular bacilliform organisms within phagolysosomes of atypical histiocytes, lamellar bodies, and various developing stages of calcospherites, Michaelis-Gutmann bodies. The curettings were then received and classic Michaelis-Gutmann bodies were identified in periodic acid--Schiff-stained sections.

Endometritis↗
PubMed1978

[On translocation surgery of the tendon of the musculus peroneus brevis (M. fibularis brevis) in clubfoot (author's transl)].

The paper reports on the basis of long-term observations on an old surgical method which used to be practised in infants before arthrolysis around the anklebone (pantalar arthrolysis) was employed in the treatment of insufficient lifting of the outer edge of the foot in clubfoot recidivation. This old surgical method consisted of translocating the tendon of the m. peroneus brevis (m. fibularis brevis) before the outer ankle bone. The method is described, and its mode of action is discussed. Results obtained with 14 operations of this kind, are presented.

Adolescent↗
PubMed1978

[Biomechanical aspects of arthrosis of the carpometacarpal joint of the thumb and its treatment with a special endoprosthesis].

The joint between the trapezium and the first metacarpal is anatomically like a saddle. In function, however, it is used like a ball and socket joint with the following possible movements: 1. Flexion - extension, 2. abduction - adduction, 3. opposition and circumduction. The movements in the two first planes are completely congruent, whereas in the third an incongruent motion of the joint is created by the rotation of the metacarpal on the trapezium. In this situation there is joint contact at one point only, being - biomechanically - a prearthrotic deformity as described by HACKENBROCH. Accordingly, the carpometacarpal joint of the thumb in normal use is exposed to special stress which can end in degeneration. When in arthrosis of the carpometacarpal joint of the thumb conservative measures fail, we replace the deformed joint by prosthesis having the construction of a ball and socket joint. The prosthesis (designed by FRANCOBAL) has a metallic part with body, neck and a sphereshaped head, and a polyethylene socket, which can be coupled to the head by a snap mechanism. Both parts are inserted with polymethylmetacrylate cement into the prepared bone of the trapezium and the first metacarpal. The advantages of this method are: no pain, stability of grip, and motion similar to that of a ball and socket joint. Because this motion is physiological, loosening of the implants and their insertions are avoided. The first 8 patients treated with this method show satisfying functional results. The longer follow-up time is 6 years.

Aged↗
PubMed1977

Stainable iron in aspirated and needle-biopsy specimens of marrow: a source of error.

Marrow iron was assessed in needle biopsy sections and in simultaneously obtained aspirated smears and aspirated clot sections from 251 patients. Significantly different amounts of stainable iron were observed in needle biopsy sections and aspirated smears in 15% of the specimens. The usual difference consisted of significantly less stainable iron in needle biopsy sections as compared to the aspirated smears (13%). Of clinical importance was the finding of absent stainable iron in 8% of the needle biopsy sections, in contrast to the definite deposits observed in the corresponding aspirated smear. Of similar interest was the observation that 6% of the needle biopsy sections had significantly less stainable iron than corresponding hemosiderotic smears. The amounts of stainable iron in needle biopsy sections were similar to the amounts observed in the corresponding aspirated clot sections. Evaluation of marrow iron using needle biopsy sections as well as aspirated clot sections differs from results observed in aspirated smears and could be a source of significant error in the assessment of iron stores.

Biopsy, Needle↗
PubMed1976

Chemotherapy of malignant diffuse mesothelioma.

The clinicopathologic features of six pleural and one peritoneal mesothelioma were analyzed. Six patients were treated with either adriamycin or a multiple drug regimen consisting of cyclophosphamide, vincristine, methotrexate, and 5-fluorouracil (COMF). Of those who received COMF, one obtained a complete response lasting 19 months and two had partial responses lasting 3 and 7 months. Adriamycin was administered to five patients. Two obtained a complete response lasting 19 and 7 months. Three had partial responses lasting 2, 6, and 9 months. Grading of response was often difficult requiring serial review of chest x-rays. Survival from diagnosis ranged from 2 to 39 months, with a median of 9 months. We conclude that adriamycin or COMF treatment may offer worthwhile remissions in mesothelioma and that malignant diffuse mesothelioma is more responsive to chemotherapy than previously realized.

Aged↗
PubMed1976

[Mature intraligamentary pregnancy with florid salpingitis tuberculosa (author's transl)].

Reported is a case of a 32 year old para II where an intraligamentary extrauterine pregnancy was terminated by caesarean section at term following spontaneous rupture of the amniotic sack. The newborn male weighed 3600 g, there were no malformations. There was a transient phase of asphyxia. Histologic examination of the placenta, that had developed in the mesosalpinx, the Fallopian tube and the uterus that had been amputated supracervically, showed to our surprise a florid caseating tuberculosis of the mucosa of uterus and Fallopian tube and also in a circumscribed area of the basal plate. After an initial uneventful course the newborn developed clinical manifestations of connatal tuberculosis on the 16th day of life. Whereas the mother died a few days after delivery, the baby survived the infection, this certainly was due in large part to the prophylactic tuberculostatic treatment that had been initiated immediately after the diagnosis of tuberculosis was made on account of histology. The case of an extrauterine pregnancy at term reported here differs from most of the previous reports by a) the site of the pregnancy, b) the development of a mature living newborn without malformations and in respect to b) it differs from all previous publications by the existing active caseating tuberculous salpingitis and endometritis of the mother, and the connatal tuberculosis of the newborn with its successful treatment.

Adult↗
PubMed1975

Arylsulfatse B in colorectal cancer.

Arylsulfatase B activity has been determined in 24-hour urine samples from 243 patients with colorectal cancer. Elevated activity of the enzyme was obsereved in 172 out of 243 (71%) patients. Employing Dukes' modified classification of colorectal cancer, urine arylsulfatase B activity was elevated in Dukes' A lesions-1/8 (12%), Dukes' B lesions-24/43 (55%). Dukes' C lesions-89/111 (80%), and Dukes' D lesions-66/81 (82%). Arylsulfatase B activity in urine, when elevated, may be used to follow response to therapy since in those patients with elevated urine arylsulfatase B values who subsequently responded to therapy, the enzyme values became or approached normal. Urine arylsulfatase B activity also correlated with plasma carcinoembryonal antigen (CEA) as a diagnostic indicator of colorectal cancer in 33/46 (71%) patients. In contrast to the urinary findings, arylsulfatase B activity in tumor tissue was elevated in only 24% (27/110) of the specimens of colorectal cancer. It was also found that in a group of 55 patients treated with 5-fluorouracil, all of the 13 patients that showed objective response to therapy had activities of arylsulfatase B in the tumor tissue within the normal range for large bowel mucosa. Nevertheless, 22 to 26 of the 43 patients that did not respond also presented values in the normal range. The roles of lysosomal enzymes in colorectal cancer are discussed.

Adult↗
PubMed1975

Parathyroid identification by methylene blue infusion.

The intravenous infusion of methylene blue was investigated as a procedure that would identify parathyroid glands during operation in 17 patients with primary hyperparathyroidism. The dye was found to stain all adenomas, most hyperplastic glands and occasionally normal parathyrodi glands. In addition, the frequency of glandular staining was directly related to the size of the gland, although size and histology may have been independent variables. Methylene blue infusion is a safe effective method of localizing abnormal parathyroid glands.

Adenoma↗