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Biomedical subjects

W Thoenes

Publications and source records attributed to W Thoenes.

At least 91 records · Page 5Linked to original sources
PubMed1976

Primary perireticulin amyloidosis in a 14-year-old girl.

A primary perireticulin amyloidosis is reported in a 14-year-old girl, which showed the symptoms of a steroid-resistant nephrotic syndrome. The diagnosis was established by biopsies of kidney and rectum. Occurrence of amyloidosis in childhood and the clinical picture are discussed and references to clinical trials carried out are given.

Adolescent↗
PubMed1976

[Nephrotic syndrome in infancy - a heterogenous disease. A case of sporadic connatal nephrotic syndrome (author's transl)].

The course of illness in a patient with connatal nephrotic syndrome is reported. It started already during the first week, renal failure was absent. The picture differs, however, from the congenital Finnish nephrotic syndrome in the following points: No family history, infection during pregnancy, unremarkable birthweight (3075 g) and weight of placenta (690 g), early micro-hematuria, and rise of IgM, arterial hypertension and partial sensitivity to steroids with incomplete remissions and finally duration of life of 1 year and 8 months. The difference from the Finnish type is confirmed with light- and electron-microscopy and immuno-fluorescence investigations. Morphological changes make it appear that it belongs into group 3 of nephrotic syndrome after Habib (16), with its minimal and focal glomerular changes. An attempt is made to devise a classification of the nephrotic syndrome during the first year of Life according to its cause. The importance of an absolute indication for renal biopsy is stressed.

Birth Weight↗
PubMed1975

Basement membrane-changes in membranoproliferative glomerulonephritis: a light and electron microscopic study.

This study is based on 31 renal biopsies from 28 patients with idiopathic membranoproliferative glomerulonephritis (MPGN). 18 cases were classified as "pure" MPGN, 10 as lobular GN. For light microscopy two staining procedures were found to be of particular value: Pearse trichrome (PAS+Orange G) and Jones-Chromotrope (methenamine silver + Chromotrope 2R). These techniques reveal conspicuous basement membrane (b.m.) lesions which are not observed in other types of GN and are characterized by thickening of the b.m. and a bright orange or red coloration, respectively, which can well be separated from normal (PAS-positive or argyrophilic) basement membranes. Electron microscopy was performed in 13 cases in order 1. to analyze the fine structure of this lesion, 2. to match the results with the current subclassification concept which is essentially based on the discrimination of intramembranous dense (IMDD) and subendothelial deposits. The typical finding of a continuous intramembranous electron-dense material which proves to be argyrophilic in ultrathin sections was present in 3 (23%) of the cases.

Adolescent↗
PubMed1975

[Perimembranous glomulonephritis in heapatitis associated with hepatitis B antigen (author's transl)].

Hepatitis B (HB) antigen was persistently found in two children with perimembranous glomerulonephritis. Soluble immune complexes were demonstrated in both instances. These circulating immune complexes were found only in serum fractions enriched with HB antigen. Immunohistology of sections of kidney demonstrated immune complexes in a granular pattern in the subepithelial regions of the glomerular capillary walls. Fluorescent HB antigen was found in the same region. HB antigen was also detectable in urine. Participation of the complement system in the progress of the disease was demonstrated quantitatively by a decrease in complement factors C1q, C4 and C3 in peripheral blood. Histological, including electromicroscopic, studies in both cases revealed diffuse thickening of the glomerular basement membrane with dense deposits of different extent, and spikes of the basment membrane. These studies strongly suggest an interrelationship between hepatitis with HB antigen and glomerulonephritis.

Adolescent↗
PubMed1975

The ultrastructural basis of permeability to proteins in normal and nephrotic glomeruli. Electron microscopic and micropuncture studies using ferritin as a tracer.

Following microinjection of ferritin into urinary space of the rat renal glomerulus in vivo, permeability of the visceral epithelial wall was examined with electron microscope. Results indicated that in normal glomeruli ferritin molecules can be retained by the slit diaphragmata of the eithelial cells; this suggests a barrier function of the slit diaphragmata. The nephrotic glomeruli, observations suggested a channel-like pathway to proteins penetrating the epithelial layer. The channel is formed by only one single cell and therefore, the term 'percellular channel' is proposed for that formation.

Animals↗