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Biomedical subjects

W Thimme

Publications and source records attributed to W Thimme.

At least 37 records · Page 2Linked to original sources
PubMed1976

[Consumption coagulopathy in a patient with metastatic renal carcinoma (author's transl)].

Chronic disseminated intravascular coagulation with secondary hyperfibrinolysis occurred in a patient with metastatic renal carcinoma. In the beginning the treatment with heparin was successfull. Heparindosage up to 35 000 E/day could never suppress this process completely. The value of determining thrombintime, concentration of fibrin splitting products, coagulation factors II, V, VII, IX, X and XIII, antithrombins II and III in controlling heparintherapy is discussed. Besides thrombintime and platelets the determination of fibrin splitting products is another substantial factor in controlling treatment of chronic intravascular coagulation. The patient died of myocardial rupture with heart tamponade, caused by a great intramyocardial metastasis.

Adenocarcinoma↗
PubMed1976

[Hospital care of patients with myocardial infarction in West Berlin (author's transl)].

An inquiry with Berlin hospitals on the care of patients with acute myocardial infarction revealed that only 30% were treated on wards guaranteeing optimum supervision and treatment according to their equipment and staff. The inquiry further shows which procedures have gained ground in the treatment of dysrhythmias and heart failure and in the prevention of thrombosis. An improvement of the care is to a lesser extent to be expected from the further development of costly therapeutical specialities but rather from administrative measures ensuring disease-specific admission to appropriate hospitals. This calls for authorities to attend to this task.

Acute Disease↗
PubMed1975

[Pressures, blood gases, pH, lactate and pyruvate concentrations in the portal venous blood in patients after laparotomy during the first 9 days (author's transl)].

In 24 patients (16 women, 8 men, mean age 60 years), who underwent abdominal operations and who had a uncomplicated postoperative course, a teflon-tube was inserted into the portal vein at the end of laparotomy and remained there for maximal 9 days. The mean values of the portal venous pressure as well as of the portal-central venous pressure gradient are unchanged during the period of all 9 days and are between 7,4 and 7,9 mmHg, between 5,6 and 6,9 mmHg respectively. The arterio-portal venous 0(2)-content difference shows in the mean no fluctuations and is about 2 Vol.%. On the first postoperative day the lactic and pyruvic acid concentrations in the artery and portal vein are moderately, but significantly elevated and decrease to normal values until day 7. - 9.

Adult↗
PubMed1975

Behavior of the portal vein system in man after laparotomy.

At the end of an abdominal operation, a Teflon catheter was inserted into the portal vein, where it remained for nine days. Thus, blood samples could be withdrawn for analyses, and pressures could be recorded. The investigations were carried out in 41 patients who had a gastric or intestinal operation and had an uncomplicated postoperative course. The pressures in the portal vein and the arterioportal oxygen content difference were constant with 7 to 8 millimeters of mercury and by 2 volume per cent, respectively, during the period of all nine postoperative days. The pressure gradient between portal and central veins was about 6 millimeters of mercury. By infusing 350 to 500 milliliters of dextran 60 on day one or two postoperatively, the cardiac output was elevated about one-third, the central venous pressure increased from 0.9 to 4.9 millimeters of mercury and the portal venous pressure increased from 7.8 to 9.7 millimeters of mercury. This means that the pressure difference between the portal and central veins diminished. Simultaneously, the oxygen content difference between the systemic and pulmonary artery decreased from 4.7 to 3.3 volume per cent and between the systemic artery and portal vein, from 1.8 to 1.3 volume per cent. By assuming a constancy of the oxygen consumption in the region of the mesenteric circulation during infusion, it can be calculated from the behavior of the arterioportal oxygen content difference that the flow increase in the portal vein nearly equals that of cardiac output. The physical transhepatic resistance decreased about 50 per cent.

Cardiac Output↗