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Biomedical subjects

W T Sause

Publications and source records attributed to W T Sause.

78 records · Page 5Linked to original sources

Abdominal lymphoma: lack of complete surgical staging.

At present there is no consensus on the optimal management of patients with abdominal lymphomas. One major obstacle in treatment planning is the lack of adequate surgical staging. A retrospective review of 33 consecutive patients presenting with abdominal lymphoma revealed that the initial surgical procedures were deficient in most cases. Frequent omissions were failure to biopsy the regional lymph nodes and liver, lack of splenectomy, and lack of adequate description of the spleen. Until prospective studies of various treatment regimens can be carried out in adequately surgically staged patients with abdominal lymphomas, no clear treatment recommendations can be made. Surgical staging should include description, biopsy, and (if possible) resection of the primary tumour; description and biopsy of involved and regional lymph nodes; biopsy of the liver; description of and (if possible) resection of the spleen; and bone marrow.

Abdominal Neoplasms↗

Radiotherapy of bronchogenic carcinoma. Analysis of a treatment schedule designed for use with hyperbaric oxygen.

All cases of bronchogenic carcinoma treated with curative intent over an eight-year period were reviewed. Most were treated with 12 X 400 rad in 32 days using 60Co, a schedule designed to optimize the radiation-sensitizing properties of hyperbaric oxygen. While O2 gave no obvious benefit, overall four-year survival was 10.6% and that of patients with good prognostic indicators was 18%. No radiation myelitis was observed. This protocol delivers an adequate tumor dose and appears to be tolerated well by most patients.

Adult↗

Extended field radiation therapy for prostate cancer: influence of positive lymph nodes on prognosis.

One hundred forty-eight patients with prostate cancer, treated with curative intent at the LDS Hospital from 1969 to 1977, were analyzed. Local control and survival were excellent in patients with negative lymph node evaluations. Eighty-six percent (24/28) were without evidence of disease at the time of this report. Patients with tumor in pelvic lymph nodes had a poor five-year disease-free survival, despite regional radiation therapy. At five years, 17% (13/18) were disease free. External beam radiation is excellent therapy for localized cancer of the prostate gland. The value of regional radiation in the presence of positive adenopathy remains to be defined.

Aged↗

Radiation therapy for skin cancer.

Local control, cosmesis and functional results were evaluated in 315 cases of skin cancer in 247 patients treated with radiation therapy. The initial recurrence rate for basal cell carcinoma was 7.8 percent and for squamous cell carcinoma was 14.9 percent. Ultimate local control was achieved in 98.7 percent of the cases of basal cell carcinoma and in 94.0 percent of the cases of squamous cell carcinoma with use of further irradiation or other therapeutic modalities. Ultimate local control rates were comparable to other therapeutic modalities. Cosmetic and functional results were excellent. Cartilage necrosis was not a significant problem. Radiation therapy may offer advantages in certain clinical situations and should be considered as a mode of therapy in the treatment of skin cancer.

Basal Cell Carcinoma↗