Biomedical subjects

W Szyfter

Publications and source records attributed to W Szyfter.

At least 19 recordsLinked to original sources

PubMed2006

Distortion product otoacoustic emission (DPOAE) in tinnitus patients.

The aim of this study was to determine the effect of tinnitus (experiment I) and the combined effect of tinnitus and sensorineural hearing loss (experiment II) on the distortion product otoacoustic emission (DPOAE) for two age groups of tinnitus patients. Tinnitus patients with normal earing, along with normal-hearing control subjects, participated in experiment I. They were divided into two age groups, below 50 and above 50 years. Experiment I showed that the DPOAE levels in the tinnitus patients were lower than those in the normal-hearing (nontinnitus) subjects. The differences depended on the frequency and the age of the patients, suggesting the confounding influence of presbyacusis. The second group of tinnitus patients with increasing and notch-like hearing loss participated in experiment II. They were also divided into two age groups, below 50 and above 50 years. The data from experiment II showed that DPOAE activity well reflects the increasing and notch-like hearing loss functions up to about 40 dB HL. The effect of age on the DPOAE level was clearly noted only for the tinnitus patients with clinically normal-hearing thresholds and was ambiguous for the tinnitus patients with hearing loss.

Adolescent↗

PubMed2003

Poznań's program of cochlear and brainstem implantation: a general review.

The cochlear implantation program in Poznań started in January 1994. Within 8 years, 151 patients were implanted (149 cochlear and 2 auditory brain-stem implants). The implanted group comprised 111 children and 40 adults. We have extended the lower age limit for cochlear implant candidates, and the youngest implanted patient was 18-months-old at the time of surgery. We have also implanted six multi-handicapped subjects. All patients were implanted with different nucleus devices (22, 24 M, 24 K, 24 Contour, 24 Double Array and 24 ABI). Insertion of the Nucleus 24 Contour electrode carrier requires a little larger cochleostomy in comparison with conventional straight array. After insertion, the intraoperative measurements are taken (impedance telemetry, electrically evoked stapedius reflex and NRT). The day after surgery, each patient undergoes an X-ray examination (the cochleogram or cochlear view). The calculated length of the electrode array insertion was 12.75-24.0 mm (mean: 22.05 mm) and the degree of electrode rotation was 180-540 degrees (mean: 292.82 degrees). After speech processor switch-on, we performed NRT measurements. Our results indicated that the NRT threshold was in 51.4% of the dynamic range within the group of examined patients. The adults' progress of rehabilitation was checked during individual sessions. The rehabilitation of children included two rehabilitation schedules: continuous ones and weekly rehabilitation camps. The progress of the recovery process of implanted children enabled them to change their school profile from hearing impaired to mainstream. Voice rehabilitation is often monitored by acoustic analysis using the Multi Dimensional Voice Program (MDVP).

Adolescent↗

PubMed2001

[An attempt to identify the most frequent genomic mutations responsible for isolated deafness in patients after cochlear implantation].

The aim of this study was to identify subjects with 35delG mutation of GJB2 gene as the most frequent genetic cause of deafness. Deaf patients receiving cochlear implantation at the ENT Clinic at University of Medical Sciences in Poznań and their family members were recruited to the study. Peripheral blood lymphocytes DNA was amplified in allele-specific PCR and analysed for single strand conformation polymorphism (SSCP) to detect mutation at DFNB1 locus. 35delG mutation at both alleles was found at 42.9% of deaf patients and 29.4% of health relatives were found to be carrier of the mutation at one allele. The study is thought to be a first step in analysis of typical mutations in Polish deaf population.

Adolescent↗

PubMed2001

[A case of objective tinnitus caused by palatal myoclonus].

The very rare case of palatal myoclonus manifesting in objective tinnitus was discussed. Options of surgical and pharmacological treatment were analysed with particular emphasis of therapeutic success with application of muscle-relaxant--Baclofen.

Baclofen↗

PubMed2001

[Anatomy of the temporal bone assessed by high resolution computed tomography, endoscopy and microscopy].

Visualization of all anatomical structures inside the middle ear is indispensable to perform surgical treatment. The aim of this study was the attempt to show landmarks of the middle ear employing different imaging techniques. The value of high resolution CT with 1 milimeter layers, Hopkins endoscopy and operating microscope with 16 time magnification were assessed. The primary evaluation by the CT scans were made and directed the further efforts. Endoscopy and microscopy were performed as a next diagnostic steps and allowed for tool-eye visualization of all important anatomical structures in the middle ear. The anatomy and pathology of tympanic cavity assessed by three different technics used together occurred to be much more detailed. The results were complementary and useful.

Endoscopy↗

PubMed2001

[A rare case of adenoid cystic carcinoma of the larynx].

One case of rare laryngeal tumor--adenoid cystic carcinoma in 58 year old woman was reported in this paper. Authors wanted to drew attention to few complaints and only slight dysphagia in comparison to local extensiveness of the neoplasm. Diagnostic difficulties were underline. Epidemiology, clinical course and therapy were demonstrated in laryngeal adenoid cystic carcinoma.

Aged↗

PubMed2001

[The quality of life in head and neck cancer patients: description of randomized examination formula based on standardized questionnaires EORTC QLQ C-30, EORTC QTQ-H-N35 and Kiel Questionnaire].

The notion of quality of life (QL) was first introduced in the US in the 50-ies. This notion is much broader then health, it is a personal, subjective feeling of well-being that comes from actual, widely-meant life experiences. The QL is not a measurable value, however, it may be assessed by means of appropriate indices. In the contemporary holistic attitude to a patient, in modern oncology, QL has become a parameter of equal importance to other values characterizing the treatment success, as important as numbers describing e.g. mean survival, disease free survival, or neoplasm controlled survival. Head and neck neoplasms bring about deterioration of the basic functions of the organism such as: breathing, swallowing, speaking and senses: hearing, taste and smell. Application of treatment may intensify pain, dyspnea, hoarseness or cause any kind of discomfort. It influences directly the patients' family and social life. Comparison of QL of patients treated for larynx, tongue, tonsill, glands, and paranasal sinuses neoplasms depending on localisation of primary foci, advancement of the disease, the applied treatment and its radicality, age, sex, place of living (town/country), and educational level. Correlation between the subjectively assessed QL and the objectively evaluated condition of the patient is measured. In ENT Dept. K. Marcinkowski University of Medical Sciences 46 patients were examined from May to September 2000. EORTC QLQ C-30, EORTC QLQ-Head and Neck and HAD scale were used. Kiel Questionnaire was introduced in September. The main reason for introducing it was the fact, that surgery is the method of choice in the treatment of head and neck malignancies in our Dept. The team composed of a psychologist and an ENT doctor has been working together on objective assessment of each patient. The QL assessment may be of practical importance when trying to improve the model of health care in cases of oncological patients. This knowledge enables us to learn how the accompanying side effects of therapy influence the QL of our patients, and how these problems may be overcome by proper education, advice, and support provided by the qualified staff. The authors are evaluating the QL in the period of 2, 6 months and 1 year after surgery in patients not supported psychologically. Our goal, in the future, is to introduce the psychological treatment, i.e. repetitive meetings in small groups, conducted by a psychologist. We have contacted 4 major ENT centers in Poland in order to coordinate the research on detailed assessment of QL in Head and Neck Cancer Patients in Poland. The results will be presented in the further publications.

Carcinoma, Squamous Cell↗

PubMed2001

[Intracranial complications of sinusitis in the material of the Otolaryngology Department, K. Marcinkowski University of Medical Sciences in Poznań in the years 1964-1999].

In the period of 35 years 25 patients with intracranial complications of paranasal sinusitis were treated in the Department of Otolaryngology of the Karol Marcinkowski University School of Medical Sciences in Poznań. In the past 15 years the number of complications decreased annually by half. Intracranial sinusal complications were more frequently present in young men. In 25 patients abscesses of the frontal lobe and epidural abscesses were most often diagnosed. Surgical treatment was carried out in each case when the inflammation process spread into the bony parts or into intracranial space. The method of choice in treatment of frontal lobe abscess and subdural abscesses is elimination of sinuses inflammatory foci with a simultaneous evacuation of the abscess by puncturing of the abscess and gradual exchange of its content into antibiotic solution. Intensive antibiotic therapy was carried out for the period of 4 weeks. Mortality rate in our material concerned patients with the brain frontal lobe abscesses and amounted to 12%. In the last 15 years we succeeded to treat all 17 patients.

Adult↗

PubMed2001

[Cochleography and cochlear view as the way of assessment of successful surgical inner ear implantation].

115 cochlear implantation were performed in ENT Department Karol Marcinkowski University of Medical Sciences in Poznań in 1994-2001. Nucleus Mini System 22 and Nucleus 24 of Cochlear Ltd were used in these operations. Two approaches were performed: middle fossa approach in one case and traditional one. The aim of this study was evaluation of cochleogram and cochlear view as the ways of assessment of successful inner ear implantation. One of X-ray projection were performed in implanted patients 24 hours after implantation. In cochleograms the degree of electrodes rotation in cochlea was calculated. The number of inserted electrodes in cochlea was calculated in cochler view projection. Described X-ray projection were performed in 70 patients. On X-ray projection (cochleograms) rotation degree of electrodes in majority were equal or higher than 250 grades (according to literature it is sufficient for successful speech rehabilitation). X-ray projection--cochlear view confirmed full insertion of electrode.

Cochlea↗

PubMed2001

[Cochlear implantation through the middle fossa approach].

The inner part of cochlear implant is inserted into inner ear during surgery through mastoid and middle ear. It is a classical method, used in the majority cochlear centers in the world. This is not a suitable method in case of chronic otitis media and middle ear malformation. In these cases Colletti proposed the middle fossa approach and cochlear implant insertion omitting middle ear structures. In patient with bilateral chronic otitis media underwent a few ears operations without obtaining dry postoperative cavity. Cochlear implantation through the middle fossa approach was performed in this patient. The bone fenster was cut, temporal lobe was bent and petrosus pyramid upper surface was exposed. When the superficial petrosal greater nerve, facial nerve and arcuate eminence were localised, the cochlear was open in the basal turn and electrode were inserted. The patient achieves good results in the postoperative speech rehabilitation. It confirmed Colletti tesis that deeper electrode insertion in the cochlear implantation through the middle fossa approach enable use of low and middle frequencies, which are very important in speech understanding.

Adult↗

PubMed2001

[Contribution to etiology of otitis media with effusion].

BACKGROUND: Otitis media with effusion is characterized by gathering and retaining of effusion within the tympanic cavity and the structures of the mastoid bone. The aim of this study was to explain the role of immunological reaction in pathogenesis and development of this disease. MATERIAL AND METHOD: The studied group comprised 6 patients aged between 7 and 14 years. The effusion present within the tympanic cavity was aspired and then the agarare gel immunoelectrophoresis was performed. After 24 hours the precipitation stripes of the IgA and IgG were analysed. Blood serum specimens were also collected in the studied group. After centifrugation, blood serum concentrations of IgA and IgG were evaluated. RESULTS: IgA and IgG were present in the effusion taken from the tympanic cavity in all examined cases. The level of IgA was higher in older individuals.

Adolescent↗

PubMed2001

[Otoacoustic emission evaluation in patients with tinnitus].

Analysis of otoacoustic emission is highly objective, noninvasive and sensitive method representing cochlear function. In The Centre of ENT Rehabilitation in Poznań more than 900 patients were evaluated because of tinnitus. Standard tests were broaden by otoacoustic emission (SOAE, TEOAE, DPOAE) and results are discussed. Our results suggest that otoacoustic emission is possible to record in normally or with moderate hearing loss patients. 18 patients had SOAE. Only 2 patients had the same frequency of SOAE and tinnitus.

Adolescent↗

PubMed2001

[Epidemiology of acoustic neuromas in Poland].

In 1996 the Polish Skull Base Surgery Society was founded and assembled mainly otolaryngologists and neurosurgeons from several dozen clinics and hospital wards. Its main aim was to encourage co-operation between those two specialties. For this reason among others a common project entitled: "Epidemiology of acoustic neuromas in Poland" was launched in 1997. Information was collected from questionnaires in seven neurosurgery and in three laryngology centres in the years from 1997-1998. So far, no epidemiology of acoustic neuromas was established for the population of Poland. In this span of time 72 patients were operated. The agreement upon similar criteria, terminology and ways of evaluating the treatment results was quite a problem. Most cases were found in patients in their fifties (19 cases) and sixties (15 cases), mostly women. The average duration of the symptoms was 43 months. Large tumours predominated in the study group--T4 in the Samii (67%), and > 26 mm in the Tos (74%) classification. Most commonly, the patients were subjected to computer tomography in the preoperative period. All patients were treated surgically, with the retrosinusoid approach predominating. Only in one case, the translabyrinthal approach was used. Authors of this work are all participants of the project. Despite the fact that the number of performed operations is not too high, the fact of co-operative studies on the results by representatives of those two specialties can be considered a success. Hopefully, in the next years it will gradually be possible to widen the scope of the project and obtain more precise information.

Aged↗

PubMed2001

[Does the electrodes insertion depth influence speech rehabilitation progress in CI patients?].

Many interdisciplinary teams from difference CI centers are studying speech rehabilitation process of implanted patients. Speech rehabilitation progress depend on many conditions like: duration of deafness, age at implantation, cause of deafness. Rehabilitation of postlingually deafened patients is very short. These subjects return very fast to the world of sounds. By the other side speech rehabilitation of prelingually deafened patients needs much more time (years). There are although well seen differences in language skills acquisition inside these groups. It confirmed, that speech rehabilitation after cochlear implantation could depends on others conditions as well. The aim of this study was electrodes insertion depth evaluation (cochleograms) and its influence on speech rehabilitation progress.

Cochlear Implantation↗

PubMed2001

[Comparison of DNA adducts between oral, pharyngeal and larynx cancer].

The results concerning examination of DNA adducts in oral (23 patients), pharyngeal (23 patients) and larynx cancer (10 patients) subjects are presented. DNA adduct levels were compared in respect to anatomical structure (primary tumour location), number of cigarettes smoked, TNM stage, and age of patients. DNA was isolated from removed tissue (tumour and non-tumour surrounding tissue) using detergent/phenol extraction. 32P-postlabelling assay including nuclease P1-enhancement modification was applied. Aromatic DNA adducts were found in all studied tissues. Total DNA adduct levels (tumour and non-tumour tissues) was lowest in larynx cancer, higher in oral cancer and highest in pharyngeal cancer. There were no influence of age into formation of DNA adducts. The higher level of DNA adducts was found in tumour tissue of oral cancer in the group of smokers with metastasis into lymph nodes.

Adult↗

PubMed2001

[The Erbium-Yag laser in stapes surgery].

Laser has been used for 21 years in otology. This technique was introduced to decrease the number of complications after micromanipulations within the middle ear. Continuous-wave laser and pulsed laser have clinical application. In the ENT Dept. in Poznań pulsed Er-Yag laser (Zeiss Corp.) is used in the treatment of otosclerosis. First experiences and results of treatment of 35 patients using this method were presented. In all patients recovery of hearing was observed. No damage of the inner ear (deafness or hypoacusis) was found.

Adult↗

PubMed2001

[Usefulness of questionnaire EORTC QLQ C-30 and EORTC QLQ H&N C-35 in assessment of quality of life before surgical treatment in patients with head and neck cancer].

BACKGROUND: Quality of life (Qob) has become an important issue in head and neck cancer. Nowadays the explanation of factors predicting quality of life after surgical treatment has important role and implications for patient's management. METHODS: We analyzed which pretreatment parameters and factors predicted QoL after surgery of 46 patients with larynx cancer. The patients completed the EORTC Core Questionnaire, the Head and Neck Module. RESULTS: The QLQ H&N35 Core Questionnaire demonstrated acceptable reliability. The instrument was sensitive to the effect of patients' disagreement of quality of life state. Scores were significant associated with total quality of life score. CONCLUSIONS: Results support the sensitivity and applicability of Core Questionnaire. The use of this disease-specific measure to assess quality of life among patients with advanced larynx cancer.

Female↗

PubMed2001

[Role of sentinel lymph nodes in treatment of head and neck cancer].

Current points of view on significance of sentinel node biopsy in No-neck are presented and at the same time is pointed out the importance of this technique for the detection of occult cervical metastases. Methods of identification of the sentinel lymph nodes are described. Usefulness of the handheld gamma probe to determine the position of sentinel nodes during operative procedure was emphasised.

Gamma Rays↗