Biomedical subjects

W Strecker

Publications and source records attributed to W Strecker.

At least 37 records · Page 2Linked to original sources

PubMed2000

[Tuberculous spondylitis of the cervical spine].

WHO estimates that worldwide more than 4 million people are infected with tuberculosis (TB), 95% of them living in third world countries. TB is once again the most frequent infectious disease [1, 2, 7]. Extrapulmonary forms (EPTB) frequently appear with HIV-associated TB [3, 4, 6]. We present the case of a 23-year old patient with abscess forming TB of the right apical lung with infiltration and partial osteolytical destruction of the 7th cervical- and the first thoracal vertebral body. Progressive spinal compression lead to partial sensomotorical deficits. Surgical revision of the abscess, an atypical resection of the right apical lung and right wing hemilaminectomy of Th1/2 for spinal decompression became necessary. The spinal stabilisation was achieved by conservative treatment for 6 weeks only by a Minerva cast and for another 8 weeks by a cervical stiffneck. Following mobilisation was without problems and the neurological deficits subsided within 3 months. Clinical examination and functional X-rays analysis proved vertebral stability and good function. The treatment of TB is basically conservative. Surgery is only recommended in case of functional and infectious complications.

Abscess↗

PubMed2000

[Minimal invasive implant removal after retrograde intramedullary nailing of the distal femur].

Recently, the retrograde femoral nailing has become a procedure with increasing acceptance. Indications for the retrograde femur nail are distal femoral fractures including dia- and transcondylar fractures, supracondylar osteotomies and distal periprosthetic femur fractures after total knee joint replacement. Controversial discussion is carried on about the implant removal, which is potentially afflicted with further damage to the knee joint. To minimize the operative damage due to the implant removal, an arthroscopic assisted procedure has been selected. The arthroscopic assisted implant removal was possible in all of our patients. Intraoperatively, 2/3 of the patients showed normal age-related findings of the chondral and meniscal structures. The arthroscopic assisted implant removal is a gentle procedure, which allows minimal invasive extraction of retrograde femur nails and prevents secondary damage to the knee joint due to the otherwise difficult localisation of the implant. The advantages of this procedure concerning gentleness and diagnostic capabilities are as convincing, that we indicate implant removal of retrograde femur nails in all younger patients (< 60 years), except in periprosthetic fractures.

Arthroscopy↗

PubMed2000

Association of endotoxemia and production of antibodies against endotoxins after multiple injuries.

BACKGROUND: Endotoxemia after injury has been a controversial issue. Endotoxins stimulate the innate and adaptive immune system. OBJECTIVE: To investigate endotoxemia and its effects on the production of antiendotoxin antibodies of cultured mononuclear cells of patients with multiple injuries. METHODS: Blood samples of 20 patients with multiple injuries were collected up to 12 days after trauma. The endotoxin concentration was measured in the plasma, and mononuclear cells were isolated and cultured. Specific antibodies against two lipopolysaccharides, one lipid A preparation, and alpha-hemolysin of Staphylococcus aureus were measured in the cell culture supernatant by an enzyme-linked immunosorbent assay. RESULTS: Endotoxemia peaked at admission of the patients, decreasing thereafter to almost normal values within 5 days. Isolated mononuclear cells synthesized antibodies against all tested antigens with a peak at or between day 5 and day 7. The increase was significant for immunoglobulin (Ig)A and IgM specific to all endotoxins tested and for IgA specific to alpha-hemolysin. However, there were no significant changes of the concentrations of total IgM, IgA, and IgG. All specific IgG remained unaffected. CONCLUSION: Patients with multiple injuries initially have temporary endotoxemia. Endotoxin may be suggested as a stimulator of the synthesis of antiendotoxin antibodies, in particular of the IgA and IgM class in patients with multiple injuries.

Adult↗

PubMed1999

[Not Available].

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Journal Article↗

PubMed1999

[Graphical analysis and operative technique of single-cut osteotomy for complex femur deformities].

The correction of complex long bone deformities with concurrent bending, twisting and shortening is primarily based on complex preoperative planning. Up to now, wedge-shaped cortico-spongiose osteotomy has usually been performed. The single cut osteotomy requires more complex mathematical calculations and was therefore less frequently undertaken. In this paper, we present a graphical approach to define the plane of the single-cut osteotomy without any calculations. The resulting osteotomy allows a simultaneous correction of a deformation in the coronal and sagittal planes, as well as a coexisting torsional error. The advantages of this graphical approach are evident. Preoperative planning is significantly simplified and abbreviated as mathematical calculations are no longer needed. Furthermore, the precision by which the osteotomy plane is defined is not decreased by application of this method. However, the osteotomy should be done preoperatively in a model.

Bone Malalignment↗

PubMed1999

[Sonographic imaging of leg geometry].

Posttraumatic malalignments are a frequent sequlae of IM nailing of lower extremity fractures. Conventional US has proven to be inferior to CT determinations of tibial or femural length and torsion. A new 3-D US method is presented that allows for accurate single step determination of lower extremity length and torsion without ionizing radiation. A regular US machine with a 5 Mhz linear probe is combined with an US localizer. Reference markers affixed to the lower extremity eliminate errors associated with patient position or motion. The 3-D US method was compared against CT (Ulm's method) in the measurement of torsion and length of the tibia and femur in 50 adults and 50 children. In both methods, the maximum difference of the intraindividual torsional angles and length measurements was 7 degrees and 7 mm. The maximum standard deviation for reproducibility in length measurement was 1.6 mm and 1.5 degrees for angular torsion. The new 3-D US technique was superior to CT in terms of reliability and reproducibility. Clinical advantages of the 3-D US technique include rapidity, independence from patient motion or positioning and the avoidance of ionizing radiation. Indications for 3-D torsional and length determinations include follow-up evaluation of adult and pediatric tibial and femoral fractures, pediatric limb and gait evaluations, and osteotomy planning.

Adolescent↗

PubMed1999

Clinical experience with PDS II augmentation for operative treatment of acute proximal ACL ruptures--2-year follow-up.

The results of prospective anterior cruciate ligament (ACL) refixation in 33 patients with high proximal rupture is reported at 20-28 months' follow-up: mean age was 31.1 +/- 12.5 years. The surgical technique was a specially developed refixation of the ACL using a multiple suture loop (modified Marshall technique) augmented with intra-articular PDS II (polydioxanon, resorbable, Ethicon, Hamburg, Germany) to avoid derangement of blood circulation and to guarantee early functional rehabilitation. All patients were operated on within 7.3 +/- 4.5 days after injury. According to the IKDC evaluation score, 22 patients showed excellent and 10 patients good subjective function. Twenty regained their pre-injury level of activity. Anterior stability was tested manually and by KT-1000 max (Medmetric, San Diego). Twenty-eight patients had a firm end-point, although there was a positive Lachman test in 16 patients. Maximal joint laxity as measured by KT-1000 showed a 1-2 mm, 3-5 mm, 6-10 mm and > 10 mm anterior drawer for 16, 14, 2 and 1 patients, respectively. Twenty-five of the evaluated knee joints had a negative pivot shift test. Three patients had a limited range of motion. The potential advantages of PDS II-augmented refixation of acute proximal ACL ruptures are anatomic reconstruction without destruction of other anatomic structures used as grafts, early functional rehabilitation and possibly better proprioception.

Absorbable Implants↗

PubMed1999

Ultrasound evaluation of gravity induced anterior drawer following anterior cruciate ligament lesion.

Ultrasound is not so far a standard procedure to visualize the anterior drawer following anterior cruciate ligament (ACL) lesions. This is because the described techniques are either technically difficult or depend on the experience of the performer and are not standardized. The purpose of this prospective analysis on ACL intact, ACL deficient and ACL reconstructed knees was to compare the diagnostic accuracy of prone ultrasonographic Lachman testing with KT-1000 measurements in the same study population. Our technique is based on a prone position of the patient. The thigh lies on the table surface such that the patella has no contact. The lower leg is placed on a roll in the ankle area and flexed to 30 degrees . The transducer (5 MHz) is positioned over the medial aspect of the popliteal fossa to visualize the femoral condyle as well as the tibial head. Under ultrasound control the lower leg is manually lifted as far the thigh stays in contact with the surface defining the start position. The lower leg is then released and drawn by gravity into the anterior drawer position, the final position. The distance between the posterior tangent from the medial femoral condyle to the medial tibial plateau was registered by three independent ultrasound measurements of the injured knee. The uninvolved opposite knee served as an internal control. The same procedure was done using a KT-1000 device (89 and 133 Newton and manual maximum force). The patients were split into two groups: acute injury (A), and (B) 6 months following ACL repair with a patellar tendon graft. All patients then underwent arthroscopy. In group A with acute ACL lesions the anterior drawer resulted in 14.1 mm (+/- 3.5) and was significantly (P < 0.001) different from the contralateral knee (7.7 mm +/- 2.9). The KT 1000 showed a comparable difference with 14.4 mm (+/- 3.9) for the injured knee and 8.3 mm (+/- 3.4) for the uninjured (P < 0.001). Sonometrically, group B patients showed no clear difference between the repaired (9.9 mm +/- 2.7) knee and its control (8.1 mm +/- 2.5). This was found for the KT-1000 results as well. The results derived from the ultrasound evaluation of the anterior drawer correlated well with those from the KT-1000 (r = 0.46). Based on a minimum intra-individual difference of 5 mm in the ultrasound measured anterior drawer, the sensitivity of the test in group A resulted in 0.96, and the specificity in 0.98. The described technique is reproducible, painless and easy to perform in order to evaluate acute ACL tears using any commercially available ultrasound device. The reproducibility is similar to the KT-1000 device. We recommend this technique for use in cases of acute ACL tears as well as in the follow-up of ACL repair.

Adolescent↗

PubMed1999

Early biochemical characterization of soft-tissue trauma and fracture trauma.

OBJECTIVE: The long-term outcome of trauma patients basically depends on the relation between the clearance capacity of the organism, e.g., the lungs, and the antigenic (inflammatory) load in relation to the amount of damaged and perfused tissue. It is necessary to determine quality and quantity of fracture and soft-tissue damage by clinical means as early as possible. It is unknown whether biochemical markers and the impact of soft-tissue trauma correlate and whether there is a predictive value on clinical outcome. METHODS: A total of 107 trauma patients were prospectively enrolled in the study. Blood samples were collected immediately at the site of accident, at hospital admission, and every 2 hours for an interval of 24 hours, then daily. In addition to the biochemical analysis of 20 different substances, the following data were collected and correlated to the laboratory results: Injury Severity Score, polytrauma score of Hannover, modified fracture index, and soft-tissue index. These primary clinical findings as well as the laboratory data were correlated to criteria of clinical outcome such as length of stay in the intensive care unit, length of hospital stay, infections, systemic inflammatory response syndrome, sepsis, multiple organ failure score according to Goris, and finally to primary (< 72 hours), secondary (> 72 hours), and overall lethality. The determination of individual extent and severity of soft-tissue trauma is based on standard partial body volumes derived from healthy volunteers. In addition, clinical estimation of the degree of soft-tissue damage according to the usual classifications was performed. RESULTS: Significant (p > 0.05) correlations were found between fracture as well as soft-tissue trauma and intensive care unit stay, hospital stay, infections, systemic inflammatory response syndrome, multiple organ failure score, serum concentrations/activities of serum interleukin-6 and -8 and creatine kinase during the first 24 hours after trauma. Severe soft-tissue trauma was related to secondary lethality, however, without statistical significance. CONCLUSION: The amount of fracture and soft-tissue damage can be estimated early by analysis of serum interleukin-6 and creatine kinase and is of great importance with regard to long-term outcome after trauma.

Adolescent↗

PubMed1999

[CT determination of leg length and torsion in children and adolescents].

Because of different projections and axis constructions, the length and torsion of the lower extremities are sensitive to the measuring method. To judge pathological deformities in children or adolescents it is necessary to know the reference values. In this study, 78 children and adolescents 2-18 years old were included who had a femoral or tibial shaft fracture. Torsion and length were determined by computed tomography at least 3 months after internal fixation according the Ulm method. Only healthy bones were considered for this study. The mean internal torsion of the femur decreased during the growth period from 34.2 degrees +/- 10.3 degrees (x +/- SD) to 19.3 degrees +/- 9.5 degrees. There was only a weak correlation between the age and torsion of the femur. The mean external torsion of the tibia was 32.3 +/- 10 degrees. The 95th percentiles of the intraindividual torsional differences were 14 degrees (x = 4.1 degrees) of the femur (n = 30) and 12 degrees (x = 4.7 degrees) of the tibia (n = 48). The median femoral and tibial intraindividual length differences were 2 mm. The corresponding 95th percentiles were 10 and 9 mm. The aim of the study was to determine the age-dependent torsion and length and their respective differences with a standardized CT method. The range of the normal values was much greater than published in the literature.

Adolescent↗

PubMed1998

[Analysis of leg geometry--standard techniques and normal values].

The diagnosis of malalignments of the lower extremities includes analysis of the geometry of the whole leg. The first step in the diagnostic process is a standardized physical examination. It provides valuable background information for an effective radiological diagnosis. Even with a thorough standardized physical examination it is not possible to define exactly the deformity or decide on an operative procedure. The diagnosis of axis deviations in the frontal plane can be measured on a conventional plain X-ray of the whole leg. In this view it is very important that the knee joints are in a true a.p. view independent on torsional deformities of the lower legs. Today the gold standard to measure the torsion and length of the lower extremities is the CT scan. However, the multitude of analytical methods for CT measurements described in the literature do not lend themselves readily to comparison; thus, it is difficult to identify a clear method of choice. Not every CT measurement is better than a physical examination. Evidence of reproducibility and accuracy is a prerequisite for useful interpretation of the results. Up to this point in the literature there are only reference values for the Ulm CT Method. One alternative is the MR scan, which avoids radiological risks, but the reproducibility and accuracy of the MRI method are not as good as for the CT method. Another alternative is ultrasound, where recent advances in the measurement of torsion and length of the lower extremities have proven competitive with or superior to the accuracy of MRI. The three-dimensional determination of the torsion and length of the lower extremities by ultrasound has now assumed a leading role in the non-radiological diagnosis of malalignments of the lower extremities in children and adolescents. This method furthermore is increasingly being used in preoperative planning of leg deformities in adults.

Adolescent↗

PubMed1998

[Osteotomy of the proximal femur for correction of post-traumatic changes].

Basically, four post-traumatic conditions of the proximal femur can be improved by corrective osteotomies: recurring luxations and subluxations of the hip joint; necrosis of the femoral head; non-unions; deformities. Dependent on the individual situation, the following procedure can be recommended, including diagnosis of deformities and indication and therapy of corrective osteotomies: analysis of the problem from the viewpoint of history, clinical findings and imaging techniques; indication for corrective osteotomy; graphic planning; operation technique. Particularities of post-traumatic conditions with regard to diagnosis, indication and surgical technique are indicated. Only with perfectly tailored concepts can we respond to the individual situation of an individual patient and reflect the variety and complexity of post-traumatic conditions of the proximal femur.

Bone Lengthening↗

PubMed1998

[Single corrective osteotomy after knee para-articular fractures].

Post-traumatic malalignment can occur on one or several planes following fractures in close proximity to the knee joint. In a clinical and radiological analysis of deformities, the frontal, sagittal and longitudinal alignment, as well as differences in femoral or tibial length and torsion, must be taken into account. The location of the correctional osteotomy is usually defined by the center of the angular and torsional deformity. Of decisive importance when choosing the site of the osteotomy are the local quality of bone and the soft tissue envelope, the condition of the articular cartilage in the different compartments of the knee, the stability of ligamentocapsular structures and preexistent deformities of the distal femur and proximal tibia. Therefore, the location of correctional osteotomies must be modified, depending on the individual situation. The appropriate approach and technique must be chosen from the different available operative techniques. Inaccurate planning and inappropriate operative techniques pose severe risks. Specific postoperative complications are compartment syndromes, nerve irritation and infection.

Bone Malalignment↗

PubMed1998

[Plica syndrome as a cause of recurrent knee complaints].

In a series of 1850 consecutive knee arthroscopies between 1991 and 1995, plicasyndrome was diagnosed and resected by arthroscopy in 102 patients (5.5%). Clinical response was evaluated for 38 of 54 patients with an isolated plicasyndrome by use of a modified Lysholm questionnaire at an average follow-up of 31 months (range, 8-78 months). Excellent or good results were obtained in 90% of 21 patients without plica-induced lesions of the cartilage (group 1) and poor results in 10%. Only 64% of 17 patients with plica-induced lesions of the cartilage (group 2) had excellent or good results. Both groups showed an improvement for range of motion and swelling post-operatively. The mean time for rehabilitation was 3.2 and 1.7 months for patients with and without cartilage lesions, respectively.

Adolescent↗

PubMed1998

[Arthroscopic stabilization of anterior shoulder instability with bioresorbable tacks].

We examined 38 patients with an arthroscopic bioabsorbable tack repair for anterior shoulder instability in a prospective evaluation. The mean follow-up was 22 months (range 12 to 33). The average age was 28.4 years (range 15 to 57), the operation was performed at average of 50 months (3 to 244 months) after injury. Assessment using the Rowe score revealed excellent results in 33 and good results in 3 patients. 1 patient had a fair result and 1 had a poor result. 26 should obtained full range of motion, 11 had minor (< 10 degrees) loss of external rotation, 1 experienced greater (< 20 degrees) loss of external rotation. 3 of the 38 patients (8%) had recurrent instability, 1 patient with 2 preceding operations and atraumatic and voluntary dislocation, respectively. The recurrence rate of arthroscopic Bankart repair with bioabsorbable tacks are comparable to open Bankart procedures. Success of the procedure depends on appropriate surgical technique and suitable selection of patients with unidirectional, posttraumatic, anterior instability who are found to have well-developed ligamentous tissue.

Adolescent↗

PubMed1998

[Detection of NO liberation in the early phase of trauma].

Both, burn trauma and sepsis induce the generation of reactive oxygen intermediates which often coincides with increased nitric oxide (NO) levels. NO takes part in both circulatory disorders and cell protection. Therefore, in a prospective (pre-)clinical study we focused on the detection of NO in polytrauma patients (pts) starting as early as at the scene of accident. Upon approval of the local ethics committee, pts with an injury severity score (ISS) ranging from 9 to 75 (mean 22) were enrolled. Subsets were performed according to the different injury pattern (long bone fractures, head injury, polytrauma with and without damage to the thorax, isolated chest trauma). The first blood sample was obtained at the scene of accident. Then, blood was collected in hourly to daily intervals. NO production was assessed by the nitrate + nitrite plasma levels. To eliminate dilution effects following volume substitution, all values were recalculated on the plasma protein content. Immediately after trauma, NO plasma levels were elevated. This was most pronounced in pts that have experienced thoracic injuries irrespective of with or without additional polytrauma. There is evidence that NO production always starts immediately after major trauma but depends on the individual trauma pattern. In addition, the results reveal that lethal outcome is associated with an increased NO generation in the early post-injury period. We conclude that NO overproduction does not necessarily prime an overall protection in patients that have suffered from mechanical trauma. The role of NO after severe trauma and especially in thoracic injury should further be elucidated in a specific study on that topic.

Adult↗

PubMed1998

[Analysis of leg geometry].

Analysis of bony geometry of the lower limb comprises frontal, sagittal and longitudinal alignment, as well as length and torsion, including at first the whole leg and finally the femur and tibia separately. Clinical examination assesses the bony geometry, functional aspects, ligamentous and soft tissue conditions, etc. Frontal and sagittal radiographs indicate axial alignment and angles of the hip, knee and upper ankle joint. Apex and size of deformities are defined simultaneously. CT and ultrasound techniques allow the measurement of length and torsion of the whole leg, as well as of the femur and tibia separately, provided those techniques are standardized with proven reproducibility.

Bone Malalignment↗

PubMed1997

Is the activity of soluble CD14 enhanced following major trauma?

BACKGROUND: The molecule CD14 acts as a receptor for the protein-bound endotoxin (lipopolysaccharide [LPS]) complex and mediates the cellular effects of LPS. The soluble formation, sCD14, is supposed to neutralize circulating LPS (i.e., LPS antagonist) or transfer LPS effects to endothelial cells (i.e., LPS agonist). OBJECTIVE: To elucidate the release of sCD14 per se in patients with major trauma in the early posttrauma period. Our a priori hypothesis was that sCD14 release depends on the plasma LPS concentration simultaneously measured. PATIENTS: In a prospective study, 65 patients with multiple injuries (Injury Severity Score, 9-75) were enrolled. The patients were rescued by the medical helicopter service and directly admitted to our clinics. The plasma concentrations of sCD14 (enzyme immunoassay) and LPS (chromogenic limulus amebocyte lysate test) were analyzed. The first blood sample was collected immediately at the accident site. The following samples were drawn at intervals from 2 hours to daily for 2 weeks. RESULTS: Sixty-one patients survived the observation time. Immediately after trauma, their mean sCD14 level was not different from that of healthy individuals. Two hours later, a pronounced increase of sCD14 was observed and sustained throughout the observation period. Even nonsurvivors showed an increased sCD14 release, but less pronounced. In all patients, plasma LPS levels were elevated during the first 12 hours. CONCLUSIONS: Major trauma caused an increased release of sCD14. This elevation, however, was not correlated to LPS levels or to the severity of trauma (estimated by trauma scores). We found no evidence that sCD14 levels are of prognostic value regarding survival. Furthermore, the release of sCD14 did not occur in an LPS-neutralizing manner, but rendered possible an LPS-independent mechanism.

Adolescent↗