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Biomedical subjects

W Siegmeth

Publications and source records attributed to W Siegmeth.

At least 19 recordsLinked to original sources
PubMed1995

[Fibromyalgia].

Fibromyalgia, also called (primary) fibromyalgia syndrome or fibrositis (syndrome), is a chronic soft tissue pain syndrome characterized by the presence of widespread musculosceletal aching, tender points at characteristic sites, fatigue, and poor sleep. The etiology of this common and painful condition is incompletely understood, non-restorative sleep, which has been correlated with an electroencephalic abnormality called alpha-delta sleep (intrusion of alpha rhythms in the non-REM sleep EEG), may be important. Several observations suggest that serotonin is likely to mediate both pain and non-REM sleep, and serotonin deficiency in the brain has been suggested to be of pathogenetic significance in fibromyalgia syndrome. A lower than normal threshold for pain can often be observed. The newly proposed criteria for the classification of fibromyalgia syndrome (widespread pain in combination with tender points at 11 or more of 18 specific tender point sites) are important for the differential diagnosis and to compare results in international studies.

Cerebral Cortex↗
PubMed1995

[Intra-articular injections in arthrosis of the small and medium size joints].

Intraarticular injections into small and medium-size osteoarthritic joints may play an important role in the therapeutic plan. However, they are merely indicated if synovitis (with or without effusion) is present. Apart from irritating factors such as detritus or proteases, calcium pyrophosphate and hydroxyapatite are important pathogenetic factors in arthritis, i.e. activated osteoarthritis (2). The extent of the resulting pain and functional impairment in the mostly elderly patients often demands a rapid and efficient therapeutic action. An adequate indication provided, intraarticular administration of injectable corticosteroid preparations can afford quick relief. Although the progression of osteoarthritis will hardly be stopped, a persisting relief of pain can be achieved (13). Each intraarticular injection has to be considered a minor operation, so all its risks and possible complications have to be taken into account.

Adrenal Cortex Hormones↗
PubMed1984

[Acemetacin in the treatment of painful arthroses. Results of an open short-term study on the starting point of the analgesic effect and its duration].

Acemetacin was tested in an open clinical study with regard to occurrence and duration of its analgesic effect to 20 patients suffering from arthrosis of the hip and knee joint. The treatment lasted 3 days. The therapeutic effect was judged by the influence of pain on rest and movement. With Acemetacin the majority of the patients reported a quick onset and long duration of the analgesic effect. The tolerance of Acemetacin was very good.

Analgesia↗
PubMed1984

[Auranofin in the treatment of chronic polyarthritis. Results of an open multicenter study].

Auranofin (Ridaura SK and F 39 162) was tested in an open multicenter study with regard to its anti-inflammatory effect in 166 patients suffering from rheumatoid arthritis. The time for treatment lasted for one or two years. The therapeutic effect of the drug was judged by its influence on pain, joint swelling, morning stiffness, grip strength, blood-sedimentation rate and rheumatoid factor etc. The serum gold concentration was measured regularly. With Auranofin the majority of the patients achieved a lasting improvement of the condition. The therapeutical effect was observed gradually. Side-effects were frequent but removal from the therapy was rare. Most of the side-effects were diarrhea, rash, pruritus and conjunctivitis. Regular laboratory controls revealed in some cases toxic organic reactions.

Adolescent↗
PubMed1982

[Characteristic joint function disorders in inflammatory and degenerative rheumatism].

Inflammatory and degenerative joint diseases show a characteristic local picture. So it is recommended that a joint examination of the joint movement extent alone is not sufficient, all articular and periarticular structures must be included. In this way it is possible to differentiate on a clinical basis inflammatory and degenerative arthropathies and also to determine the stage of inflammation. Including the joint pattern, the findings of the general examination and the case history of arthropathy can be mostly diagnosed as a distinct type of rheumatism. The directed laboratory and X-ray examination confirms the diagnosis which already has been made clinically. Therefore the physical examination of the joints is of greatest importance in rheumatology.

Hand Deformities, Acquired↗
PubMed1982

[Double-blind comparative trial of lonazolac-Ca versus naproxen in spinal osteoarthrosis, coxarthrosis and gonarthrosis (author's transl)].

Two groups of patients, each consisting of 20 patients suffering from spinal osteoarthrosis, coxarthrosis or gonarthrosis participated in a double-blind comparative trial. They received either Lonazolac-Ca (200 mg three times daily) or Naproxen (250 mg twice daily plus 1 placebo capsule in between doses) for three weeks. The therapeutic response was assessed by monitoring pain intensity at rest and on exercise, joint tenderness and joint movement, muscular tension, morning stiffness and walking ability. In spinal osteoarthrosis vertebral flexibility was also measured. Nine out of 11 parameters showed significant improvement with Lonazolac-Ca, whereas only 6 out of 11 improved with Naproxen. However, no clinically relevant differences were recorded between both medications. Laboratory tests in both treatment groups revealed no changes in haematological or biochemical parameters nor in urinanalysis results. Drug-related gastro-intestinal side effects were observed in 2 patients of each treatment group. The patients on Lonazolac-Ca tolerated their medication with the aid of concomitant antacids whereas Naproxen had to be discontinued. One case of dermatitis, which was probably not drug-related was observed in each group. One patient suffering from migraine experienced vertigo and headache on taking Lonazolac-Ca; although this was probably not drug-related medication was discontinued.

Adolescent↗
PubMed1980

[Sulindac in the treatment of soft tissue rheumatism (periarthropathy of the hip and shoulder (author's transl)].

Sulindac (Clinoril) was tested in an open clinical-therapeutical study with regard to its analgesic effect and the improvement of function in 20 patients of both sexes suffering from periarthropathy of the hip or shoulder. The treatment lasted 4 weeks. The therapeutic effect was judged on the basis of the influence on the spontaneous pain and on the pain by pressure, on the functional improvement and on the daily habits of the patients. It was noted, that there was a lasting improvement due to the analgesic effect already in the first week of therapy and an improvement of function in the second week of therapy in the majority of the cases. Sulindac was well tolerated. Laboratory findings in the beginning and at the end of the four weeks treatment period revealed no toxic effects on organs, particularly on hematopoietic system.

Adult↗
PubMed1978

[Long-term comparative study: diclofenac (voltaren) and naproxen (proxen) in arthritis].

Two non-steroidal antirheumatic drugs, diclofenac (Voltaren) and naproxen (Proxen), were compared with respect to their analgesic effect and the observed improvement in joint mobility in two groups of patients, each consisting of 20 males with either cox-arthrosis or gonarthrosis. The duration of treatment was up to six months. The therapeutic response was assessed by the mean scores of spontaneous and exercise-induced pain, the clinical state of joints and painfree time of walking. Both drugs led to a persistent improvement in the condition of most patients, but the clinical impression would appear to point to a more marked analgesic effect of diclofenac. The daily maintenance dosage from the fourth week of treatment onwards was 75 mg diclofenac and 500 mg naproxen. Both drugs were generally well tolerated. Occasionally gastrointestinal side effects were observed (more frequently in the naproxen group). Laboratory controls were carried out periodically, but no evidence of organ toxicity or hemotoxic effects was found.

Arthritis↗
PubMed1978

A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.

In this controlled, single-blind parallel group study, the effect of ibuprofen 1200 mg daily was compared with diclofenac 75 mg daily. Thirty patients entered the study, randomized into two groups, each group receiving one tablet three times daily for two weeks. A one-week wash-out period (i.e. a drug-free period during which only physiotherapy was given), preceded and followed the treatment on active drug. Assessments were made by the same clinician throughout who was unaware of the treatment of individual patients. Statistically significant improvement was shown by patients receiving ibuprofen for the degree of pain relief at rest and improvement was also shown for the degree of pain at rest and during exercise, for pain relief during exercise and for spinal flexion. Patients who received diclofenac showed statistically significant improvement for forward flexion, together with improvement for the degree of pain on exercise. Side-effects were very few.

Adult↗
PubMed1977

A comparative study of flurbiprofen and indomethacin in rheumatoid arthritis.

A double-blind crossover trial of 200 mg flurbiprofen daily and 100 mg indomethacin daily, each given for 2 weeks separated by a 1-week placebo washout period, was carried out in 30 patients with rheumatoid arthritis. The results were analyzed for the 26 patients with complete records. No statistically significant differences were found between the two treatments with regard to subjective impression of pain severity, duration of morning stiffness, grip strength, joint size, haemoglobin and erythrocyte sedimentation rate. When the results for each treatment period were compared to baseline and both drugs considered individually, there was a statistically significant improvement from baseline. During the flurbiprofen treatment period the erythrocyte sedimentation rate showed a statistically significant fall, but not with indomethacin. During the placebo washout period between the active therapies, there was a statistically significant worsening in all parameters apart from the level of haemoglobin and erythrocyte sedimentation rate. These assessments showed little change. Five patients reported side-effects with indomethacin, and 1 with flurbiprofen. No side-effects were reported during the placebo period and although 4 patients were withdrawn, none was withdrawn because of side-effects. Patient preference was for flurbiprofen.

Aged↗
PubMed1976

[Double-blind trial: ketoprofen versus phenylbutazone in acute gouty arthritis (author's transl)].

A double-blind study was carried out to compare the effects of ketoprofen and phenylbutazone in acute gouty arthritis. Two groups of patients, each consisting of 23 males, received intramuscular injections of either phenylbutazone (2 X 300 mg daily) or ketoprofen (2 X 50 mg daily) for a period of 7 days. The drug effects were assessed both subjectively and objectively. There was an excellent therapeutic effect in both groups. In general, no statistically-significant differences were detected between the two preparations. However, ketoprofen appears to be slightly better tolerated with respect to the incidence of systemic and local side effects. Thus, the administration of ketoprofen can be recommended in cases of acute gouty arthritis.

Acute Disease↗
PubMed1976

[Extra-articular manifestations of chronic polyarthritis].

Although the chronic destructive joint processes dominate the clinical picture of chronic rheumatoid arthritis, it must not been forgotten that the disease is a systemic one, whereby certain organs or organ systems are affected either clinically or subclinically. The various possible pathogenetic mechanisms are discussed and the particular type of patient with rheumatoid arthritis who appears to be prone to extra-articular manifestations is described. Subsequently, the individual organic manifestations and the clinical picture are discussed, as well as the incidence and significance of these features.

Amyloidosis↗
PubMed1976

[Scintigraphic demonstration of the synovial membrane].

A new technique to diagnose and control the progress of pcp in the hand is described using Tc 99 m to visualize inflammatory reactions in various tissues. Objectivity, repeatability and the possibility to see the disease in its earliest stages are advantages of the method.

Arthritis, Rheumatoid↗
PubMed1975

[Generalized secondary amyloidosis in patients with chronic rheumatoid arthritis (author's transl)].

During a period of 6 years (1968 to 1973) 177 patients with rheumatoid arthritis were submitted on one or more occasions to biopsy of the rectal mucosa for the diagnosis of amyloidosis. The indications for biopsy were as follows: 1. proteinuria, even in an intermittent form, 2. progressive type of rheumatoid arthritis with high inflammatory activity, 3. rheumatoid arthritis of longer than 2 years duration with a marked tendency to joint destruction. The histological specimens were stained with Congo red and investigated in polarized light. The biopsy for amyloidosis was positive in 80 patients (45.2%) of whom 14 showed no proteinuria, even of an intermittent nature. Patients with rheumatoid arthritis survived maximally 5 years after amyloidosis had been diagnosed. No successful therapy of amyloidosis has been devised.

Adult↗
PubMed1975

[Complications in chloroquin therapy].

Chloroquine and hydroxychloroquine are widely used in diseases of connective tissue, especially in rheumatoid arthritis and systemic lupus erythematosus. However, various side effects are reported in many publications. In general these side effects are less important, e.g. those on the gastrointestinal tract and drug exanthema. Disorders of the haemopoetic system, the central nervous system, and peripheral neuromyopathy are rare. Only few reports exist about fetal damage. In contrary, severe problems result from eye complications such as reversible keratopathy and mostly irreversible retinopathy. If, however, chloroquine is administered, the necessity of exakt dosage and periodic ophthalmologic controls has to be stressed.

Arthritis↗