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Biomedical subjects

W Schulte

Publications and source records attributed to W Schulte.

At least 73 records · Page 4Linked to original sources
PubMed1987

Psychophysiologic aspects in essential hypertension.

Epidemiologic and experimental studies disclosed that the sympathetic nervous system might play a pivotal role in the pathogenesis of essential hypertension. Although systolic pressure exhibits a weak endogenous rhythm, diurnal fluctuations of arterial pressure are provoked primarily by physical or emotional stress factors. The magnitude of the cardiovascular response, however, varies widely from individual to individual. Subjects at high risk of future hypertension,--such as those with a positive history of familial hypertension, high resting heart rate, or transient increase in arterial hypertension--revealed blood pressure hyperresponsiveness to stress stimuli mediated by an overreactivity of the sympathetic nervous system. Furthermore, cardiovascular reactivity to mental arithmetic tasks and to traffic noise put a patient at high risk of developing arterial hypertension. In women, exaggerated cardiovascular response to stress stimuli appeared to be mitigated by estrogens, whereas oral contraceptives overrode this 'protective' effect of estrogens. At a certain point, repeated episodes of high stress blood pressure could produce structural vascular changes finally inducing sustained hypertension.

Arousal↗
PubMed1986

Hemodynamic abnormalities in borderline hypertension during mental stress.

Cardiovascular reactivity to mental stress was studied in 41 male borderline hypertensives in comparison with 37 male normotensives of the same age. In addition to a higher near-basal blood pressure, the borderline hypertensive group showed stronger absolute and percentage increases of systolic and diastolic blood pressure during stress. The increases of heart rate and cardiac output and the decreases of total peripheral resistance were also greater in borderline hypertensives. Stroke volume showed a slight increase only in this group. The reaction of mean arterial pressure correlated in both groups with the increase of cardiac output. The relationship between the reactions of cardiac output and total peripheral resistance was high both in normotensives and borderline hypertensives, and the regression line in normotensives was shifted to the right in borderline hypertensives. The results indicate an increased integrated change of circulatory parameters during mental stress in borderline hypertension, with a dominantly stronger cardiac reaction. They underline the significance of an autonomic imbalance for the pathogenesis of borderline hypertension.

Adult↗
PubMed1985

Long-term ambulatory treatment of metastatic colorectal adenocarcinoma by continuous intravenous infusion of 5-fluorouracil.

To delineate the efficacy of continuous intravenous 5-fluorouracil (5-FU) infusion therapy for advanced colorectal adenocarcinoma, a study of 36 patients with measurable metastatic disease was conducted. Patients received a daily intravenous infusion of 300 mg/m2 5-FU over a 24-h period utilizing portable infusion devices and central venous catheters. In a population characterized by substantial pretreatment exposure to radiotherapy, chemotherapy, and other indicators of poor prognosis, 13/36 (36%) patients achieved an objective response. An additional 10/36 (28%) patients manifested stable disease (no change) and experienced survival comparable to that of patients with objective response. Toxicity was minimal; patients were able to continue 5-FU infusions 95% of the total time on protocol. There were no adverse hematologic effects or catheter complications. Because previously untreated patients benefited more frequently (positive response, 50%), continuous intravenous infusion should be evaluated further as a primary modality option when 5-fluorouracil antitumor chemotherapy is contemplated.

Adenocarcinoma↗