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Biomedical subjects

W Schubert

Publications and source records attributed to W Schubert.

At least 73 records · Page 4Linked to original sources
PubMed1990

[Malignant tumors of the lung and bronchi in children and adolescents. 2. Analysis of 66 cases of the East German National Cancer Registry (1961-1985)].

In the National Cancer Registry of the GDR from 1961 to 1985 only 66 cases malignant (and semimalignant) tumors of the bronchi and lung in patients under 20 years of age were collected. These amounted to 0,037 per cent of all tumor cases of this localization. These tumors affected 37 boys and 29 girls. Tumors of mesenchymal origin prevailed (32 cases = 48.4 per cent) in comparison to those of epithelial (37.8 per cent) and embryonal origin (10.7 per cent). Among these cases were 10 bronchial carcinomas and 10 bronchial adenomas. 51.5 per cent of all patients died in the clinic. Less than half of the patients were due to adequate therapy discharged free of any tumor. Data about the late prognosis of these patients were not available.

Adolescent↗
PubMed1989

Lymphocyte antigen Leu-19 as a molecular marker of regeneration in human skeletal muscle.

Antigen Leu-19 (Leu19-Ag), a 200- to 220-kDa surface glycoprotein, was originally identified on a subset of human peripheral lymphocytes exhibiting non-major histocompatibility complex-restricted cytotoxicity. Here we report that monoclonal antibody Leu-19 (mAb-Leu19) labels structures in human skeletal muscle: (i) satellite cells, which form the stem cell pool of muscle fiber regeneration, both in normal and diseased muscle; (ii) myotubes and myotube projections in regions of muscle fiber repair; (iii) periodically organized fibrillar structures in areas of regeneration; (iv) the surface of myoblasts and developing myotubes in culture. mAb-Leu19 precipitated a protein of approximately 200 kDa from cultured muscle cells. Our data show that Leu19-Ag is expressed on muscle-specific components of myosegments in repair and thus represents a molecular marker of muscle regeneration. On the basis of this molecular marker and using laser scan microscopy, it is possible to visualize at the light microscopic level hitherto undetectable details of muscle regeneration in routine cryostat sections.

Antigens, Differentiation, T-Lymphocyte↗
PubMed1989

Composite in situ vein bypass for upper extremity revascularization.

Chronic upper extremity arterial insufficiency is rare. Consequently, major reports specifically limited to the topic are scarce, and the clinical experience is small. In addition, symptomatology, diagnostic criteria, and guidelines for surgical management remain ill-defined. In the lower extremities, however, in situ vein bypass has been attempted for nearly three decades. This technique offers many advantages over traditional revascularization methods. Although the procedure has become popular for the lower extremity, no report of its use in the upper extremity is found in the literature. We report what may be the first case in which in situ bypass was used in the upper extremity for a threatened limb secondary to diabetic occlusive vascular disease complicated by a previous shunt used for hemodialysis. Revascularization of the upper extremity using the in situ vein bypass technique may offer a new alternative to traditional methods of revascularization.

Adult↗
PubMed1989

[Malignant tumors of lungs and bronchi in children and youths. 1. Compilation of 175 cases from the literature].

The authors collected data of 175 malignant and semimalignant tumors in children and adolescents. 74.3 per cent of all reported cases were epithelial tumors (44.0 per cent bronchial adenomas and 30.3 per cent carcinomas), 15.4 per cent of embryonal and 10.3 per cent of mesenchymal origin. All age groups were affected. In children under one year of age embryonal tumors prevailed, in preschool age carcinomas and embryonal tumors dominated while in schoolchildren more often bronchial adenomas and carcinomas were found. All these tumors are very unusual in the pediatric age group. Therefore the right diagnosis is often missed for a longer time.

Adolescent↗
PubMed1988

Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle.

Cloning and sequence analysis revealed the putative amyloid A4 precursor (pre-A4) of Alzheimer's disease to have characteristics of a membrane-spanning glycoprotein. In addition to brain, pre-A4 mRNA was found in adult human muscle and other tissues. We demonstrate by in situ hybridization that pre-A4 mRNA is present in adult human muscle, in cultured human myoblasts and myotubes. Immunofluorescence with antipeptide antibodies shows the putative pre-A4 protein to be expressed in adult human muscle and associated with some but not all nuclear envelopes. Despite high levels of a single 3.5-kb pre-A4 mRNA species in cultured myoblasts and myotubes, the presence of putative pre-A4 protein could not be detected by immunofluorescence. This suggests that putative pre-A4 protein is stabilized and therefore functioning in the innervated muscle tissue but not in developing, i.e. non-innervated cultured muscle cells. The selective localization of the protein on distinct nuclear envelopes could reflect an interaction with motor endplates.

Adult↗
PubMed1988

Use of the labial artery for replantation of the lip and chin.

A 12-year-old boy suffered from a full-thickness traumatic amputation of his lower lip and chin following a horse bite. Microsurgical technique was used to reanastomose the inferior labial artery and a vein of the chin. The replanted flap remained viable, and the patient has done well despite some early problems with eating and drooling. The patient is now able to purse his lips and has regained sensation and the use of his orbicularis oris and musculus mentalis, even though no attempt was made to repair the motor nerves or sensory nerves. Because of the potential superior cosmetic and functional results following replantation, we recommend aggressive microsurgical attempts at arterial and venous anastomosis not previously described following traumatic amputation. The inferior labial artery may be considered for use as a nutrient artery for replantation and in future elective maxillofacial reconstruction and free-flap transfer.

Amputation, Traumatic↗
PubMed1988

Fat-soluble 17 beta-estradiol: a way of reducing dosage in steroid hormonal substitution?

Eight ovariectomized women were given 0.5 mg 17 beta-estradiol cyclo-octyl acetate (E2COA) dissolved in arachis oil + 0.15 mg desogestrel, and 2 mg micronized 17 beta-estradiol (mE2) + 0.15 mg desogestrel orally in a crossover fashion for 20 days each. The preparations were taken on 10 days together with a meal, on 10 days 3 hours after a meal. Blood samplings were performed 3 h after capsule ingestion for analysis of serum estradiol (S-E2), estrone (S-E1) and sex hormone binding globulin (SHBG). Before treatment, all women had climacteric complaints. During treatment these symptoms were alleviated and no discomfort was reported. No differences in serum levels of estrogens were found in either of the preparations when capsules were taken with or without food. However, serum levels of E2 were found to be 100% higher per mg substance given after E2COA vis-à-vis mE2. This indicates either a delayed breakdown and/or a better resorption. The E1/E2 ratio after E2COA was only half that after mE2 intake. This hints at another route of resorption. SHBG concentrations were somewhat elevated following mE2 administration, whereas a slight decrease was found after E2COA. The resulting post-treatment difference was significant, suggesting a less estrogenic liver effect by E2COA. No accumulation of E2 or E1 was seen after either of the preparations. Our findings support the hypothesis that E2COA, being fat soluble, is resorbed via the lymphatic system. By avoiding the first liver pass the dosage of estrogen can be halved.

Aged↗
PubMed1988

Creatine kinase as a prognostic indicator in electrical injury.

Serial serum creatine kinase (CK) and creatine kinase myocardial band isoenzyme (CK-MB) levels were obtained from 116 of 125 electrical burn patients admitted from 1976 through 1986. We divided patients into three groups (peak CK within 2 days after admission) as follows: group 1, CK less than 400 U/L; group 2, CK = 400 to 2500 U/L; group 3, CK greater than 2500 U/L. Clinical myocardial infarction (MI) was determined by ischemic ECG changes, LDH isoenzyme patterns, and clinical course. Skin grafts occurred in 2 of 24 patients from group 1, in 15 of 31 from group 2, and in 37 of 61 from group 3. Hospital stay (mean +/- SEM) was 4.6 +/- 1.3 days for group 1, 20.2 +/- 5.4 for group 2, and 37.7 +/- 3.6 for group 3. Group 1 patients required no amputations; group 2 had 1 limb and 5 digit amputations; group 3 had 22 limb and 16 digit amputations. Only three clinical MIs were found (all in group 3), although 1 of 31 patients from group 2 and 32 of 61 from group 3 had CK-MB greater than 4%. Highly elevated CK and CK-MB are associated with longer hospitalization, and a greater risk of skin grafting or amputation, than with levels less than 400 U/L. Clinical MI is rare and cannot be diagnosed by elevated CK-MB alone.

Adolescent↗
PubMed1988

[Replacement esophagoplasty by the jejunum].

The authors discuss the problem of oesophagus replacement in children with congenital Type Vogt II atresia. They describe their own experience obtained from replacement, using jejunum.

Child, Preschool↗
PubMed1988

[Complications of shunt drainage in pediatric hydrocephalus].

The most frequently occurring complications of the atrial and peritoneal drainage for the treatment of the hydrocephalus are represented and some rare causes of revision are described. Then follows a list of the more frequently occurring shunt incidents in the valve implantations carried out at our hospital in the period from 1963 to 1986. A total of 387 drainage operations are analysed, including 155 ventriculo-atrial and 232 ventriculo-peritoneal drainages. Then follows a description of the course of the therapy of three patients in whom relatively rare complications were observed. In view of the significantly lower sepsis incidence of 8.2 per cent as compared to 16.1 per cent in the atrial drainage, the peritoneal drainage proved to be superior to the latter. The consideration of the Cordis-Hakim- and Spitz-Holter-systems frequently used at present showed no essential differences of the respective results of the treatments. Our experience gained in the treatment of the hydrocephalus are discussed in comparison with the international statements.

Adolescent↗
PubMed1988

[Intraoperative measurement of velocity and volume of coronary circulation using the Duplex system].

A high frequency ultrasound system processor was used for an intraoperative evaluation of coronary blood flow velocity and volume. In 12 patients with symptomatic coronary heart disease, morphology and hemodynamic parameters of the coronary artery system were examined intraoperatively. Optimal imaging was possible by keeping the ultrasound transducer at a constant distance of a few millimeters from the surface of the heart and the pericardial space between them filled with saline solution. Using this technique, large areas of the cardiovascular system were reproducible up to a peripheral vascular diameter of 2-3 mm. Blood flow velocity (20 to 33 cm/s) and blood volumes (33 to 94 ml/min) provide quantitative information on the degree of stenosis intraoperatively after coronary anastomosis during bypass surgery. All images were of outstanding quality and precision. This method is highly valuable for the intraoperative determination of blood flow parameters.

Adult↗
PubMed1988

Scalping injuries: new technique for stabilization of flaps to the skull.

Extensive scalping injuries offer a unique challenge for tissue coverage because of the wide expanse of bone and lack of deep soft tissue or significant perforating vessels. For smaller injuries, pedicle flaps offer ideal coverage. Larger defects can be covered by omental flaps. Coverage with a free muscle flap followed by split-thickness skin grafting offers optimal long-term coverage. Two new techniques are introduced. The wire-button technique offers stabilization, and the halo frame provides good support and protection for a new free-flap graft and may increase the success rate of flaps in patients with scalping injuries.

Humans↗