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Biomedical subjects

W Schranz

Publications and source records attributed to W Schranz.

17 recordsLinked to original sources

[Spectrum of indications for flexible bronchoscopy. Importance in a general hospital].

Fiberbronchoscopy is an extremely safe procedure carrying only minimal risk to the patient. Diagnostic application may include a transbronchial biopsy, brushing, and bronchoalveolar lavage. The indications for therapeutic bronchoscopy are, in particular, targeted irrigation and aspiration, extraction of foreign bodies, and hemostasis. Diagnostic and therapeutic indications are demonstrated in a number of cases.

Biopsy

The nonspecific clearance function of the reticuloendothelial system in patients with immune complex mediated diseases before and after therapeutic plasmapheresis.

The nonspecific clearance function of the reticuloendothelial system (RES) in six patients with immune complex mediated systemic vasculitis was determined by the evaluation of the disappearance rate of technetium 99m labelled microaggregated human serum albumin colloid (MHAC) injected IV before and after therapeutic plasma exchange. Three patients with systemic lupus erythematosus (SLE) and one patient with immune complex vasculitis (ICV) exhibited a significant clinical improvement after plasmapheresis which was paralleled by an accelerated MHAC elimination rate following plasma exchange therapy. One patient with ICV and unresponsive to plasma exchange showed delayed MHAC elimination. In one patient with myasthenia gravis (MG), the elimination rate was not altered by plasmapheresis. The data obtained indicate that nonspecific clearance of the RES may be one effect of plasma exchange therapy in patients with immune complex mediated diseases.

Adolescent

[Treatment of immunologic diseases using plasma separation. Proven and unproved indications].

By experienced specialists plasma separation can be applied without any serious complications. It can be expected that in future specific principles of plasmapheresis for the elimination of pathogenetic agents will be developed. Even if the exact mechanism of action of this therapeutical principle is is not yet known in all details, plasma separation is indicated as a therapeutic emergency measure in patients with autoaggressive diseases especially in case the patient is endangered by marked progression of the disease and by the failure of conservative therapy with immunosuppressive agents. So far we have treated 48 patients with 206 plasma exchanges, most ot them because of immune diseases such as systemic lupus erythematodes and immunvascultits .

Adult

[Myelosarcoma--an unusual heart tumor. Differential diagnosis of hypertrophic and non-obstructive cardiomyopathy].

Heart tumours are seldom; secondary malignant tumours occur more often than primary heart tumours and there are no characteristic symptoms. According to the location and extent, tumours of the heart can cause practically all the known cardiological symptoms, not only in the discrete, but also in the dramatic form. Frequent symptoms are disrhythmia , myocardial insufficiency and pericardial effusion. In the case of uncertain cardial symptoms a possibly malignant heart disease should be looked for by means of ultrasonics, computer tomography, myocardszintigraphy and if necessary angiocardiography. If a diagnosis is made in time, the patient can be helped either by surgery, or in cases of secondary, malignant infiltrations the patient can often be treated successfully with chemotherapy or radiation. In cases of unusual heart tumours ( myelosarcoma ) this differential diagnosis should also be taken into consideration.

Cardiomyopathy, Dilated

[Syncope attack].

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Cerebrovascular Disorders

[Chest pain: differential diagnosis in general practice].

In patients with chest pain somatic pain (thoracic wall pain) has to be differentiated from visceral pain (organ pain). History and careful physical examination are diagnostic in most cases. Presented are rare and not well-known diseases like valvular aortic stenosis, idiopathic hypertrophic subaortic stenosis and the mitral valve prolapse syndrome. Not seldom they are masked by angina pectoris-like symptoms, although in general the coronary arteries are normal. In acute chest pain differential diagnostic considerations have to include lung embolism, acute pericarditis, spontaneous pneumothorax, acute dissecting aneurysm of the aorta and diseases of the gastrointestinal tract as well. Only after exclusion of any organic cause the diagnosis of "effort syndrome" may be made.

Aortic Stenosis, Subvalvular

[Benzylpenicillin-induced leucopenia in subacute bacterial endocarditis (author's transl)].

In the high-dose benzylpenicillin treatment of subacute bacterial endocarditis leucopenia can develop in rare cases. Often it is paralleled by anemia, sometimes also by a decrease in the number of platelets. Myalgia, gastric discomfort, or a sore threat deserve interest as premonitory symptoms. In every case this treatment inevitably needs through hematologic control.

Adult

[Bone marrow depression with peripheral pancytopenia under the treatment with an ampicillin/oxacillin combination (author's transl)].

Under the treatment with ampicillin or oxacillin resp. hematologic changes turn up very rarely except for eosinophilia, in addition it is only granulocytes or platelets alone which are involved in the cases yet published. In the case presented here therapy by an ampicillin/Oxacillin combination induces bone marrow depression with peripheral pancytopenia on a toxic or allergic base.

Adult