Search PubMed⌕ Search

Biomedical subjects

W Schmidt

Publications and source records attributed to W Schmidt.

At least 757 records · Page 42Linked to original sources
PubMed1976

Elimination of vasopressin by the normal and the damaged liver. Experiments on unanaesthetized normal and thiocetamide treated rats with a note on the influence of ethanol.

Arginine vasopressin was infused into the V. portae and into the V. cava of unanesthetized rats in water diuresis. The differential antidiuretic response of the same animal to these infusions was used to calculate extraction fraction of ADH by the liver. In the normal rat no extraction was detected. The liver of rats hydrated with 5% ethanol extracted 10% and that of rats treated with thioacetamide extracted 60% of the ADH infused into the portal vein. It is postulated that disturbances of liver cell function by narcotics and substances causing liver damage may liberate ADH-destroying ferments into the blood.

Acetamides↗
PubMed1976

Purification and characterization of tRNAMet-f, tRNAPhe and tRNATyr2 from Baccillus subtilis.

Three tRNAs specific for methionine, phenylalanine and tyrosine were isolated from the total tRNA of Bacillus subtilis by chromatographic procedures using BD-cellulose and reversed-phase (5) chromatography. The acceptor activities of the purified tRNAs are 1160, 1260 and 1320 pmoles per A260nm unit for tRNAMetf, tRNAPhe and tRNATyr2 respectively. In tRNAMetf and tRNAPhe ribothymidine, pseudouridine and dihydrouridine are present, in addition, in tRNAPhe 7-methyguanosine and a 2'-O-methylated nucleoside were found. The modified nucleosides of tRNATyr2 are ribothymidine, pseudouridine, dihydrouridine, 4-thiouridine and 1-methyladenosine. The results suggest the presence of 2-methylthio-N6(delta 2-isopentenyl)adenosine in tRNAPhe and tRNATyr2. The thermal denaturation profiles of the three tRAN species are presented.

Bacillus subtilis↗
PubMed1976

[Pulmonary gas exchange after myocardial infarction in the late period of recovery. I. Investigation at rest].

In the late period of recovery after myocardial infarction (13-25 months p. infarctum) lung function of 23 patients was examined at rest. Spirometric values and parameters of pulmonary gas exchange showed alterations caused by pathological left ventricular function. Arterial Po2 was slightly decreased (chi=74.5 +/- 5.9 Torr), AaDo2 (chi=33.6 +/- 7.7 Torr) and aADco2 (chi=8.6 +/- 3.7 Torr) were increased. Pathological changes of arterial Pco2 (chi=40.6 +/- 2.5 Torr) were not observed. Mixed venous Po2 and cardiac output in 9 patients suggested cardiac failure. In a number of pulmonary parameters measured at rest correlations could prove a dependence on the patients physical work capacity.

Carbon Dioxide↗
PubMed1976

[Pulmonary gas exchange after myocardial infarction in the late period of recovery. II. Investigations during exercise (author's transl)].

After myocardial infarction in the late period of recovery (13-25 months p. infarctum) pulmonary gas exchange in 23 patients was measured besides as hemodynamic parameters during exercise. The parameters take a course similar to that of subjects without lung and heart diseases. Arterial blood gas tensions (Pa02, Paco2) remain unchanged compared to resting values. Alveolar ventilation did show no difference in any of the patients. Minute ventilation VE, the various dead spaces, alveolar-arterial gas differences (AaDo2, aADco2) and ventilation-perfusion ratios of the whole lung VA/Q suggest however that these parameters show different courses according to the physical capacity of the patients. As the physical capacity of each patient is due to different cardiac functions taken by cardiac output and mixed venous blood gas tensions alterations of pulmonary gas exchange seemed to be dependent on the respective left ventricular function of the heart. Of the twenty-three patients, twelve with cardiac failure under exercise showed the most pronounced alterations in pulmonary gas exchange. Therefore, the different physical work capacity of the patients are determined only by cardiac function. No limitation of the productivity due to impeded lung function could be proved.

Carbon Dioxide↗
PubMed1976

Social class and morbidity in clinically treated alcoholics.

The lifetime physical disease profiles of 122 lower and 724 middle class non-skid row alcoholics admitted to an inpatient treatment facility were compared to further clarify the significance of social class as a determinant of morbidity in alcoholics. The overall severity of physical disease and the frequency of all recorded lifetime illness diagnoses were greater in the lower than in the middle class. The former experienced more trauma, genitourinary disorders, venereal disease and malnutrition, as well as small excesses of respiratory and nervous system disorders. There were no class differences in the lifetime frequencies of liver and biliary tract, gastrointestinal, cardiovascular, endocrine and metabolic, integumentary, locomotor and haemopoietic disorders, or in the incidences of a number of disease entities including acute brain syndromes and chronic brain damage. The drinking patterns of the classes were similar, but the average duration of hazardous drinking was longer and the average current consumption was greater in the lower class. There were no class differences, however, in the average duration of hazardous drinking before the first occurrence of certain diseases. The referral sources of the classes were significantly different. Possible explanations for the differences between the findings of this and earlier studies are discussed.

Adult↗
PubMed1976

Partitioning of the alveolar-arterial O2 pressure difference under normal, hypoxic and hyperoxic conditions.

The alveolar-arterial O2 pressure difference (AaDO2) is composed of three parts which depend on inhomogeneities of the ventilation-perfusion ratio (AaD(distr.) 1), on size and distribution of the diffusing capacity-perfusion ratio (AaD(distr.) 2), and on the effect of the shunt perfusion (AaD(sh)). These three parts can be calculated for normal, hypoxic and hyperoxic breathing conditions if the inhomogeneities of the function parameters and the size of the shunt perfusion are known. The calculation based on experimental data in 28 healthy subjects shows the following results: (1) Under hypoxic breathing conditions the AaD(distr.) 2 due to diffusion dominates. However, even at alveolar O2 pressures below 45 mm Hg the AaD(distr.) 1 must not be ignored. (2) Under normal breathing conditions AaD(distr.) 2 may be ignored and will under pathological conditions become relevant only if the diffusing capacity-perfusion ratio is below 3.10(-3) mm Hg(-1). (3) Under hyperoxic breathing conditions the AaD(sh) is predominant. However, even with the inhalation of pure oxygen, the AaD(distr.) 1 contributes 10% of the total AaDO2. (4) When evaluating the methods of measurement of the O2 diffusing capacity and of the shunt perfusion the inhomogeneities of ventilation, perfusion and diffusion must be considered.

Humans↗
PubMed1976

Some factors affecting the likelihood of moderate drinking by treated alcoholics.

The 1-year outcome in alcoholics who participated in an outpatient alcoholism treatment program which stressed moderate drinking as the ultimate treatment goal was investigated. The results suggest that such an approach, in an otherwise conventional treatment program, is likely to result in a higher rate of moderate drinking and a lower rate of abstinence but not in a higher over-all recovery rate than a total-abstinence orientation.

Alcohol Drinking↗
PubMed1976

Impressions of Jewish alcoholics.

Jews, constituting 6% of the adult population in Toronto, contributed 0.5% of all admissions to one private and one public clinic for alcoholism during a 10-year period. Their demographic, sociocultural and psychological characteristics, and several modes of adjustment to being Jewish alcoholics, are described.

Adult↗