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Biomedical subjects

W Schmidt

Publications and source records attributed to W Schmidt.

At least 649 records · Page 36Linked to original sources
PubMed1981

[Diagnosis of siamese twins at 12 weeks gestation (author's transl)].

Double monsters are a rare obstetric event. The mean incidence is approximately 1:50,000 deliveries. The early diagnosis of siamese twins with the aid of routine ultra-sound investigation is described. Typical ultrasound findings and procedures to verify the diagnosis are described in detail.

Abortion, Induced↗
PubMed1981

Effects of crude and purified human chorionic gonadotropin on lymphocyte response.

Human chorionic gonadotropin (hCG) preparations with different biological activities were tested for their inhibitory effects on mitogenic of allogenic induced lymphocyte response. Various crude hormone batches inhibited the lymphocyte reaction in a dose-dependent manner. However, we found a varying suppression of lymphocyte response not correlated to the biological activity (2,660-4,300 IU/mg) of crude hormone. Fractions with very low gonadotropic activity (much less than 500 IU/mg) showed a 100-fold inhibition of lymphocyte reaction. Conversely, the enrichment of highly purified hCG with strong biological activity (greater than 10,000 IU/mg) had no inhibitory effect on mitogenic or allogenic induced lymphocyte transformation. Isoelectrofocussing and immunoelectrophoretic investigations indicated that the inhibition is probably caused by nondialyzable sialoglycoproteins. It is therefore very doubtful whether hCG plays an important part in maternal tolerance of the fetal allograft.

Chorionic Gonadotropin↗
PubMed1981

Primary oxalosis with pan-conduction cardiac disease: electrophysiologic and anatomic correlation.

A 27-year-old man with primary oxalosis and extensive visceral involvement was maintained on long-term chronic hemodialysis. He had an episode of presyncope associated with electrocardiographic findings of an erratic atrial rhythm, atrioventricular dissociation due to an accelerated junctional rhythm and right bundle branch block. Electrophysiologic studies showed irregular atrial depolarizations probably associated with multiple atrial pacemakers, atrial inexcitability, atrioventricular dissociation and infranodal conduction delay. These findings correlated well with extensive oxalate infiltration of the sinoatrial node and its approaches, the atrial preferential pathways, the approaches to the atrioventricular node, the atrioventricular node, and the His bundle and bundle branches. This is the first reported case of cardiac electrophysiologic abnormalities due to oxalate infiltration in a patient with primary oxalosis.

Adult↗
PubMed1981

Morbidity patterns in hazardous drinkers: relevance of demographic, sociologic, drinking, and drug use characteristics.

A profile of the demographic, sociologic, drug use, and drinking characteristics of a large group of inpatient alcoholics has been constructed as background for discussion of the clinical significance of these factors as determinants of physical morbidity in hazardous drinkers. Factors specifically considered include sex, skid row status, social class, and abnormal use of drugs of dependence, the amount of alcohol consumed and duration of drinking, drinking pattern, and type of beverage. While heavy drinking is of primary importance, the physical disease profile found in hazardous drinkers is modified by certain host and environmental characteristics. The implications for treatment planning and preventive programs are considered.

Adolescent↗
PubMed1981

[Prenatal differential diagnosis in elevated alpha-fetoprotein concentration in the amniotic fluid (author's transl)].

Elevated Alpha-Fetoprotein (AFP) values in the amniotic fluid are most frequently associated with neural occlusive disturbances or, in rare cases, with other external malformations of the foetus. In this article, the authors report on two cases where the elevated AFP had not been due to fetal malformations. In the first case, the cause was identified as foetal proteinuria, probably in the sense of an autosomal-recessive hereditary congenital nephrosis, whereas in the second case the phenomenon was possibly due to a "foetal distress" syndrome. Attention is drawn to the importance of elevated AFP levels. The possibilities of further prenatal differential diagnosis are discussed, such as ultrasound, determination of acetyl cholinesterase AChE) activity and assessment of the amniotic fluid cells.

Abnormalities, Multiple↗
PubMed1981

[Prenatal diagnosis of Meckel-Gruber's syndrome by ultrasound (author's transl(].

The article reports on the ultrasonographic diagnosis of a Meckel-Gruber's syndrome in the 17th week of pregnancy. This malformation syndrome is characterized by the triad: encephalocele, polycystic kidneys, and polydactyly. This congenital disease is compared with malformation syndromes which are distinguishable by differential diagnosis, such as Potter's renofacial syndrome. Thorough ultrasonic examination will be able to detect the severe renal changes as well as the neural tube defects associated with Meckel-Gruber's syndrome. Further diagnostic aids for detecting neural tube defects are, in the first place, the alpha-fetoprotein values obtained from the serum of the mother and/or the amniotic fluid, as well as the determination of acetyl cholinesterase.

Adult↗
PubMed1981

[Ultrasonographic diagnosis of a combined malformation syndrome - hydrocephalus - evisceration and dysplasia of the extremities (author's transl)].

The article reports on the ultrasonographic criteria in a complex malformation syndrome (hydrocephalus, evisceration and phocomelia of the lower extremities). Additional examination methods which are suggested whenever there is a suspicion of foetal malformation, are described. The majority of severe congenital malformations can be discovered antenatally via thorough sonographic examination of the foetus in the longitudinal and transverse axes.

Abnormalities, Multiple↗
PubMed1981

[Determinations of immunoglobulin from the blood of the umbilical vein after pathological course of pregnancy and in foetal growth retardation (author's transl)].

Serum-IgM and serum-IgA concentrations of 561 unselected samples of umbilical cord were determined by the radial immunodiffusion method (Mancini's technique). The mean IgM value of all blood samples was 13.8 mg%. In 9.9% of all cases only we found measurable IgA values, the average IgA concentration being 4.5 mg%. Elevated IgM values (greater than 30 mg%) - pointing to an intrauterine infection - were found to be more frequent (12.1%) in foetal of growth retardation than with newborn of normal body weight, where the incidence of increased IgM values was 5.5% of the examined cases only (however, without a statistically significant difference). In preceding infections during pregnancy, elevated IgM values (greater than 30 mg%) were also found more frequently than in cases without infections (11.8% vs. 5.7%, respectively). Basing on these results, we can suspect that intrauterine infection is one of the possible causes of foetal growth retardation, but not one of the main ones.

Adult↗
PubMed1981

[Sonographic biometry of the fetus-crown-rump-length in the first half of pregnancy].

In 268 pregnant women with known duration of pregnancy the crown-rump-length of the fetus was measured by means of a real-time-scanner. For the period between week 7 + 0 to 20 + 0 normal curves are established. In addition the mean daily incremental rate is given. A maximum increment of 1,9 mm/day was found between week 12 + 0 and 13 + 0. The optimal date for the estimation of the gestational age is the early period between week 7 + 0 an 14 + 0. In this period the 96% confidential range (+/- 2 SD is +/- 7 days. To the end of the first half of pregnancy the precision of the estimation (+/- 2 SD) becomes worse (+/- 10 days). The fetal crown-rump-length could be measured in all cases from up week 7 + 0. Here we see a definite advantage of the real-time-scan-technic-in spite of a diminished precision of measuring - vs the compound-scan-technic.U

Female↗
PubMed1981

[Left ventricular function at rest and during leg raising in patients with cardiomyopathy (author's transl)].

Isovolumetric and auxotonic contractility parameters were analyzed at rest and following leg raising in 16 patients with predominantly congestive cardiomyopathy. Regional ventricular function was calculated using the hemiaxis method. In patients with mild cardiomyopathy, ventricular function improved following leg raising with an increase in the mean velocity of circumferential fiber shortening and a decrease in endsystolic volume. By contrast, patients with moderate and severe cardiomyopathy displayed deterioration of ventricular function with increased hypokinesia, particularly in the anterior and apical region. Endsystolic volume increased; mean velocity of circumferential fiber shortening, regional wall velocity, and ejection fraction decreased. These results suggest that in the early phase regional disturbances of ventricular function may regress in response to passive leg raising. In the severe forms of cardiomyopathy, the preexisting regional or generalized hypokinesia increased markedly following leg raising, reflecting limited or absent left ventricular contractility reserve.

Adult↗