[Proceedings: Prolactin-cell-adenomas. Histochemical, immunohistological and electron-optic studies].
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Adenoma, Chromophobe↗
Biomedical subjects
W Saeger
Publications and source records attributed to W Saeger.
[Ultrastructure of the gonadotropic cells of the pituitary gland in rat following administration of antiandrogens (author's transl)].
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Aminoglutethimide↗
[Ultrastructure of hyperplastic and adenomatous corticotrophic cells in Cushing's syndrome of hypothalamic-hypophyseal origin (author's transl)].
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Adenoma↗
[Ultrastructure of the corticotrophic cells of the pituitary gland in rat following administration of steroidogenesis-inhibitors and methylprednisolone (author's transl)].
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Adrenal Cortex Hormones↗
[The ultrastructure of the atrophic adrenal cortex in dissociated secondary adrenocortical insufficiency (author's transl)].
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Adenoma↗
[Ultrastructure of pituitary adenomas in Cushing's syndrome after adrenalectomy (author's transl)].
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Adenoma↗
[Ultrastructural study of the adrenal tumours in Cushing's syndrome (author's transl)].
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Adenoma↗
Light and electron microscopy of parathyroid carcinoma. Report of three cases.
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Adult↗
[Pathology of Cushing's syndrome].
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Adenoma, Acidophil↗
[Light- and electron microscopic studies of pituitary adenomas in acromegaly with regard to their secretory activity].
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Acromegaly↗
Fine structure of corticotrophic cells and of pituitary adenomas in Cushing's syndrome.
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Adenoma↗
[Proceedings: Ultrastructural studies on the rat hypophysis following administration of cortisol-synthesis inhibitors and methylprednisolone].
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Animals↗
[Light and electron microscopic studies of the zona glomerulosa in rat adrenals following carbenoxolone-sodium treatment].
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Adrenal Glands↗
[Cytology of the anterior pituitary in adrenocortical hypoplasia with hypoglycaemia].
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Adrenal Glands↗
[Absorption of various biological wound adhesives and lyophilized dura in animal experiments].
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Animals↗
[Ultrastructural study of adrenal cortex in Cushing's syndrome].
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Adolescent↗
[Radioisotope diagnosis of slowly growing gliomas].
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Adult↗
Hormone production in pituitary adenomas following external irradiation: an experimental study in rats.
INTRODUCTION: The aim of this study was to investigate the hormone production in pituitary gland tumors following fractionated external irradiation in rats. MATERIALS AND METHODS: Sixty female Wistar rats 3 to 4 month of age at the beginning of the experiments, were subjected to fractionated roentgen-rays exposure, 2 Grays (Gy) daily, either up to 20, 40 or 60 Gy. The animals were sacrificed either 6 month or 1 year after completion of the randomly assigned irradiation protocol. RESULTS: We found 9 pituitary tumors in 60 irradiated rats (15%). All tumors proved to be adenomas. Immunohistochemical analysis of hormone production in remnants of the normal adenohypophysis revealed immunoreactivity for growth hormone (GH), adrenocorticotropic hormone (ACTH), prolactin (PRL), thyroid-stimulating hormone (TSH), and follicle-stimulating hormone (FSH). In adenomas, 4 cases were immunoreactive for TSH, 4 for GH, 2 for PRL, and 2 for FSH. The tumors were not reactive with anti-ACTH and anti-LH (luteinizing hormone). DISCUSSION: We concluded that irradiation accelerates the development of pituitary gland adenomas. In our series these tumors were predominantly incidental findings at necropsies after pre-termed follow-up, with a variety of hormone producing tumor cells. However, 4 of 9 tumors in our study were not producing hormones.
Animals↗