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Biomedical subjects

W S Teo

Publications and source records attributed to W S Teo.

At least 19 recordsLinked to original sources
PubMed2002

Slow-infusion of calcium channel blockers in the emergency management of supraventricular tachycardia.

OBJECTIVE: To compare the efficacy of verapamil and diltiazem as slow infusions in terminating spontaneous supraventricular tachycardia (SVT) in the emergency department (ED). METHOD: Patients of at least 10 years of age who presented to our ED with regular narrow complex tachycardia not converted with a vagal manoeuvre with an ECG diagnosis of SVT were included. Those who were haemodynamically unstable were excluded. Patients were randomized to undergo either verapamil infusion at a rate of 1 mg/min to a maximum of 20 mg or diltiazem infusion at a rate of 2.5 mg/min to a maximum of 50 mg. RESULTS: Eighty-one patients were randomized to receive verapamil infusion and 80 were randomized to receive the diltiazem infusion. There is no difference in success rate between verapamil (98.8%) and diltiazem (96.3%) infusion. The dose of medication required to convert 25,50 and 75% of SVTs were 4.0,5.0 and 8.0 mg for the verapamil infusion and 10.0,12.5 and 17.5 mg for the diltiazem infusion. There was one complication in each group. CONCLUSION: Calcium channel blockers infusions were safe and efficacious in terminating spontaneous SVT. There was no difference between the success rates of verapamil and diltiazem infusions.

Calcium Channel Blockers↗
PubMed2002

Two case reports on incessant left ventricular tachycardia: curative therapy with radiofrequency ablation.

INTRODUCTION: Incessant ventricular tachycardia is a rare arrhythmia which can be life threatening. Treatment with anti-arrhythmic agents may occasionally fail. CLINICAL PICTURE: We report 2 cases of incessant ventricular tachycardia. The first case was a young man with idiopathic left ventricular tachycardia who was in incessant ventricular tachycardia despite treatment with multiple anti-arrhythmic drugs and developed dilated cardiomyopathy. The second case was an asymptomatic girl with the incidental finding of an incessant ventricular tachycardia which originated from the left ventricular outflow tract. TREATMENT AND OUTCOME: Both patients underwent electrophysiologic study and radiofrequency ablation with complete termination of the tachycardia. CONCLUSION: Radiofrequency catheter ablation in experienced centres should be the first-line therapy for incessant ventricular tachycardia.

Adolescent↗
PubMed2001

Dual-site atrial pacing for atrial fibrillation in patients without bradycardia.

Atrial pacing has been shown to delay the onset of atrial fibrillation (AF) when compared with ventricular pacing in patients with sick sinus syndrome. The role for pacing in the control of AF in patients without bradycardia is uncertain. We performed a randomized, crossover, single-blinded study in 22 patients (14 women, aged 63 +/- 10 years) with paroxysmal AF refractory to treatment with oral sotalol (202 +/- 68 mg/day) and no bradycardic indication for pacing. All patients received a dual-chamber pacemaker with 2 atrial pacing leads positioned at the high right atrium and coronary sinus ostium, respectively. Patients were randomized in a crossover fashion to be paced for 12 weeks, either with high right atrial (RA) pacing at 30 beats/min ("Off") or dual-site RA pacing with an overdrive algorithm that maintained atrial pacing at a rate slightly above the sinus rate ("On"). Treatment on resulted in a significantly higher percentage of atrial pacing and a reduction in atrial ectopic frequency than the treatment off period. The time to the first clinical AF recurrence was prolonged (15 +/- 17 to 50 +/- 35 days, p = 0.006), and total AF burden was reduced (45 +/- 34% vs 22 +/- 29%, p = 0.04) in the on-treatment phase. However, there was no difference in AF checklist symptom scores or overall quality-of-life measures. Dual-site RA pacing with continued sinus overdrive prolonged the time to AF recurrence and decreased AF burden in patients with paroxysmal AF. The absence of a major impact on symptom control suggests that pacing should be used as an adjunctive therapy with other treatment modalities for AF.

Adolescent↗
PubMed2001

A case series of drug-induced long QT syndrome and Torsade de Pointes.

INTRODUCTION: Torsade de Pointes (Tdp) is a form of polymorphic ventricular tachycardia in the setting of prolonged QT interval. Any drug that prolongs repolarisation, and hence QT interval, may cause Tdp. Predisposing factors of drug-induced Tdp include female sex, bradyarrhythmia and hypokalaemia. METHODS: We retrospectively analysed the case notes of 13 patients with drug-induced LQTS from 1991 to 2000 from National Heart Centre and Changi General Hospital. RESULTS: Causative drugs in the series were amiodarone (seven patients, 54%), sotalol (two patients), quinidine (one patient), phenothiazine (two patients) and astemizole (one patient). There were eight females and all were Chinese. The mean age was 72 +/- nine years. The patients commonly present with syncope (38%) and cardiac arrest (38%). The mean corrected QTC interval was 545 ms. The most common precipitating factor was hypokalaemia (31%). Nine patients require cardiopulmonary resuscitation and two patients (15%) died. Nine patients (69%) had underlying structural heart disease such as ischaemic heart disease, valvular heart disease and hypertensive heart disease. The left ventricular ejection fraction was normal in six patients. The onset of Tdp ranged from Day 2 to Day 5 in the seven patient with amiodarone-induced LQTS. These were inpatients who were given intravenous loading doses of amiodarone. Both patients with sotalol-induced LQTS were females on sotalol 80 mg and 240 mg per day with Tdp occurring on Day 2 and 10 months respectively. CONCLUSION: Tdp is a potentially life-threatening arrhythmia. The list of torsadogenic drugs is ever expanding. Physicians need to know the drugs which can lead to Tdp. Careful assessment of risk-benefit ratio is important before prescribing such drugs. Amiodarone-induced Tdp is not uncommon in our local population. Initiation of a class III agent, especially amiodarone, should be done judiciously, with monitoring of the QT interval and avoidance of hypokalaemia.

Aged↗
PubMed2000

Electrocardiographic case: diagnosis of acute myocardial infarction in the presence of left bundle branch block.

The electrocardiographic features associated with acute myocardial infarction (AMI) are often easily recognised. However, interpretation is made more difficult in the presence of confounding patterns such as a left bundle branch block (LBBB). This may result in missed cases which may otherwise have benefited from acute revascularisation therapy. Though not straightforward, the diagnosis of AMI in the presence of LBBB can be made with a reasonable amount of accuracy. We report a case of acute myocardial infarction with LBBB that was appropriately diagnosed and underwent acute revascularisation by angioplasty. A detailed knowledge of the typical electrocardiographic features associated with LBBB, especially the ST segment morphologies, is very important. This will greatly aid recognition of an evolving AMI and help us decide on the most appropriate therapy.

Bundle-Branch Block↗
PubMed2000

The differential diagnosis of supraventricular tachycardia using clinical and electrocardiographic features.

INTRODUCTION: Noninvasive determination of the mechanism of supraventricular tachycardia (SVT) is useful in order to decide on the appropriate mode of therapy. The aim of this study was to evaluate the usefulness of the clinical and electrocardiographic features in diagnosing the type of SVT. METHODS: Design--A retrospective review of case records and electrocardiograms (ECG) of patients with definitive diagnosis of the mechanism of supraventricular tachycardia (SVT) made during electrophysiological study (EPS) and catheter ablation. Setting--A tertiary referral centre for electrophysiological studies and radiofrequency catheter ablation of arrhythmias. Sample--One hundred consecutive patients with SVT who had EPS and catheter ablation at our institution. Chief Outcome--Comparison of clinical and ECG pacemeters among 3 different types of SVT, namely atrioventricular nodal reentrant tachycardia (AVNRT), atrioventricular reentrant tachycardia (AVRT) and atrial tachycardia (AT). RESULTS: There were 68 atrioventricular nodal reentrant tachycardia (AVNRT), 26 atrioventricular reentrant tachycardia (AVRT) and 6 atrial tachycardia (AT). AVRT had the earliest mean age of presentation at 26.8 +/- 11.9 years. Sex and age of onset of symptoms alone were, however, not valuable in diagnosing the type of SVT. P waves were more discernible in AVRT and AT than in AVNRT (69%, 67% and 44% respectively, P = 0.071). AVNRT had the shortest mean RP' interval (86.3 +/- 47.6 msec), while AT had the longest (187 +/- 80.6 msec, P < 0.0001). Conversely for mean P'R interval, AT had the shortest (125 +/- 30 msec), AVNRT had the longest (262.7 +/- 73.7 msec, P = 0.001). AVNRT had the smallest mean RP':P'R ratio (0.6 +/- 0.9), while AT had the largest (2.2 +/- 0.6, P = 0.001). The presence of pseudo r' in V1 and pseudo s' in II/III/aVF was diagnostic of AVNRT with a specificity of 90% and 100%, respectively, and positive predictive value of 97% and 100%, respectively. CONCLUSION: Pseudo s' in II/III/aVF is highly predictive of AVNRT. Measurement of RP' and PR' interval and ratio are also useful in determining the SVT mechanism.

Adolescent↗
PubMed2000

Initial experience with an autocapture pacemaker system.

INTRODUCTION: Autocapture management aims to extend pacemaker longevity without compromising on patient safety by automatically monitoring the pacing threshold and adjusting the pacemaker output for consistent capture. This paper describes our initial experience with the Pacesetter Regency pacemaker with autocapture management. MATERIALS AND METHODS: Nineteen patients were implanted with single chamber pacemakers with autocapture management. Autocapture was programmed "ON" the day after implantation if Evoked Response (ER) amplitude was at least 2.8 mV. The patients were followed up at 2 weeks, 2 months and 6 months. At each visit, pacing threshold and lead impedance were measured. Autocapture was turned "ON" during follow-up if it had not been done previously. RESULTS: In 16 out of 19 patients, autocapture could be turned "ON" the day after implantation. One patient had an ER signal that was less than 2.8 mV and 2 patients were in fast atrial fibrillation of more than 120 beats per minute which precluded ER signal testing. These patients could not have autocapture programmed "ON". CONCLUSION: The benefits of autocapture management can only be realised if an ER signal of at least 2.8 mV is obtained. This requires intraoperative testing of the ER signal. Since there is no commercially available pacing system analyser presently that can measure this, modification of the standard implantation procedure with some prolongation of procedure time is needed.

Aged↗
PubMed1999

Curative therapy of cardiac tachyarrhythmias with catheter ablation--a review of the experience with the first 1000 patients.

INTRODUCTION: Cardiac tachyarrhythmias present as supraventricular or ventricular tachycardia. Catheter ablation has completely revolutionised the treatment of patients with these arrhythmias. METHOD: We reviewed the experience of radiofrequency catheter ablation in a single centre. RESULTS: A total of 1,022 patients underwent radiofrequency catheter ablation from October 1991-December 1997. There were 480 patients who had AV nodal re-entrant tachycardia, 429 patients with accessory pathways, 7 patients with both AV nodal re-entrant tachycardia and accessory pathways, 4 patients with both AV nodal re-entrant tachycardia and atrial tachycardia. Twenty-seven patients had atrial tachycardia ablation, 28 had atrial flutter ablation and 11 patients had AV node ablation for atrial fibrillation. The mean age of the supraventricular tachycardia patients was 41 +/- 15 years (10-80 years). The mean duration of procedure was 108 +/- 60 minutes (15 to 480 minutes) and the mean fluoroscopy time was 19 +/- 17 minutes (3-122 minutes). Another 14 patients had ablation for right ventricular outflow tract ventricular tachycardia and 22 patients had ablation for idiopathic left ventricular tachycardia. The mean age of the ventricular tachycardia patients was 35 +/- 14 years (19-65 years). The mean duration of the ventricular tachycardia ablation procedure was 185 +/- 63 minutes (110-285 minutes) and the duration of fluoroscopy was 33 +/- 16 minutes (range 14-68 minutes). Of the 1,022 patients, 1,002 (98%) of the patients were successfully ablated. There were significant complications in less than 1% of the patients and no mortality associated with the procedure. The recurrence rate was 5% and could be successfully reablated when the procedure was repeated. CONCLUSION: Radiofrequency catheter ablation is thus an extremely safe and successful procedure and has replaced drug therapy as the treatment of choice for patients with supraventricular tachycardia and non-ischaemic ventricular tachycardia. It provides curative therapy without the need for life-long drug therapy.

Adolescent↗
PubMed1999

T wave alternans and acute rheumatic myocarditis: a case report.

T wave alternans is an uncommonly recorded cardiac rhythm. We report here an unusual case of a 13-year-old girl with acute rheumatic carditis and acute nephritis, who developed T wave alternans associated with a prolonged QT interval. These electrocardiographic changes were evident only after the initial acute stage of the disease process and should be borne in mind for patients with acute rheumatic carditis as they may be associated with more malignant arrhythmias.

Acute Disease↗
PubMed1999

Incessant ectopic atrial tachycardia and tachycardia-related cardiomyopathy: therapeutic options and potential for cure.

Incessant ectopic atrial tachycardia (IEAT) is a rare cause of cardiomyopathy. Cardiomyopathy is reversible by curative ablation using surgery or radiofrequency current. We report our experience with 5 patients with IEAT. Three patients presented with palpitations and were diagnosed to have paroxysmal supraventricular tachycardia (2 patients) and atrial flutter with 1:1 conduction (1 patient), but 2 presented insidiously with congestive cardiac failure. All the initial echocardiograms showed left ventricular dysfunction. The patients underwent electrophysiological studies which confirmed the diagnosis of IEAT. The first patient had surgical cryoablation and the other patients had successful radiofrequency catheter ablation. Follow-up for 2 to 7 years has shown no recurrences. All patients had significant improvement in left ventricular function on echocardiography. In conclusion, curative ablation by surgery or radiofrequency current is safe and effective. Because of its low morbidity, radiofrequency catheter ablation should be the treatment of choice for IEAT, especially if complicated by tachycardia-related cardiomyopathy.

Adolescent↗
PubMed1999

Treatment and prevention of sudden cardiac death--what have we learnt from randomised clinical trials?

Sudden cardiac death is most commonly caused by ventricular tachycardia or fibrillation. Three groups of patients at highest risk for sudden cardiac death are survivors of previous sudden cardiac death, those with recurrent documented episodes of sustained ventricular tachycardia and patients with recurrent syncope of unknown origin. The experience with antiarrhythmic drugs has been discouraging. Only beta-blockers have been shown to unequivocally reduce both arrhythmic and total mortality in randomised trials. Class I antiarrhythmic drugs increase mortality, especially in an ischemic substrate. Class III drugs such as sotalol and amiodarone have had variable success. Racemic sotalol has both beta-blocker as well as Class III actions and some of the benefits may be due to the former effect. D-sotalol which has only pure Class III action, increases mortality in the post myocardial infarction patient. Amiodarone is superior to Class I antiarrhythmic drugs for patients with previous cardiac arrest. In the high-risk myocardial infarction patient, it seems to reduce sudden death but not total mortality. In the cardiac failure patient, the effect of amiodarone on total mortality is controversial. Several randomised trials of implantable cardioverter-defibrillator (ICD) therapy versus drugs have however concluded that the ICD is superior to drugs in reducing total mortality. In comparison with many other high volume therapies used in medicine today, ICD is still a cost-effective therapy.

Adrenergic beta-Antagonists↗
PubMed1999

Pacemaker implantation in Singapore in 1997.

INTRODUCTION: Previous reports on pacemaker implantation in Singapore have been from a single institution and hence may not accurately reflect the practice in Singapore. As part of the World survey on pacemaker implantation, a survey of all pacemaker implantations in Singapore in 1997 was performed. METHOD: Information was obtained from the pacemaker manufacturers and a survey form was sent to all doctors involved in pacemaker implantation. RESULT: In 1997, 206 pacemakers were implanted or replaced in Singapore. This gives a pacemaker rate of 69 per million. For new implants only, there were 61 implants per million. More detailed information regarding the patient and implantation was obtained in 160 (78%) patients. The mean age of the patients was 68.5 +/- 14.4 years (range 2-97 years). There were 142 (89%) new implants and 18 (11%) replacements. 62.5% of the patients were females. Seventy-nine percent of the patients were older than 60 years old and 17.5% were older than 80 years. Seventy-five percent of the pacemakers were single chamber pacemakers. Twenty-five percent were dual chamber pacemakers. Only 1.4% of the pacemakers used epi-myocardial leads and all these were in children. Heart block was the most common indication for pacing and consisted of 52.8% of the patients while 43.0% of patients were implanted for the sick sinus syndrome. CONCLUSION: Pacemaker implantation in Singapore in 1997 was 69 per million. Heart block remains the most common indication for implant and single chamber pacing is still the most commonly used mode of pacing. The majority of the implants were in persons older than 60 years. With an increasing ageing population in Singapore, the implant rate for pacemakers will be expected to increase significantly.

Adolescent↗
PubMed1998

The Brugada syndrome in a Chinese population.

Sudden cardiac death has been reported in patients with a unique electrocardiographic (ECG) abnormality showing right bundle branch block and ST segment elevation in the precordial leads. This syndrome was first described by Brugada and Brugada and has not been previously described in a Chinese population. We report here the first three cases in Singapore. The first patient was a 49-year-old man who presented with syncope, associated with generalized convulsions. The second patient was a 25-year-old man who complained of palpitations but no syncope. The third patient was a 77-year-old man who presented with recurrent episodes of syncope and collapsed with ventricular fibrillation. All patients had no past cardiac or drug history of note. The neurological examination and investigations were normal. All three patients showed a unique right bundle branch block pattern with ST segment elevation in leads V1-3. The echocardiogram and 24-h ambulatory ECG monitoring, were normal. Single vessel disease was present in the third patient. Electrophysiological studies performed in all three patients were able to induce ventricular fibrillation. The patient with resuscitated cardiac death underwent an implantable cardioverter defibrillator implantation. The importance of this syndrome is that the recognition of the unique ECG pattern enables early identification and treatment of these patients.

Adult↗
PubMed1998

Comparison of treatment of supraventricular tachycardia by Valsalva maneuver and carotid sinus massage.

STUDY OBJECTIVE: To compare the efficacy of the Valsalva maneuver with that of carotid sinus massage (CSM) in terminating paroxysmal supraventricular tachycardia (SVT) in the ED. METHODS: This prospective, randomized case study was performed in the ED of a tertiary care institution. Patients were at least 10 years of age with regular narrow complex tachycardia and had an ECG diagnosis of SVT. Patients with regular narrow complex tachycardia were randomly assigned to undergo either the Valsalva maneuver or CSM. If the tachycardia was not terminated by the method chosen by randomization, then the alternative method of vagal maneuver was used. If the tachycardia was not converted by both methods of vagal stimulation, patients would undergo either synchronized electrical cardioversion or a pharmacologic method of conversion at the discretion of the treating physician, depending on the patient's hemodynamic status. RESULTS: One hundred forty-eight instances of SVT were studied Sixty-two patients underwent Valsalva maneuver first with conversion in 12 (success rate of 19.4%). Eighty-six underwent CSM first with conversion in 9 (success rate 10.5%). Carotid sinus massage was used in the 50 cases of SVT in which conversion was not achieved with the Valsalva maneuver. Conversion occurred in 7 cases (success rate 14.0%). For the 77 cases of SVT in which initial CSM did not achieve conversion, conversion occurred in 13 with the Valsalva maneuver (success rate 16.9%). The Valsalva maneuver and CSM achieved conversion in a total of 41 instances of SVT (success rate 27.7%). CONCLUSION: Vagal maneuvers are efficacious in terminating about one quarter of spontaneous SVT cases. There is no detectable difference in efficacy between the Valsalva maneuver and CSM.

Adult↗
PubMed1998

Interventional electrophysiology and its role in the treatment of cardiac arrhythmia.

Cardiac arrhythmias can present as benign ectopics or as life-threatening arrhythmias and sudden cardiac death. Clinical cardiac electrophysiology is the study of the electrophysiology of the heart and all aspects of management of cardiac arrhythmias. The invasive electrophysiological study was initially purely diagnostic, but recent advances in technology has allowed us to intervene and hence the term interventional electrophysiology. The interventional therapies include permanent pacing for bradyarrhythmias, arrhythmia surgery for arrhythmias, percutaneous catheter ablation and implantable devices for tachyarrhythmias. The treatment of bradyarrhythmias with permanent pacemaker implantation represents the first interventional therapy for patients with cardiac arrhythmias. From 1973 to June 1996, a total of 791 pacemakers have been implanted at the Singapore General Hospital. Previously, patients with tachyarrhythmias could only be cured by open heart surgery utilising intraoperative map guided surgery and ablation of the arrhythmia. Only 17 patients with supraventricular tachycardia (SVT) and 3 patients with VT have undergone this procedure. Catheter ablation has completely revolutionised the treatment of these patients. From October 1991 until December 1996, 860 patients have undergone radiofrequency (RF) catheter ablation for SVT and non-ischaemic VT. Ninety-eight per cent of the patients with SVT have been successfully ablated and 94% of the patients with VT were successfully ablated. RF ablation has become the technique of choice to cure patients with recurrent paroxysmal SVT due to AV re-entrant tachycardia using an accessory pathway, AV nodal re-entrant tachycardia, atrial tachycardia and atrial flutter. It is also used for AV nodal ablation followed by pacemaker insertion or AV nodal modification in patients with poorly controlled atrial fibrillation. Patients with idiopathic non-ischaemic VT arising from the left ventricle or right ventricular outflow tract can similarly be cured. For all these patients, RF ablation offers curative therapy, thus eliminating recurrent symptoms, life-threatening attacks, tachycardia cardiomyopathy and need for life-long drug therapy. For patients with resuscitated sudden cardiac death or at high risk for sudden death, the implantable cardioverter defibrillator (ICD) is the only technique that has significantly improved survival from sudden cardiac death. Since August 1992, 11 patients have had the ICD implanted, with 9 surviving. The 2 deaths were due to cardiac failure and not to sudden death. Thus the ICD can prevent sudden death, but the main limitation is the cost of the device and it is not suitable in patients who have severe heart failure. In conclusion, interventional electrophysiology represents a tremendous leap forward in the management of cardiac arrhythmias. With catheter ablation, it offers a safe curative therapy for patients with recurrent SVTs and VTs and with the ICD, prevents sudden cardiac death in patients who have been resuscitated from it or who are at risk for it. The future will see us improving our success in ablating patients with monomorphic ischaemic VT and even atrial fibrillation, and the role of prophylactic ICDs in high risk patients will be better defined.

Arrhythmias, Cardiac↗