Search PubMed⌕ Search

Biomedical subjects

W S Hunter

Publications and source records attributed to W S Hunter.

90 records · Page 5Linked to original sources
PubMedDate not supplied

Stereotaxic implant microinjection and temperature recording system for rabbits.

Modification of standard rabbit stereotaxic apparatus to allow adjustment of the tooth bar in the vertical plane may be accomplished by simple machining of a standard laboratory clamp and aluminum rod. The modification greatly increases speed of head positioning for implant surgery. Machining the chrome and brass luer hub of standard stainless steel hypodermic needles to the described configurations produces improved guide tubes for brain temperature recording and cannulae for brain microinjections. Data from hypothalamic injection of prostaglandin E1 and records of resulting changes in brain temperature support the effectiveness of the methods described.

Animals↗
PubMedDate not supplied

Does growth hormone prevent or accelerate aging?

It is very well documented that plasma growth hormone (GH) levels decline with age in the human and in experimental animals, and there is considerable evidence that age-related changes in body composition may be caused by reduced function of the GH-IGF-I system. However, excessive GH levels are associated with reduced life expectancy in acromegalic patients and with symptoms of accelerated aging in GH transgenic mice. Hereditary dwarf mice deficient in GH, prolactin, and TSH live much longer than their normal siblings. Possible mechanisms of delayed aging in dwarf mice include lower core body temperature and reduced oxidative processes. It is suggested that the controversies concerning the apparent potential of GH to both prevent and accelerate aging may be reconciled by interpreting the results in light of the negative relationship between body size and life span within a species.

Aging↗
PubMedDate not supplied

Hemolytic glaucoma.

Explore the source record for details and available documents.

Aged↗