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Biomedical subjects

W S Hare

Publications and source records attributed to W S Hare.

At least 19 recordsLinked to original sources
PubMed1992

The cervical spine in fatal motor vehicle accidents.

Of 100 fatal accident cases involving motor vehicles, 60 showed damage to the cervical spine, involving bony or disc damage in 31 and focal haemorrhages in another 29. In 8 cases, pre-autopsy radiology failed to detect lesions which were found by radiology and pathological examination of the post-autopsy specimen. Most of the lesions missed were at the C6-7 region. In some cases, the initial pathological examination 'missed' laterally placed fractures and small chip fractures. Narrow cervical canals in the elderly indicated advanced spondylosis.

Accidents, Traffic↗
PubMed1991

Teleradiology.

Explore the source record for details and available documents.

Australia↗
PubMed1991

Outpatient transurethral balloon urethroplasty.

Transurethral balloon dilatation was performed on 6 patients, who were assessed pre- and post-procedure on symptomatic and urodynamic criteria. Follow-up was on average 11.7 months. Only 1 patient had a successful result, despite early initial improvement in five. In view of our results and reports from other centres we cannot recommend transurethral balloon dilatation of the prostate as treatment in patients with bladder outlet obstruction due to benign prostatic hypertrophy, except in exceptional circumstances.

Aged↗
PubMed1990

CT of the spine: are plain spine radiographs necessary?

This study was designed to determine whether plain radiographs added any information of clinical significance to the information provided by CT (computed tomography) and its standard digital radiographs in 100 patients presenting for CT of the lumbar spine and 46 patients presenting for cervical spine CT. In only three (3%) of the lumbar studies and two (4.3%) of the cervical studies did the plain radiographs add diagnostic information. The added diagnostic information did not affect patient management in all cases with indications other than trauma. Good quality oblique cervical spine digital radiographs were obtained in 10 cases simply by moving the tube and detectors to the 45 degrees and 135 degrees azimuths. The evidence from this study suggests that when a CT examination of lumbar or cervical spines is planned on a high resolution CT scanner for indications other than trauma, a conventional plain radiographic examination can be omitted in the first instance.

Cervical Vertebrae↗
PubMed1989

The relation of radionuclide uptake by bone to the rate of calcium mineralization. I: Experimental studies using 45Ca, 32P and 99Tcm-MDP.

The study of the uptake of radionuclides by bone has been undertaken in a mouse tail graft model using 45Ca, 32P and a routine bone scanning agent 99Tcm-MDP, together with serial calcium determinations. The model provided an experimental system in which the calcium mineral content and the rate of mineralization both changed progressively throughout its development. A significant linear correlation was found between 45Ca and 32P uptake and the rate of calcium mineralization, which held for all stages of the graft's growth. Both radiotracers therefore accurately reflected the calcium mineral deposition. In the case of 99Tcm-MDP, the correlation with mineralization rate only applied for the most active growth period of the graft when the rate was increasing. For all radiotracers, the peak in bone uptake corresponded to the maximum in mineralization rate.

Animals↗
PubMed1989

The relation of radionuclide uptake by bone to the rate of calcium mineralization. II: Patient studies using 99Tcm-MDP.

The relation of radionuclide uptake by bone and rate of calcification has been studied in normal vertebrae and in vertebral metastases from cancer of the prostate. Specifically, the determination of 99Tcm-MDP uptake by radionuclide scanning and the estimation of calcium concentration of trabecular bone by dual-energy computed tomography have provided the means of obtaining a relation between these parameters which was similar to that found in an animal model, in which the dependence of radionuclide uptake on the rate of mineralization was established. This relationship has enabled the experimental findings to be extrapolated to those in patient studies and has shown that in sclerotic bone lesions, the increase in 99Tcm-MDP uptake accompanying the progression of the metastases was proportional to the rate of calcification.

Aged↗
PubMed1988

Comparison of mammary serum antigen assay with mammography in patients with breast cancer.

Mammary serum antigen levels and two-view xeromammography were evaluated in a study of 97 patients who presented at a specialist breast clinic in a major teaching hospital, in order to determine their single and combined value in the detection of breast cancer. Raised mammary serum antigen levels (greater than 300 inhibition units) were found in 76% of patients with stage-1 (including carcinoma-in-situ) and stage-II breast cancer compared with 54% of patients whose mammograms were suggestive of cancer (probability of carcinoma, greater than 50%). Four patients with carcinoma-in-situ had elevated mammary serum antigen levels, but their mammograms did not suggest the presence of cancer (probability of carcinoma, less than 50%). The over-all sensitivity, specificity and predictive value of a positive test-result in detecting breast cancer were 76%, 82% and 72%, respectively, for the mammary serum antigen test, and 54%, 88% and 74%, respectively, for mammography. When the mammary serum antigen test and mammography were used together, a combined evaluation enhanced the sensitivity in the detection of breast cancer (89%) but with a concomitant reduction in specificity (72%). The mammary serum antigen test was superior to mammography in the detection of breast cancer in this study and may prove to be a useful adjunct to conventional methods of clinical assessment and to mammography for the detection of breast cancer.

Adult↗
PubMed1986

Glucagon and ureteric calculi.

Glucagon may act as a relaxant of smooth muscle and it has been suggested that this action may assist in the passage of ureteric calculi and diminish ureteric colic. These effects may be of clinical use to avoid inpatient admission to hospital for the symptomatic relief of ureteric colic. Ten successive patients with acute ureteric colic were given 1 mg of glucagon and two litres of fluid administered by the intravenous route and analgesia as required over three hours. Progress was monitored radiologically and clinically. In no case did significant progression or passage of stones occur and seven patients required parenteral analgesia. We conclude that glucagon is not effective for the management of ureteric colic in a casualty department.

Adult↗
PubMed1986

Ureteral calculi: percutaneous removal using modified basket extractors and fluoroscopy.

Two modified helical basket extractors are described that have increased the success rate of removing ureteral calculi using fluoroscopy from 63% to 92%. Initially a rather stiff and expandable basket with a 20-cm filiform tip is used with coaxial catheters and sheath (stage 1). If this procedure is unsuccessful, a basket with two long cable ends is passed from the nephrostomy out through the urethra (stage 2). When used with coaxial bladder catheters, this technique allows dilatation of the vesicoureteric junction and retrograde catheterization and injection of fluids or gas to dislodge the stone prior to extraction. In a series of 38 patients, stones were removed in all but three (a success rate of 92%). In five cases small stones (less than 5 mm) were not retrieved but subsequent studies were normal. Ureteral stones were found in the abdominal ureter in 28 cases, in the pelvic ureter in seven cases, and in multiple sites in three cases. Stones were larger than 1 cm in 27.7% of cases. Postextraction mucosal edema with reduced ureteral patency was common but usually cleared in 2-3 days. Occasional complications were related to the nephrostomy.

Fluoroscopy↗
PubMed1985

Percutaneous ultrasonic disintegration and removal of renal calculi.

The results of percutaneous renal stone removal in the first 50 patients to undergo this procedure are presented. The procedure was successful in 40 patients; in 16 of these, ultrasonic disintegration was necessary. The technique failed in 10 patients. The difficulties encountered and the resulting modifications of technique are described.

Dilatation↗