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Biomedical subjects

W Rudowski

Publications and source records attributed to W Rudowski.

At least 73 records · Page 4Linked to original sources
PubMed1976

Effects of stroma-free haemoglobin solution on the blood-clotting system in dogs.

The effect of transfusions of 500 ml of 5-6% stroma-free haemoglobin solutions on the blood-clotting system of dogs was studied. Slight lowering of the fibrinogen level and of the activity of clotting factors V, VII, VIII, IX and X was observed, together with some prolongation of the thrombin time. In vitro investigations indicate that prolongation of the thrombin time may depend on disturbed polymerization of fibrin monomers. After transfusion of stroma-free haemoglobin preparation, no signs of haemorrhagic diathesis were observed.

Animals↗
PubMed1976

[Hematologic and surgical problems connected with splenectomy in elderly patients].

The authors carried out a clinical analysis of problems connected with splenectomy in elderly patients treated surgically at the Institute of Haematology in the years 1965-1972. Out of 24 patients aged above 60 years 12 were analysed clinically (8 females and 4 males). Splenectomy was done in these patients from haematological indications (haemolytic anaemia, thrombocytopenia, pancytopenia). In all these cases indications to splenectomy, the course of operation and postoperative period as well as late therapeutic results were assessed. The analysis of these elderly patients showed that the criteria of indications for splenectomy were the same as in other age groups. The choice of surgical method depended in these cases on the clinical and haematological findings, a lack of permanent improvement after conservative treatment, contraindications to immunosuppressive treatment and results of isotope investigations (particularly the values of the spleen-liver index). In most splenectomized patients there were no complications during the operation and in the postoperative period. In 2 cases only acute circulatory failure was observed immediately after the operation. Evaluation of late results showed that the effects of the operation were similar to those in other age groups.

Age Factors↗
PubMed1976

Experimental investigations on the possibility of transplantation of venous grafts stored at low temperatures.

At the Laboratory of Experimental Surgery, Institute of Haematology in Warsaw 13 dogs received homografts of venous patches stored at low temperatures to fill defects in the wall of the lower caval vein. Venous patches were prepared from segments of femoral veins and were placed in 1.41 M DSMO and stored at the temperature of liquid nitrogen. The authors describe the methods of obtaining venous patches, the technique of freezing and defreezing of grafts, and details of operations. Full healing in of grafts took about 15 days. The results of histological examinations of grafts obtained during planned autopsies between 12 and 29 days after application of the graft are discussed.

Animals↗
PubMed1976

Oxygen consumption by hepatic tissue after transfusion of a stroma-free haemoglobin solution.

The ability of stroma-free haemoglobin solutions to transport oxygen was investigated by determining the oxygen consumption by the liver using Warburg's microrespirator. 50 ml of blood were removed from the rabbit under general anaesthesia and replaced by an identical volume of a non-oxygenated or oxygenated haemoglobin solution. The control rabbits received no transfusions. It was found that arterial hypotension produced by blood-letting caused a significant rise in oxygen consumption by the hepatic tissue. The rise was increased even more when the rabbits received no transfusions. Transfusion of non-oxygenated haemoglobin solutions caused likewise a rise in oxygen consumption immediately after transfusion. This rise was, however, not so significant as in the control group. On the other hand, transfusion of oxygenated haemoglobin solutions produced no rise in the oxygen consumption by the liver as compared to its value after blood-letting.

Animals↗