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Biomedical subjects

W Rudowski

Publications and source records attributed to W Rudowski.

At least 181 records · Page 10Linked to original sources
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[Role of spleen in leukocyte kinetics in dog].

In 9 dogs blood samples were obtained from the splenic vein and artery under general anaesthesia with Eunarcon, the quantitative and qualitative composition of white blood cells was compared and it was found that canine spleen can release or retain granulocytes and mononuclear cells simultaneously or any of these cells separately.

Animals↗
PubMedDate not supplied

Differences in the composition of leucoyctes in the splenic artery and vein in rabbits, and dogs.

Differences in the composition of leucocytes in the splenic artery and vein in rabbits, and dogs. Acta Physiol. Pol. 1975, 26 (1): 33-39. Blood samples were taken from the splenic artery and splenic vein of 14 rabbits and 9 dogs under general anaesthesia (with hexobarbital sodium in rabbits and Eunarcon in dogs) to compare the quantitative and qualitative composition of white blood cells. It was found that the rabbit spleen releases into the circulation mononuclear cells which do not differ in their size from cells of the blood flowing into the spleen, and that it can retain or release granulocytes, probably due to their intravascular margination. The dog spleen can retain or release granulocytes and mononuclears simultaneously or separately, probably due to the mechanism which includes spontaneous contraction of the spleen.

Animals↗
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[Role of human spleen in the release and sequestration of white blood cells].

In 21 patients during operation blood samples were obtained from splenic vein and artery immediately before splenectomy for determination of qualitative and quantitative composition of white blood cells to establish the role of the spleen in their release and sequestration. It was found that the spleen released into circulation mononuclear cells whose number, size of nucleus and glycogen content of the cytoplasm varied individually in various cases. Besides that the spleen releases and sequestrates granulocytes, most probably as a result of intravascular shifts in the marginal and circulating cell pools induced, among others, by contractions of the spleen.

Humans↗
PubMedDate not supplied

[Effect of stroma-free hemoglobin solution on oxygen consumption in some tissues].

50 cc of a 6%, oxygenated or non oxygenated stroma-free heamoglobin solution was transfused in rabbits after previous removal of about one third of the circulating blood volume. The experimental investigations were carried out on animals under barbiturate anaesthesia. Oxygen consumption was determined using a Warburg microrespirator. Posthaemorrhagic hypotension developing after bleeding caused a significant increase in oxygen consumption by liver tissue. Transfusion of non oxygenated stroma-free haemoglobin solution caused a further increase of oxygen consumption, while transfusion of oxygenated stroma-free haemoglobin solution slightly decreased oxygen consumption compared to the values observed during the post haemorrhagic hypotension.

Animals↗
PubMedDate not supplied

Modern oxygen carriers: state of art 1990.

Three major components of blood with clearly defined functions are: 1) red cells 2) plasma volume 3) coagulation factors At the present time artificial or synthetic coagulation factors are not available. Plasma volume expanders are well known in clinical practice. The main subject of this paper is the complex area of red cell substitutes with particular reference to the oxygen carrying capacity. The history of blood oxygen carrying capacity is briefly presented with particular reference to contributions by G. S. Adair, C. Bohr, M. Perutz and R. R. Benesch. 3 oxygen carrying developments are discussed in detail: 1) perfluorocarbons 2) artificial red cells 3) stroma-free haemoglobin solution Perfluorocarbons were used as carriers of oxygen in experiments and clinical practice. Before their wide clinical application a number of potential problems must be solved. In selected patients (coronary angioplasty, cerebral thrombosis, cardiopulmonary by-pass) perfluorocarbons (Fluosol D-A) could be considered as beneficial. Artificial red cells (neohaemocytes) are available in some centres in which progress of micro-technology appears to lead to encapsulation of purified human haemoglobin. These preparations should receive more attention. Finally stroma-free haemoglobin solution was the subject of our own research for several years. Our preparation met the requirements of the blood substitute, but had the short half-life in the circulation. Recent advances in chemistry in some centres resulted in the modification of hb molecule and linking with P-5-P. The modified poly hb solution is an ideal oxygen delivering fluid.

Blood Substitutes↗
PubMedDate not supplied

[Thrombocytopenia in a patient with hemophilia and HIV infection treated with intravenous immunoglobulin and splenectomy].

In a patient with haemophilia B who had developed immune thrombocytopenia following HIV infection, high doses of intravenous immunoglobulin were administered. The therapy brought about only a temporary rise in platelet counts. No beneficial effects were also obtained during a 3-month treatment with corticosteroids. Since there was no response to the conservative therapy, the patient was splenectomized under the cover of factor IX concentrate and the surgical procedure resulted in a complete remission of the thrombocytopenia.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Results of using polyvalent Pseudomonas aeruginosa vaccine in children with burns by various medical centers].

Polyvalent Pseudomonas aeruginosa vaccine, prepared at the Institute of Hematology from 10 hospital strains isolated from burn wounds, was administered to 32 children with extensive and deep burns. The vaccine was well tolerated. The vaccine produced a high degree of the immunity against Pseudomonas aeruginosa infection. Agglutinin serum titre increased significantly. Vaccination either prevented or inhibited the infection of burn wounds with Pseudomonas aeruginosa in all immunized children. The symptoms of Pseudomonas aeruginosa infection usually disappeared following one or two vaccinations. Bacteriemia caused by P. aeruginosa was not observed in 31 out of 32 children. In the remaining child transient bacteriemia was noted. No septicemia caused by P. aeruginosa was seen. Due to the high efficiency of the polyvalent P. aeruginosa vaccine all burned children with burns exceeding 10% of the total body surface should by vaccinated to prevent the life-threatening infections with Pseudomonas aeruginosa.

Agglutinins↗