Will doxorubicin-containing regimens replace MOPP and its variants?
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Antineoplastic Combined Chemotherapy Protocols↗
Biomedical subjects
W Rosenberg
Publications and source records attributed to W Rosenberg.
Growth characteristics of human laryngeal carcinoma in athymic mice.
We report the growth characteristics of seven human laryngeal carcinomas transplanted into athymic mice. Six of the tumors were harvested from surgical pathology specimens and one was from a laryngeal carcinoma cell line. Tumor tissue measuring 2-3 cubic millimeters was implanted subcutaneously into the flank of the mice. Time intervals between implantation and active growth were recorded and tumor volume was calculated weekly. Mice were sacrificed at various time intervals. For three tumors, second and third passages of the tumor were performed. Successful tumor growth was achieved in 6/7 (85.7%) tumors. Primary implantation of tumor was performed in a total of 26 mice, 17 of which grew successfully. The average time interval between tumor implantation and measurable tumor growth for the five zenografts derived directly from patients was 36 days (range 25-40 days). The mean doubling time was 16 days (range 7-30 days). The overall take rate per animal for serial passage of tumor was 36 out of 43 (83.7%). The lag phase and the mean tumor doubling time decreased with each successive passage. At autopsy most tumors were confined to the subcutaneous structures by a well-formed capsule. Lymph node metastases and disseminated metastases were not seen. We conclude that the athymic mouse model is suitable to establish primary tumor growth of human laryngeal cancer.
Animals↗
High-dose methylprednisolone in the treatment of active ulcerative colitis.
Twenty patients with severe active ulcerative colitis were entered into a pilot study to test the efficacy of pulsed high-dose methylprednisolone in inducing remission. Of 20 patients, 12 improved, but 8 of 20 patients (40%) who did not went for urgent colectomy. The group proceeding to surgery tended to have more extensive disease. These results contrast unfavorably with historical control data from this unit.
Acute Disease↗
Making a rehabilitation hospital for the elderly work.
We report our efforts to make a rehabilitation hospital work. The simple intervention of introducing a patient record system, in which problems, management, achievements and discharge plans were clearly documented, doubled the number of patients who returned home over an eight-month period. This resulted in greater availability of acute geriatric beds at the District General Hospital (DGH), where two thirds of the elderly medical inpatients occupy beds on other units, and in an improvement in morale of patients and staff. Greater co-operation between geriatric and medical teams in selecting those patients who would benefit from continuing rehabilitation is required. The advantages of accommodating such patients separately from patients with a poor prognosis and those requiring long-term care are discussed.
Aged↗
Quantitative structural aspects of the renal glomeruli of hypertensive mice.
Kidneys of genetically hypertensive and normotensive mice were studied with respect to kidney weight, number and volume of glomeruli, and filtration surface area. The hypertensive animals have a larger kidney weight to body weight ratio and possess fewer glomeruli per kidney. The superficial cortical glomeruli of the hypertensives are slightly smaller in volume than those of the normotensives although the filtration surface area is similar. The juxtamedullary glomeruli of the hypertensives are both smaller in volume and have less filtration surface area. The possible implications of these findings in the development and/or maintenance of hypertension are discussed.
Animals↗
Non-Hodgkin's lymphoma after treatment for Hodgkin's disease.
A patient is described who developed a diffuse histiocytic lymphoma (DHL) 9 years after radiation therapy for Hodgkin's disease. This occurrence is of particular interest because the treatment for Hodgkin's disease included no chemotherapy and the second tumor appeared to originate remote from the irradiated site. Thus, the role of Hodgkin's disease treatment in the etiology of this patient's second lymphoma appears doubtful. The development of DHL in this patient could represent an unrelated event or conceivably an event facilitated by Hodgkin's disease itself.
Aged↗
A morphometric analysis of the glomerular capillary wall of a new strain of genetically hypertensive mice.
An investigation was performed on a new strain of genetically hypertensive mice to study those aspects of the renal glomerulus which have in the past been implicated in the etiology of renal parenchymal hypertension. Morphometric analyses were carried out utilizing a computerized graphic data analysing system on information obtained through transmission electron microscopy. Chronically hypertensive animals exhibited thinner basement membranes with numerous sub-epithelial focal thickenings, which were largely absent from the normotensive controls. No difference was noted in the width of the epithelial slit pores (interpedicelar spaces). The glomerular capillary loops of the hypertensive animals appeared otherwise unremarkable, as did the urinary space and parietal epithelium of Bowman's capsule. No evidence of renal parenchymal pathologies implicated in the etiology of systemic hypertension was observed, therefore, these animals would seem to be suitable models for human essential hypertension.
Animals↗
Letter: Nonspecific humoral response associated with secondary syphilis.
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Antibody Formation↗
Information technology enters the doctor's office: Part I--Six design and implementation lessons.
Because of a trend toward increased cost escalation outside of the hospital, in the ambulatory care setting, Metropolitan Life Insurance Company initiated an Ambulatory Utilization Review ("AUR") program in 1986. This is an overview of the lessons learned since that time. Some of what was learned was simply--or not so simply--"how to," the subject of this first article in a two-part series. Once this deceptively difficult technology was understood, there were two additional categories of lessons to learn: the extent of expected program results and some unexpected results. This second set of lessons is reviewed in Part II of the article.
Ambulatory Care↗
Investigation of colonic symptoms: the value of flexible sigmoidoscopy.
Colonic symptoms and large-bowel disease are common in elderly people, but the optimum investigative schema is not well established. Double-contrast barium enema (DCBE) and full colonoscopy share several drawbacks; both require colonic preparation which at best causes stool frequency and urgency, at worse dehydration and hypovolaemia. Many physicians feel that in the elderly this represents such a risk that inpatient preparation is preferred. Both investigations may involve much discomfort and distress. Rigid sigmoidoscopy is the traditional first colonic examination in patients with colonic symptoms, but will detect fewer than 10% of significant colonic lesions. Further investigation is almost always needed in elderly patients.
Adolescent↗