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Biomedical subjects

W Rosenbaum

Publications and source records attributed to W Rosenbaum.

12 recordsLinked to original sources
PubMed1992

[Non-typhic Salmonella bacteremias in HIV infections. Clinical and therapeutic data, and course in 68 patients].

Between 1982 and 1989, a retrospective study on non typhi Salmonella bacteremias was performed among patients infected with human immunodeficiency virus hospitalized in 4 departments of Infectious and Tropical Diseases in Paris. The population included 59 men and 9 women; 26.4 percent had been contamined with HIV by heterosexual contact; 17.6 percent originated from Africa or Haiti. Clinical symptoms were fever (100 percent of the cases), present since less than 5 days (65 percent of the cases), and gastrointestinal symptoms, present in 53 percent of the patients. Blood cultures were positive in all cases; Salmonella was less frequently found in other sites: stools (n = 13, 19 percent), urine (n = 5), lymph nodes (n = 1), sputum (n = 1). Mean CD4 cell count was 118 +/- 145/mm3. The serotypes were mainly S. typhimurium (n = 26), S. enteritidis (n = 23), and S. dublin (n = 15). Under antibiotic therapy, the course of the disease was initially favorable in 98.5 percent of the cases. One patient died of septic shock. At least one relapse occurred in 17 percent of the patients, 2.1 +/- 1.6 months after the end of the initial therapy. No relapse was observed in patients taking zidovudine or antibioprophylaxis, but 53 percent of the patients without antibioprophylaxis relapsed (P less than 0.001). The overall survival of the cohort was 25 percent after 18 months. These results show the poor prognosis of a first episode of Salmonella bacteremia in HIV infected patients, making the diagnosis of AIDS highly probable if cellular immunity is markedly impaired.

4-Quinolones↗
PubMed1992

[Accuracy of risk indicators of the Infant Life Defense Program in a region of the São Paulo State, Brazil].

The Infant Life Defense Program of Health Department of Bauru City SP, Brazil, has diagnostic criteria for the inclusion of newborns. The diagnostic criteria combine eleven social and clinical indices of infant mortality risk, defined by in the light of a review of the literature and previous case studies. The indices are easily collected at the hospitals during delivery. The objective of this study is to propose an alternative diagnostic criteria, using the same social and clinical indices, of greater sensitivity and same proportion of children included in the program. The data on the newborns were collected between May 11, 1986 and November 10, 1987. The mortality period was defined as between 7 days and 6 months, which was the follow-up period for the infants enrolled in the program. The method of analysis was the determination for each index of the crude relative risk in a univariate analysis and the adjusted relative risk using the logistic regression procedure. A score system was constructed on the basis of the sum of the excess risk of each index.

Brazil↗
PubMed1992

Bone manifestations associated with acquired immunodeficiency syndrome (AIDS).

To date, descriptions of bone manifestations associated with the acquired immunodeficiency syndrome (AIDS) have mostly been limited to case reports. Six such cases observed in our Departments of Rheumatology and Infectious Diseases, are reported. Three types of manifestations were observed: malignant lymphoma, infectious osteomyelitis, and reflex sympathetic dystrophy syndrome (algoneurodystrophy) secondary to central nervous system involvement.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Impaired in-vitro proliferation of hemopoietic precursors in HIV-1-infected subjects.

Patients with acquired immunodeficiency syndrome (AIDS) and persistent lymphadenopathy syndrome (LAS) display significant hematological abnormalities of one or more cell lineages. In order to understand the pathophysiologic mechanisms leading to these abnormalities we studied the proliferation capacity of pluripotent and committed hemopoietic precursors using in-vitro colony assays. Anemia, leukopenia and thrombopenia were relatively frequent findings in HIV-infected subjects irrespectively of the patients' clinical status. The colony growth capacity of AIDS patients' GM-CFU and BFU-E was significantly decreased whereas no GEMM-CFU colonies could be obtained. There was no correlation between the number of BFU-E and GM-CFU colony number and the hemoglobin or the absolute number of polynuclear cells, respectively. The plating efficiency of both committed and pluripotent hematopoietic precursors from HIV infected patients could not be enhanced when additional exogenous recombinant GM-CSF, human interleukin 3 or erythropoietin were added in contrast to normal patients' cells. In addition, the impaired colony growth of these precursors could not be restored after adherent or T-cell depletion or the addition of normal allogenic irradiated adherent or/and T cells. Since this colony growth abnormality was also detected in HIV seropositive asymptomatic subjects our findings strongly suggest that the in-vitro growth of hematopoietic precursors is affected early after HIV-1 infection.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Smoking and hospital utilization.

Remaining lifetime hospital days (RLHD) are used as estimates of possible differences in medical care costs between ever smokers and never smokers. Hospital usage by age in days per person per year comes from the 1970 U.S. National Health Interview Survey (NHIS) of some 40,000 households. Life table analysis for relative longevity of ever smokers and never smokers is based on mortality ratios presented in the American Cancer Society's Million Person Study. Results are similar to those obtained by Leu and Schaub for Swiss medical costs. There is no consistent increase in RLHD for ever smokers. In fact, male ever smokers older than 44 years and female ever smokers older than 38 years can expect fewer RLHDs than never smokers.

Adolescent↗
PubMed1984

[Beta 2 microglobulin in normal populations and populations at risk].

Quantitative analysis of beta-2-microglobulin (beta-2-M) may be a useful test for early diagnosis of acquired immuno-deficiency syndrome (AIDS). Even if beta-2-M is an unspecific marker, 96% of 45 patients with confirmed AIDS and 82% of 45 patients with lymphadenopathy have excessive (3 mg/l) beta-2-M value. beta-2-M is also useful in epidemiological studies, especially in subjects in close contact with patients, and in polytransfused hemophiliacs. At last, beta-2-M may be useful as a screening method in blood banks: from a study of 929 sera, excessive beta-2-M value was observed in 16 cases, which were excluded as blood donors.

Acquired Immunodeficiency Syndrome↗
PubMed1983

Random number generators for microcomputers.

The feasibility of random number generation using microcomputers is discussed and the appropriateness of alternative algorithms is evaluated on the basis of several criteria of statistical randomness. The relative deficiencies of each algorithm are cited and a modified Fibonacci generator is recommended for use in the microcomputer environment.

Computers↗