Biomedical subjects

W Rokicki

Publications and source records attributed to W Rokicki.

At least 19 recordsLinked to original sources

PubMed1990

Free cortisol of human plasma in the first three months of life.

Total cortisol as well as percentage and absolute free cortisol values were determined in 75 full-term, 88 premature and 38 small-for-age (born at term) infants in the first 3 months of life. Equilibrium dialysis and radioimmunoassay were used to estimate the percentage value of the unbound fraction and the value of total cortisol from which absolute free cortisol level was calculated, respectively. A systematic decrease in the free cortisol value was observed in all the three groups of infants during the study period (in full-term infants from 32.3 to 19%, in prematures from 36.6 to 20.8%, and in small-for-age infants from 32.3 to 19.2%). A comparison between the percentage values of free cortisol in the groups studied revealed only slight differences which were not significant. The absolute free cortisol values in full-term infants were highest immediately after birth (4.05 micrograms/dl), then they fell to the lowest level of 0.67 micrograms/dl observed between the third and fifth days of life, and increased afterwards reaching the level of 1.89 micrograms/dl in the third month. The absolute free cortisol values in premature newborns at 3-5 days of life exceeded the values observed in full-term subjects. The pattern of free cortisol in the prematures seems to be 'delayed' as compared with that in full-term newborns. The absolute free cortisol values in small-for-age infants were much more similar to those found in the full-term subjects, than to those in premature babies.

Female↗

PubMed1990

The effect of "end to side" portacaval anastomosis on regeneration ability of white rat liver.

The study evaluated the effect of portacaval anastomosis on the regeneration ability of the liver after partial hepatectomy in rat. The regeneration of liver was evaluated using the following tests: deoxyribonucleic acid synthesis, the activity of tyrosine aminotransferase (TAT) and the concentration of DNA and RNA in subcellular fractions of liver obtained by differential centrifugation. The results indicate the harmful effect of the portacaval shunting on the liver proliferation, which was near 50% decreased and the peak of the regeneration was delayed for about 12 hours. The most significant changes were observed in the nuclear and cytoplasmic fraction. In addition, high mortality ratio was found in the animals with portacaval anastomosis followed by partial hepatectomy.

Animals↗

PubMed1989

Congenital malformations and the environment.

The aim of the work was to search for the correlation between the environmental pollution and the ratio of congenital malformations found in the population of 54,493 newborn infants of three Silesian towns: Bielsko-Biała (situated in the mountains, close to a recreation part of the country), Bytom (situated in the center of an old industrial district, where industry is responsible for very high environmental pollution), and Tarnowskie Góry (situated close to vast woodlands, where very high environmental concentration of heavy metals is caused by an outdated, big zinc plant). In spite of big differences of environmental pollution indices between the three towns, the percentage of major congenital malformations diagnosed within the first three days of extrauterine life was almost identical (1.12% in Bielsko-Biała, 1.3% in Bytom, and 1.1% in Tarnowskie Góry).

Air Pollutants↗

PubMed1989

[Experimental studies of the pathomechanism of portal encephalopathy. I. Changes in monoamine oxidase (MAO) activity in the cerebral cortex and cerebellum of rats after portacaval shunt].

Rats with portacaval shunt (PCS) were used as a model of hepatic encephalopathy and compared to sham operated controls. Neurochemical studies in rats have demonstrated increased activity of MAO in brain cortex and cerebellum at 20, 40, and 60 days after surgery. The greatest increase of MAO activity was seen 60 days after PCS.

Animals↗

PubMed1989

[Neonatal blood aldosterone].

Postnatal aldosterone levels have been studied in 13 newborns from birth to the end of the 3rd day of life. The examinations were performed in children in whom blood samples were collected frequently for the clinical reasons (mostly because of suspected serologic incompatibility). Aldosterone level was measured by radioimmunoassay in the mixed cord blood and then at 2, 6, 12, 48, 72 hours after birth. Aldosterone concentration in the cord blood was 0.35 ng/dl and rapidly increased to 0.79 ng/dl during the first two hours after birth. The same value was obtained at the 6th hour of life. The mean aldosterone concentrations were 0.85 ng/dl at the 12th hour, 0.89 ng/dl at the 24th and 48th and 0.85 at the 72nd hour of life. Postnatal variation of aldosterone levels differs from previously investigated variations of glucocorticoids levels.

Aldosterone↗

PubMed1989

[Experimental studies of the pathomechanism of portal encephalopathy. II. Monoamine oxidase (MAO) activity in the rat brain after porta- caval shunt using 2 different methods].

The authors present effect of the end to side portacaval shunt (E-S PCS) and side to side portacaval shunt (S-S PCS) on monoamine oxidase (MAO) activity in brain cortex and cerebellum of rats. There were significant differences between two experimental models of PCS. Our results show greater increase in MAO activity after end to side portacaval shunt.

Animals↗

PubMed1988