Biomedical subjects
W Roeske
Publications and source records attributed to W Roeske.
In vitro osmoregulation of taurine in fetal mouse hearts.
Regulation of taurine transport and accumulation in explanted fetal mouse hearts is shown to be under osmotic control. All osmotic agents studied, both ionic (NaCl, LiCl, choline Cl) and nonionic (sucrose, glucose) stimulated [3H]-taurine transport during an incubation of 19 h. Hyperosmotic stimulation of transport achieved statistical significance by 3 h in the presence of sucrose (P less than 0.05). After 1 h, 40 mM NaCl engendered a 56% increase in [3H]-taurine transport (P less than 0.01). The NaCl stimulation at 1 h may relate more to the transport system's absolute sodium ion requirement than hyperosmotic stimulation. Incremental addition of NaCl or sucrose linearly stimulates [3H]-taurine transport in an incubation of 19 h. Total taurine, measured by HPLC, increased 25% with addition of either 40 mM NaCl or 80 mM sucrose. Hyperosmotic stimulation of transport was not blocked with propranolol but was additive to beta-adrenergic stimulation of transport. Osmotic stimulation occurred with a large increase in Vmax (0.41----0.81 nmol/mg tissue/h) but only a small change in Km (0.51----0.43 mM). After 1 h preincubation with a hyperosmotic addition phenylalanine transport was measured, but was not different from control. Phenylalanine accumulation measured during 19 h incubation similarly was not altered. Streptozotocin induced diabetic rats had elevated plasma osmolarities (295 +/- 2.1----322 +/- 1.3 mosmol) and cardiac taurine (24.3 +/- 1.2----36 +/- 1.0 mumol/g wet wt.). The data presented demonstrates that mammalian cardiac taurine is regulated by the osmotic environment of the heart, suggesting an osmoregulatory function for intracellular taurine and physiological relevance in disease states such as diabetes.
[Frescoes in old Polish pharmacies].
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[Museum of Pharmacy of the Medical Academy in Cracow].
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[Not Available].
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[Polish pharmaceutical weights and measures in the 19th century].
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[Alfons Bukowski (1858-1921)].
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["Miscellanea" from the history of German and Polish pharmacy].
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[Magna Charta Pharmaciae from 1240 and its influence on the development of mutual relationship between pharmacy and medicine].
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[Cosmas and Damian in the tradition of Polish medicine and pharmacy].
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Polish pharmacy in Copernicus' times.
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Musealia Pharmaceutica Polona in foreign collections.
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