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Biomedical subjects

W Ries

Publications and source records attributed to W Ries.

90 records · Page 5Linked to original sources
PubMedDate not supplied

[Motivations for determining biological aging].

Studies to determine the biological age of a person are a major concern of gerontological research today. The use of test batteries is now a proven method, and the procedure developed in Leipzig covers 47 parameters including physical, mental, and social data. It can be seen from the related findings that this approach is suitable for dealing with specific questions in gerontology. These include the detection of medical risk factors and environmental effects, and confirmation of intervention strategies. The prime motives behind these studies then seem to be in keeping with practical requirements.

Adult↗
PubMedDate not supplied

[Effect of obesity and food restriction on health and aging].

Based on experiences in animal studies, an attempt is made to illustrate all those mechanisms influencing the ageing process of human beings. The experimental part especially investigates the influence of food restriction in obese on the cardiovascular system and biological age. In middle-aged obese patients a normalization of initially altered noninvasive cardiodynamic parameters was achieved by isocaloric reduction diet. The biological age was influenced by food restriction too. If there is a correlation of overweight, food restriction and expectation live with human beings should be subject of further investigations.

Adult↗
PubMedDate not supplied

[Interpretation of a vitality model from the clinico-experimental viewpoint].

The vitality model conceived by Beier from a theoretical point of view is corroborated by clinical and experimental investigations of the authors. From a randomized study on the biological age of a statistically representative population group it can be concluded that the speed of ageing of this group is not linear in its course and hardly displays any differences between the sexes. Besides, distinct selection effects in advanced age suggest that the human population might consist of two sub-populations (the potentially long-lived and the potentially short-lived) who differ from one another with regard to the speed of ageing, morbidity and to the duration of life. Furthermore, similarities of the sex-specific change in vitality as occurs in the course of life, and the significance of this change for a possible reduction of male over-mortality are pointed out.

Adaptation, Physiological↗
PubMedDate not supplied

[12 years' analysis of serum fatty acids--final results of the Leipzig Longitudinal Gerontologic Study].

In the Leipzig longitudinal study performed from 1968 to 1980 in 383 test persons with healthy metabolism in 2-3 years time intervals gas-chromatographic analyses of the serum fatty acid pattern were carried out. In dependence upon age, sex, and body-weight the vasoprotective linoleic, linolenic and arachidonic acid increased and the vasoaggressive palmitic and eicosatrienic acid decreased. Influences of age as well as the change of the feeding habits are causally discussed for this purpose.

Adult↗
PubMedDate not supplied

[Sex differences in biologic aging. Results of an experimental study].

The authors report on first experimentally verified findings concerning the sex-specific ageing dynamism of man. The study is based on reference values of biological age which could be gathered by employing a clinical complex technique. This technique is conspicuous for its high precision; the reference-value quality of the model curves likewise satisfying all test theoretical criteria. The reference values of biological age characterize the dynamism of ageing within a randomized population group, i.e. 197 male and 168 female citizens aged between 18 and 75 years who were living in urban Leipzig and mainly employed in the working process. Remarkably enough, there hardly appear to be any differences between the two sexes as far as the rate of ageing is concerned. This causes the authors to emphasize the great importance of sex-differentiated morbidity for an increased mortality among men in the industrialized countries. A genetically predetermined higher rate of ageing among men and a resulting lower life expectancy exclusively contingent on it does not seem to exist. These experimentally obtained results correspond in tendency to epidemiological data.

Adult↗
PubMedDate not supplied

[Systolic time interval, stress ergometry and 133-xenon clearance in obesity].

Systolic time intervals were measured with 55 middle aged healthy normal weight and 76 healthy overweight probands in two positions (standing and lying). In 39 adipose patients and 55 normal weight subjects an ergometric work was carried out. A significant difference between normal and extremely adipose subjects without cardiac diseases could not be noticed with regard to the preejection index. Preejection period and left ventricular ejection time showed significant differences in both positions between normal and overweight probands, independent of blood pressure. In overweight patients there was a significantly decreased heart work load. The preejection index of adipose patients with a work load below 76 watts amounted to a mean value of 1,04. A work load of 100 watts was reached by only half of the adipose patients. In 32 adipose subjects with a heart work load above 75 watts the regulation of heart-rate and blood-pressure was not different from that of normal weight persons. Muscle blood flow was measured by 133Xenon-Clearance after Lassen et al. The measurement of the 133Xenon-Clearance of the arm muscle at rest in 29 adipose patients resulted in significantly lower values compared with normal weight persons.

Adult↗
PubMedDate not supplied

Selected metabolic results of the Leipzig gerontological longitudinal study.

The results of the longitudinal study show a gradual development of the overweight of young obese women. The decrease of weight in middle aged obese women is likely to be influenced by additional therapeutic measures by the physicians. It is interesting to note that men and women of normal weight do not develop overweight over a ten-years-span. Serum cholesterol increased in all age and weight groups within a ten-years-interval. The changes of the shares of total fatty acids were especially characterized by the decrease of palmitic acid and the increase of linoleic acid in the ten-years-interval. However age, weight and sex differences were present. The increase of uric acid level occurred with all test persons independent of sex. With test persons above 45 years a significant sex difference was noticed.

Adult↗
PubMedDate not supplied

[Biological age in patients with progressive scleroderma].

In 25 patients (10 male, 15 female) with systemic sclerosis aged between 28 and 79 years the biological age was determined. Alterations in the sense of "premature aging" were observed in the mean and developed stronger in male patients. They have to be counted in a greater part on the real process of disease. Compared to a healthy reference group, the expected diminishing of hand grip strength and tendon extensibility, vital capacity and partial oxygen pressure in the arteries could be confirmed. The latter correlated to an increase in rest pulse. Auditory acuity and the condition of the teeth were also reduced. Beyond that, noteworthy differences in psychological and social parameters not presumed at the beginning point to a decrease in social activities and to psychic changes. They underline the necessity of psychological counseling of the patients.

Activities of Daily Living↗