The present study determines the analgesic effects of morphine in grouped and isolated rats and mice. Isolated animals developed altered behavioral patterns, including mouse-killing in rats and mutual aggressiveness in mice. The analgesic effect of morphine was tested by tail compression in rats and by the hot plate for mice. Isolated rats developing mouse-killing behavior had a raised pain threshold, while indifferent animals (nonkillers) responded less to morphine. Isolated mice, particularly low aggressors, gave enhanced responses to morphine.

Aggression↗

PubMed1976

[50th anniversary of Prof. Piotr Kubikowski's scientific activity].

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History of Medicine↗

PubMedDate not supplied

The analgesic action of some flavonoids in the hot plate test.

Albino-Swiss male mice were tested in the hot plate test. Oligomeric procyjanidin (OL-1), rutin, quercetin, hyperoside and vitexin rhamnoside were administered intraperitoneally in doses 3.5 and 10 mg/kg. It was found that OL-1, rutin and hyperoside but not vitexin rhamnoside exert analgesic action, whereas quercetin even decreases the pain threshold level. The mechanism of the analgesic action of flavonoids remains to be explained.

Analgesia↗

PubMedDate not supplied

[Clinical pharmacology of amiodarone].

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Amiodarone↗

PubMedDate not supplied

[Metabolism of morphine, its analgesic activity and adverse reactions during prolonged administration by various routes].

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Drug Administration Schedule↗

PubMedDate not supplied

[Significance of stereoisomer drugs in therapy].

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Animals↗

PubMedDate not supplied

[Effect of liver diseases on pharmacokinetics of drugs].

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Biological Availability↗

PubMedDate not supplied

Effects of some neuroleptic drugs on aggressive behavior in isolated mice.

Effects of some neuroleptic drugs on aggressive behavior in isolated mice. Acta Physiol. Pol. 1979, 30 (2): 295--298. Albino-Swiss male mice were isolated for 28 days and their isolation-induced aggressive behavior was tested after housing them in groups. The effects of the following neuroleptics were investigated: spiroperidol (0.2 mg/kg i.p.), pimozide (1 and 2 mg/kg i.p.), and clozapine (2 and 5 mg/kg i.p.). Among the drugs examined the strongest inhibitory action on the isolation-induced aggressive behavior was inserted by spiroperidol. Primozide and closapine had weaker, but significant anti-aggressive effect.

Aggression↗