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Biomedical subjects

W Remmele

Publications and source records attributed to W Remmele.

At least 37 records · Page 2Linked to original sources
PubMed1988

Karl Touton and his "xanthelasmatic giant cell." A selective review of multinucleated giant cells.

The position of the Touton giant cell in relation to the foreign body and Langhans type of giant cell is considered. (A short account of Karl Touton's life is also included.) After reviewing the historical development of the concept of giant cells and current interpretations of their nature, the unitarian view of polykaryons now favored by workers in the field is extended to include also the "xanthelasmatic giant cell" of Touton, whose characteristic appearance is determined merely by the presence of demonstrable lipid in the cytoplasm. It is proposed that Touton cells develop when the stimulus to cell fusion is accompanied also by a factor stimulating lipid uptake. This factor is missing in the development of the other two giant cell "types," but apart from that there are no other significant differences.

Cytoplasm↗
PubMed1986

Comparative histological, histochemical, immunohistochemical and biochemical studies on oestrogen receptors, lectin receptors, and Barr bodies in human breast cancer.

The present study performed on a total of 567 cases of human female breast cancer compares the results of the biochemical assay (dextran-coated charcoal assay = DCC) for oestrogen receptor (ER) with those of several morphological methods developed for the detection of the ER or for the prediction of prognosis by use of other systems (FSA = fluorescent ligand binding assay, ER-ICA = monoclonal antibody assay for ER, LRA = lectin receptor assay using peanut agglutinin, and Barr body estimation). Whereas no correlation at all was observed among the results of the DCC and those of the FSA and Barr body estimation, the ER-ICA and the LRA showed an unanimous tendency towards higher values of ER with increasing intensity of the staining product. The results of the ER-ICA may be expressed by an immuno-reactive score (IRS) calculated from the staining intensity (SI) and the percentage of positive cells (PP). The morphological methods are evaluated with special regard to their correlation with the DCC, their theoretical basis, and their practical application. In summary, the ER-ICA appears to be the sole method directly visualizing the ER protein and--in contrast to the DCC--is therefore completely independent of the content of endogenous or exogenous oestrogens in the tumor tissue. The LRA provides valuable additional information concerning tumour differentiation and possible response to endocrine therapy, whereas the FSA and Barr body estimation should be considered as obsolete and should therefore be abandoned.

Antibodies, Monoclonal↗
PubMed1986

Anorectal ergotism: another cause of solitary rectal ulcers.

Anorectal ulceration was observed in 6 patients who excessively used suppositories containing ergotamine tartrate. The mucosal lesions of the rectum resembled those observed in the "solitary rectal ulcer syndrome." However, characteristic features of ergotamine-induced ulcers are absence of a mucosal prolapse, lack of a history of constipation, and rapid healing after discontinuation of the drug. Furthermore, the rectal lesion may be associated with anal ulceration, which occasionally presents as the only clinical manifestation of "anorectal ergotism."

Adult↗
PubMed1984

Eighty months persistence of poorly differentiated early gastric cancer.

A patient is presented who was diagnosed in 1976 as having a signet-ring cell carcinoma of the gastric antrum. The patient delayed surgery for 7 yr, after which time an early gastric cancer of the intramucosal type was found. It is suggested that in addition to its high cure rate, early gastric cancer may have an extraordinarily slow growth.

Adenocarcinoma, Mucinous↗
PubMed1978

Malignant transformation of hyperplasiogenic polyps of the stomach--case report.

Case report of a 71 years old female with multiple hyperplasiogenic gastric polyps with malignant transformation of two polyps. So far, the hyperplasiogenic polyp was considered to be only an "indicator lesion" because the incidence of gastric cancer (apart from the polyps themselves) was found to be increased in these patients. This opinion has to be revised in view of the present case. The consequences for diagnosis, treatment and nosologic classification of hyperplasiogenic gastric polyps are discussed.

Aged↗
PubMed1978

[Gastric xanthelasma (author's transl)].

A report is given about 42 cases with xanthelasma of the gastric mucosa diagnosed with 5 1/2 years. The condition was found (considering the total number of gastroscopies) in men 1.38 times as often as in women; the average age of all patients at the time of diagnosis was 62.5 years. Xanthelasma lesions are yellow or yellowish-white spots in the mucosa, consisting of foam-cells microscopically. The cytoplasma stains pale pink in a HE preparation; there is almost no staining with PAS, and sudan black staining is definitely positive in most cases. PAS and sudan black staining do allow differentiation of signet ring carcinoma cells. Gastric xanthelasma occurs quite often concurrently with chronic gastritis. It is due to local, not to general disturbances of lipid metabolism. Lipids probably are formed within the mucosa cells or may--in cases of intestinal metaplasia--originate from the gastric contents. Gastric xanthelasma does not constitute a nosologic entity, it is merely a consequence of other diseases of the gastric mucosa.

Adult↗
PubMed1978

[Colorectal polyps. Pathologico-anatomical and statistical studies on 3037 polyps].

Report on 3037 colorectal polyps from the Deutsche Klinik für Diagnostik Wiesbaden that were observed within about 6 years and submitted to microscopic examination. The polyps were classified according to the WHO nomenclature, 1976. Adenomas and metaplastic (hyperplastic) polyps were the most frequenty types. The terms 'carcinoma in situ,' 'focal carcinoma,' 'adenoma with severe cellular atypia,' and 'malignant polyp' are explained and discussed in view of possible false interpretations by the surgeon. It is stressed that only the term 'adenoma with severe cellular atypia' (WHO classification) should be retained. In 286 cases, primary multiplicity of polyps was observed. There were recurrent polyp(s) in 154 cases (7%). Most frequently the recurrent polyp(s) corresponded to the type that had been found during the first examination. Finally, some remarks are made concerning the techniques of biopsy and of pathological examination.

Adenoma↗
PubMed1977

[Colonic histiocytosis (author's transl)].

Macrophages accumulating various substances can be detected in the mucosa of the small and large bowel under physiological and various pathological conditions. Among these the so-called PAS-positive macrophages have attracted much attention in recent times. Abundant occurrence of such cells in the intestinal mucosa has been termed "colonic histiocytosis". The occurrence of PAS-positive macrophages was investigated in 200 unselected and otherwise normal biopsy specimens of rectal mucosa; no correlation was found between the occurrence of these cells on the one hand and any intestinal or extraintestinal disease on the other. PAS-positive macrophages were mostly found close to the surface of the mucosa or to the cryptal epithelium as well as between the crypts. It is suggested to abandon the term "colonic histiocytosis" since it induces a false impression of a disease entity in the clinician (and may be related falsely e.g. to "histiocytosis X", and since the clinician may tend to attribute unnecessary importance to this harmless finding.

Adult↗
PubMed1976

Bone formation by cancer metastases: case report and review of literature.

The formation of heterotopic bone tissue in malignant tumors or in their metastases is extremely rare. In a 60 years old male patient with bronchogenic carcinoma (adenocarcinoma) extensive bone formation was observed within multiple metastases in the skeletal muscles. On the basis of the microscopic findings, the mechanism of bone formation by malignant tumors is discussed. Obviously, proliferation of local mesenchymal tissue and differentiation of mesenchymal cells to osteoblasts is induced by the tumor cells.

Adenocarcinoma↗