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Biomedical subjects

W Reiterer

Publications and source records attributed to W Reiterer.

At least 19 recordsLinked to original sources
PubMed1991

Effect of isradipine and atenolol on lung function in patients with mild essential hypertension.

Twenty-six hypertensive patients took part in an open, randomized, parallel-group pilot study of the effects of a nine-week treatment period with the calcium antagonist isradipine and the beta 1-blocking agent atenolol. The mean dosage in the isradipine group was 7.9 +/- 3.5 mg/day, and 69.2 +/- 43.5 mg/day in the atenolol group. A significant reduction of the arterial blood pressure was seen with both treatment regimens. Lung volumes and airways resistance remained unchanged, but, in the atenolol-treated group, the linear relationship between alveolar pressure and airways resistance at the lower lung volumes during forced expiration at 25% of forced vital capacity was affected by a shift to higher airways resistance. This change can be interpreted as an early sign of altered air-flow behavior in the small airways in subjects susceptible to beta-adrenoceptor blockade. The calcium antagonist isradipine did not produce changes in any parameters of lung function in this group of patients.

Adult↗
PubMed1989

[Exercise capacity of coronary heart disease patients in long-term follow-up with gallopamil in comparison with premedication with verapamil].

In 15 patients with coronary heart disease (mean data: age 60.4 years, body-weight average 72.5 kg, four females, eleven males, six patients with myocardial infarction) the long-term treatment with verapamil (340 mg/die p.o.) was replaced by gallopamil (123 mg/die). In six patients the additional treatment with long-lasting nitrates was continued. During a period of 1 year symptom-limited exercise tests (bicycle ergometry) were performed repeatedly (baseline, 1, 3, 6, and 12 months later). In comparison to the pretreatment with verapamil the calcium channel blocker gallopamil proved to be equally effective on the overall exercise performance, heart rate, and blood pressure regulation. Parameters of myocardial ischemia (maximal ST-depression, onset of significant ST-depression, duration of ST-changes after cessation of work) are less evident. Minor side effects include prolongation of the PQ-interval (0.24 on the mean in five patients) and arterial hypotension (two patients). One patient underwent coronary artery surgery as the complaints of angina pectoris worsened.

Aged↗
PubMed1986

[Use of a personal computer system at a cardio-pulmonary function laboratory for text processing, graphics and statistics].

To improve the off-line data processing a personal-computer-system was set up, including a HP-85A desk-computer with a dual-disc-drive, a plotter, a printer and a digitizer (graphical tablet). The application of the personal-computer-system is focused on the work up of medical reports and records, transformation of physiologic data into graphics (ergometric stress testing, myocardial function curve, lung mechanics) and on speeding up the flow and distribution of information. Further applications include a literature storage and retrieving system, the quantitative analysis of left ventricular wall motion by two dimensional echocardiography and a graphic aided system for medical statistics. Hopefully the data processing at a cardio-pulmonary function laboratory will lead to a better definition of diseased states in quantitative terms and by this support the rational basis for medical intervention. Slow communication of medical information is a critical factor in the practice of high quality medical care (cost/efficiency).

Computer Graphics↗
PubMed1983

Acute effects of alinidine on heart rate and blood pressure in healthy subjects and patients with hyperkinetic heart syndrome.

The effects of a single dose of alinidine (0.5 mg/kg i.v.), the N-allyl-derivative of clonidine, on heart rate and blood pressure were investigated in healthy volunteers and in patients with hyperkinetic heart syndrome, at rest and during bicycle exercise. In healthy volunteers plasma catecholamine levels were also determined. Alinidine did not change heart rate at rest in the healthy volunteers but it did significantly reduce exercise-induced tachycardia, whereas blood pressure and plasma catecholamine levels were not significantly affected by alinidine, either at rest or during exercise. In patients with hyperkinetic heart syndrome, alinidine reduced heart rate at rest and during exercise to a similar extent as propranolol (0.1 mg/kg i.v.). The blood pressure did not change with alinidine but it was significantly reduced by propranolol. The observation that an alinidine-induced reduction of heart rate occurs without a concomitant fall in blood pressure, and without a clonidine-like symphatho-inhibitory action, is in line with experimental findings suggesting a specific bradycardic action of alinidine under short-term conditions.

Blood Pressure↗
PubMed1980

[Effects of nitroglycerin on exercise hemodynamics in patients with coronary heart disease under treatment with beta-blockers (mepindolol, oxprenolol) and a calcium-antagonist (fendiline) (author's transl)].

Nitroglycerin (0.8 mg p. o.) improves exercise hemodynamics in patients with coronary heart disease by normalizing left ventricular filling pressure and elevating volume output. Exercise heart rate and mean arterial blood pressure remain unchanged. Pretreatment with a beta-receptor-blocker (Mepindolol) and the combination of beta-receptor-blocker (Oxprenolol) with a calcium-antagonist (Fendiline) reduces the efficacy of nitroglycerin. The effects of the underlying treatment on the ventricular function curve shifting rightwards are not antagonized by nitroglycerin.

Adrenergic beta-Antagonists↗
PubMed1980

Effects of different preparations of oxprenolol on diurnal variations of non-steady-state exercise performance in patients with coronary heart disease evaluated by computer assisted ergospirometry.

The effect of two preparations of oxprenolol (80 mg twice a day; 160 mg slow-release once a day) on the diurnal non-steady-state exercise performance in patients with coronary heart disease (N = 11) has been studied after a treatment period of at least 7 days. 2 h after the intake of the standard preparation (80 mg oxprenolol) the symptom-limited exercise performance increased by 24%. The onset of symptoms of physical intolerance was postponed to work rates of heavier intensity (+18.8%). Despite a considerable fall in the exercise heart rate (-18.4%) the oxygen uptake per load was not affected suggesting that the adjustment of the cardio-pulmonary system to graded exercise was not impaired. As the reduction of the exercise heart rate is regarded as a distinct sign of beta-receptor blockade the standard regimen demonstrates a considerable long-term effect with respect to the heart rate regulation next morning (time interval 16 h). The slow-release preparation acts less powerfully in reducing the exercise heart rate in any test, but the beneficial effects on limiting symptoms of physical performance equal the standard regimen. The duration of the efficacy of slow-release oxprenolol is certainly limited: no effect on the exercise heart rate was demonstrable next morning (time interval 25 h). To improve the efficacy in symptomatic treatment of coronary heart disease the duration of effects of the drug and the physical activities of the individual during every day life should be taken into account to adjust the timing for intake.

Adult↗
PubMed1977

[Physical performance in patients with focal infection ergospirometric stress-testing before and after tonsillectomy (author's transl)].

The diagnosis of a focal infection in 13 patients (6 men and 7 women, aged 18 to 36) was based on the findings of chronic tonsillitis and general complaints interpreted as focal symptoms. The patients underwent symptom-limited maximal stress-testing before and after tonsillectomy to rule out any impairment of physical performance on the basis of computer-assisted processing of ergospirometric data. It can be concluded that the actual data of maximal oxygen uptake (aerobic power), the phenomenon of adaptation to increasing work loads (derived from rating of the increase in oxygen uptake during rectangular-triangular bicycle ergometry), the on-line processed index of anaerobic power and the anaerobic threshold, as well as heart rate and arterial blood pressure regulation did not differ in these patients from findings in healthy subjects. Nor were these parameters altered by tonsillectomy. Tonsillar focal infection is unlikely to cause any impairment of physical performance with respect to parameters of cardio-respiratory and metabolic function.

Adaptation, Physiological↗
PubMed1976

[On-line analysis of anaerobic power and oxygen debt in rectangular-triangular stress testing (author's transl)].

The rectangular-triangular bicycle exercise test with on-line analysis of respiratory function and gas exchange is used in the evaluation of physical performance. A programme has been developed for on-line computation of an index of anaerobic power and of oxygen debt. The index of anaerobic power is calculated by subtracting the oxygen uptake exceeding the resting values from the energy demand to sustain a given work load. The oxygen uptake exceeding the resting level during a period of five minutes after the exercise test is added up and the result is taken to represent the index of the oxygen debt. In this presentation of preliminary results it is concluded that the index of anaerobic power and the parameter of anaerobic power (maximal oxygen uptake in symptom-limited stress testing) provide valuable additional information in regard to the physical performance of untrained people, athletes and patients with impaired cardio-pulmonary function in quantitative terms.

Adult↗